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Panactol contains the ingredient Paracetamol, which is effective in the treatment of pain and fever. The drug is also indicated in women with menstrual pain, pain after tooth extraction or other dental procedures.1. What is Panactol?
Panactol drugs include the following types:
Panactol325mg ; Panactol 500mg; Panactol 650mg. Paracetamol is an effective pain reliever and fever reducer. Panactol will act on the thermoregulatory center in the hypothalamus to cause hypothermia, and at the same time increase thermogenesis due to vasodilation and peripheral blood flow, reducing the body temperature of patients with fever. However, Panactol is also rarely able to lower a normal body temperature.
Panactol drug is taken orally, the Paracetamol component is able to be quickly and completely absorbed in the body. Paracetamol concentrations peak in plasma about 10 to 60 minutes after dosing.
Panactol into the body will be distributed quickly and evenly in most tissues of the body, about 25% of Paracetamol in the blood will be combined with plasma proteins. Paracetamol compounds are metabolized mainly in the liver by two pathways. However, the major route of metabolism in the liver is conjugation with glucuronic acid along with sulfuric acid. Paracetamol metabolites are mainly eliminated from the body through urine. In adults, approximately 90% of the administered dose is eliminated from the metabolite within 24 hours. The metabolites are eliminated mainly in the form of glucuronide conjugates accounting for 60% and sulfate conjugates accounting for 30%. 5% of the substance is eliminated unchanged, the plasma half-life is about 2 hours.
2. Indications and contraindications for the use of Panactol
Panactol is indicated for use in the treatment of pain, mild to moderate fever, colds, flu, headache, musculoskeletal pain, sprains, joint pain, back pain, toothache , menstrual pain , traumatic pain , neuralgia , earache , sore throat , pain due to dental related surgery such as tooth extraction or ENT related surgery such as tonsillectomy .However, Panactol is contraindicated in some cases with hypersensitivity reactions to the components of the drug. Or cases of glucose 6-phosphate dehydrogenase deficiency, people with advanced liver disease or severe liver failure.
3. Dosage and how to use Panactol
3.1. Dosage of Panactol For normal adults with fever or aches, the dose of Panactol is about 325mg to 650mg, each dose is 4 to 6 hours apart or can be used in a dose of 1000mg, each dose is spaced. from 6 to 8 o'clock.
For children, the usual dose for fever or pain is:
Under 1 month of age, children should be given a dose of 10 to 15 mg/kg/dose. Each dose is spaced 6 to 8 hours apart; Children from 1 month to 12 years of age should receive a dose of 10 to 15 mg/kg/dose. Each dose is spaced 4 to 6 hours apart; Children over 12 years of age should take 325mg to 650mg, each dose is 4 to 6 hours apart, or 1000mg can be used, each dose is 6 to 8 hours apart. The above drug dosage is for reference only. Therefore, if you use the drug to improve the health of your eyes, it is necessary to carefully study and consult an ophthalmologist.
3.2. How to use Panactol Panactol is taken by mouth with or without food.
If you forget a dose, you should take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take it as planned. Do not use a double dose.
In case of overdose of Panactol, symptoms such as nausea, vomiting, abdominal pain, cyanosis of the skin and mucous membranes, ... these manifestations can occur within 2 to 3 hours. after taking an overdose. Overdose in children can cause hepatocellular destruction or even irreversible necrosis. In case of serious overdose, emergency treatment in the hospital is necessary by washing the intestines, giving activated charcoal or using N-acetylcysteine, supporting airway therapy.
4. Some notes when using Panactol
Using Panactol can cause side effects in some cases. Common side effects include skin rash or other allergic reactions such as urticaria, erythema and possibly fever. Persons sensitive to salicylic acid are rarely hypersensitive to paracetamol or related drugs. With some special cases can cause neutropenia, thrombocytopenia or pancytopenia.
Some rare side effects related to skin rash or stomach irritation, blood dyscrasias, anemia, kidney disease when abused and used for a long time.
Interaction of the drug Panactol when using high doses and long-term anticoagulant effects of coumarin and indandion derivatives. If Panactol is combined with anticonvulsants, isoniazid increases the toxicity of Paracetamol. Drugs used in patients with long-term alcohol consumption may increase hepatotoxicity.
Therefore, when using Panactol, the following should be noted:
Patients should be cautious in patients with pre-existing symptoms of anemia or impaired liver and kidney function. If taking Panactol overdosage or long-term treatment can cause liver necrosis and kidney failure. In addition, with Panactol, doctors should warn patients about signs of serious skin reactions such as Steven-Johnson syndrome (SJS), Lyell, acute generalized pustular rash or skin necrosis. poisoned. Panactol can cause dizziness and drowsiness, so people who drive and operate machinery should be careful when using it. For women who are pregnant and breastfeeding, caution should be exercised when using Panactol and should only be used under the direction of a physician. Through this article, you probably know what Panactol or Panactol 500mg is. The use of Panactol can cause side effects such as nausea, abdominal pain... Therefore, you need to learn carefully and consult a doctor before using.
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