Many gut-derived peptides have been considered as candidates for novel therapeutics for obesity and/or T2DM. However, so far, only a few have progressed to specific clinical trials.

Endogenous GLP-1 is rapidly processed by DPP4 in the gastrointestinal tract, resulting in very low blood levels of the active form GLP-1. This raises the question of how gut-derived GLP-1 can activate enough GLP-1 receptors in distant tissues to achieve its physiological function., 2011; Mulvihill et al. Encodes the GLP-1 prohormone, preproglucagon, which is also present in extraintestinal tissues.

This article aims to discuss the variety of methods currently being developed that seek to take advantage of the gut as a new therapeutic approach with the hope that we can achieve the effectiveness of these therapies. surgical intervention with less invasive and more scalable solutions in the treatment of metabolic diseases.

Diabetes (also known as diabetes mellitus) is tending to be younger and has unpredictable developments. When feeling nauseous, thirsty, numb limbs, slow-healing wounds,... young people need to proactively go to a medical facility for examination, because these could be signs of diabetes.

When you have diabetes, you will have symptoms of blurred vision and reduced vision. The reason is that high blood sugar causes the lens of the eye to swell, changing your ability to see.

When you have diabetes, your body cannot move sugar from your blood into your cells, leading to high blood sugar levels. Glucose, the form of sugar normally found in your blood, is one of your body's main sources of energy. A lack of insulin or insulin resistance causes sugar to build up in your blood, leading to a number of health problems.