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Infectious diseases that require treatment with appropriate antibiotics. One of the commonly used antibiotics is Fabafixim 200 or 400. So what does Fabafixim 400 do?
1. What is Fabafixim 200, 400 mg?
Fabafixim 200 or 400 mg is a drug manufactured by Central Pharmaceutical Joint Stock Company I. The drug has the main ingredient is cefixime - a 3rd generation Cephalosporin antibiotic, has bactericidal effect by attaching to The target protein inhibits the synthesis of mucopeptides in the bacterial cell wall. Cefixime is used to treat upper respiratory tract infections, lower respiratory tract infections, and urinary tract infections caused by strains of bacteria that are still susceptible to this antibiotic. Fabafixim 200 or 400 mg with cefixime content of 200mg and 400mg respectively is prepared as dispersible tablets.
The clinical efficacy of cefixime has been demonstrated in infections caused by common bacteria such as: Streptococcus pneumoniae, Streptococcus pyogenes, Escherichia coli, Proteus mirabilis, Klebsiella, Haemophilus influenzae (secreting and non-secreting beta-lactamases). ), Branhamella catarrhalis (secreting and not secreting beta - lactamase) and Enterobacter species. Drugs containing cefixime have high stability in the presence of beta - lactamase enzymes.
Note, most intestinal bacteria strains such as streptococcus faecalis, group D streptococcus... and staphylococcus including coagulase-secreting and non-producing strains, methicillin-resistant strains... are already resistant to antibiotics cefixime . In addition, strains of Pseudomonas, Bacteroides fragilis, Listeria monocytogenes and Clostridia are also thought to be resistant to cefixime antibiotics.
2. What are the effects of Fabafixim 400?
Indications of Fabafixim 200 or 400 mg include:
Treatment of upper respiratory tract infections: Otitis media and other upper respiratory tract infections where pathogenic bacteria have been identified or suspected to be capable of are already resistant to other commonly used antibiotics, or are indicated when there is a significant risk of failure of other antibiotics; Treatment of lower respiratory tract infections: bronchitis; Treatment of urinary tract infections: cystitis, cholecystitis, uncomplicated cholecystitis.
Thuốc Fabafixim 200 và 400 có tác dụng điều trị các bệnh nhiễm khuẩn
3. Dosage of Fabafixim 200 or 400 mg
Fabafixim 200 or 400 mg are taken orally. Mix Fabafixim tablets in about 50 ml of water, then stir well and drink, need more water to rinse the medicine in the cup and drink the water to rinse the cup to ensure the full dose, note that the absorption of the drug does not change significantly. in the presence of food. A course of antibiotic treatment is usually 7 days or can be continued until 14 days as needed as directed by the doctor.
Dosage of Fabafixim for adults, elderly people and children over 10 years old or people weighing more than 50 kg: 1-2 tablets of Fabafixim 200 (or 1 tablet of Fabafixim 400) daily depending on the severity of the infection. , can be used once or divided into 2 times. For children under 10 years old should use the form of powder mixed oral suspension. Dosage for patients with renal impairment: Creatinine clearance > 20 ml/min does not require dose adjustment Fabafixime 200, creatinine clearance < 20 ml/min or patients on hemodialysis and chronic peritoneal dialysis should not exceeding the dose of 200 mg x 1 time / day (ie 1 tablet of Fabafixim 200 ). The dosage of Fabafixim 200 or 400 above is for reference only, the specific dosage of each patient depends on the condition, severity of the disease and the doctor's instructions.
4. Fabafixim side effects
Common side effects (ADR > 1/100):
Gastrointestinal disturbances such as diarrhea, broken stools, abdominal pain, nausea, vomiting, flatulence, dry mouth or loss of appetite. Gastrointestinal disorders mostly occurred in the first 1-2 days of taking Fabafixim 200 and responded well to measures to manage symptoms, rarely requiring discontinuation of the drug; Nervous system disorders such as headache, dizziness, restlessness, insomnia, fatigue; Hypersensitivity conditions such as erythema, urticaria, drug fever. Uncommon side effects (1/1000 < ADR < 1/100)
Gastrointestinal disturbances such as severe diarrhea due to Clostridia Des difficile and pseudomembranous colitis; Anaphylaxis, angioedema, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis; Hematologic disorders such as thrombocytopenia, transient eosinophilia, decreased hemoglobin concentration; Liver dysfunction such as hepatitis, jaundice, transient elevation of liver enzymes, elevation of alkaline phosphatase, bilirubin and LDH; Renal dysfunction such as acute renal failure, transient increase in plasma creatinine concentration; Vaginal Candida infection. Some rare side effects of Fabafixim 200 (ADR < 1/1000):
Prothrombin time prolongation; Convulsions.
Fabafixim 200 có thể gây rối loạn tiêu hóa ở một số ít người dùng
5. Note when using Fabafixim 200
Contraindications: Fabafixim 200 is contraindicated for cases of allergy to cefixime, other cephalosporin antibiotics or history of penicillin-induced anaphylaxis; There have been cases of serious skin adverse reactions such as skin necrosis, Stevens-Johnson syndrome, drug-induced skin rash with eosinophils and systemic symptoms (DRESS) with the use of the drug. Fabafixim 200 ; Cases of hemolytic anemia when using Cephalosporin antibiotics, which can be fatal; Fabafixim 200 ingredients contain aspartame (4mg each) so caution should be exercised in people with phenylketonuria; Before starting to use Fabafixim 200, doctors need to carefully explore the patient's allergy history, especially to penicillin antibiotics, other cephalosporins; Fabafixim 200 should be used with caution in people with a history of gastrointestinal disease and colitis (with prolonged use) because of the risk of developing resistant strains of bacteria, especially Clostridia Des difficile; The dose and/or frequency of administration of Fabafixime 200 in patients with renal impairment (including on hemodialysis) requires adjustment due to higher plasma concentrations and longer elimination times compared with functional subjects. normal kidney function; Data on the safety and efficacy of Fabafixim 200 in children under 6 months of age are unclear; In general, there is no need to adjust the dose of Fabafixim 200 when used in the elderly, except in cases of impaired renal function; Pregnant women: There are no adequate research data on the use of Fabafixim 200, so only use when absolutely necessary; Lactation: It is not known whether Fabafixim 200 is excreted in human milk. Therefore, caution should be exercised when using Fabafixim 200 for subjects, and at the same time, it is possible to temporarily stop breastfeeding while taking the drug.
6. Fabafixim 200 . Drug Interactions
Probenecid increases the peak concentration and AUC of the antibiotic cefixime, and also reduces the renal clearance and volume of distribution of the drug; Anticoagulants such as warfarin when used in combination with Fabafixim 200 may increase prothrombin time, with or without bleeding; Carbamazepine in combination with Fabafixim 200 may increase the plasma concentration of carbamazepine; Nifedipine in combination with the antibiotic cefixime may increase the bioavailability of cefixime through an increase in peak concentrations and AUC. Fabafixim 200 or 400 mg is an antibiotic indicated for the treatment of infectious diseases. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to take medicine according to prescription or consult a doctor, professional pharmacist.
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