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To support the treatment of hepatobiliary diseases or in combination when treating hepatotoxic drugs, which will help protect liver cells, arbitol 400 is a good choice for many patients. So what is arbitol? Read more articles below to help you understand more about arbitol 400.
Learn about the drug arbitol 400
1.1. What is arbitol? Arbitol 400mg capsule has the main ingredient is Arginin hydrochloride, belongs to the group of prescription drugs ETC - (Ethical drugs, prescription drugs, Prescription only medicine) has the main effect in supporting the treatment of liver dysfunction.
Arginine is a diamino monocarboxylic amino acid. It is classified as a nonessential amino acid. However in certain situations such as sepsis, stress, trauma, it can become semi-essential or conditionally necessary. Arginine is a precursor for protein, nitric oxide, creatine, and polyamine synthesis, and an intermediate in ammonia detoxification via the ornithine cycle. Arginine has been linked to boosting immunity, releasing human growth hormone, increasing muscle mass, speeding wound healing, increasing sex drive, and helping to reverse atherosclerosis. In adults, the endogenous synthesis capacity for arginine, which accounts for about 20% of the daily requirement, is relatively small compared with the daily requirement. Therefore, a dietary arginine supplement becomes indispensable under conditions of increased demand such as growth, and tissue repair or decreased dietary supply. Arginine has been reported to have immunosuppressive effects, especially under catabolic conditions. Additionally, it helps detoxify the liver by neutralizing ammonia, and may be beneficial in treating liver disorders such as cirrhosis and fatty liver.
1.2. Mechanism of Action Arginine The action of arginine is to stimulate the release of growth hormone, glucagon, insulin, and prolactin, independent of the control of changes in blood glucose levels and adrenaline release. Some studies suggest that it may be due to the effect on the hypothalamus that Arginin stimulates the release of growth hormone and prolactin from the pituitary gland.
In patients with a normal pituitary gland, after taking Arginine for a while, blood tests showed increased plasma growth hormone levels. In patients with impaired pituitary function, the blood levels of growth hormone do not increase or increase very little.
Arginin is considered an essential amino acid in the ornithine cycle (a biochemical reaction that produces urea ((NH2)2CO) from ammonia (NH3). The ornithine cycle produces intermediates that are less toxic and readily available compared with ammonia. It is more excreted in the urine, establishing another pathway for the elimination of excess nitrogen.
Arginin increases blood glucose levels This effect can be considered as a direct effect; when glucose is released from the liver is directly related to the amount of amino acids absorbed.Glycogen interpretation and new glucose regeneration can also be mediated by the process of arginine stimulating glucagon release. liver toxicity, neutralize excess ammonia in the body and contribute to the treatment of hepatitis, cirrhosis, Detoxifies the liver, lowers cholesterol in the blood, helps you eat better, fights obesity, and does not darken skin. The combination of Arginine and Glutamine provides more energy to the body by detoxifying the muscles.
Arbitol được ứng dụng trong hỗ trợ điều trị các bệnh lý gan mật
2. The uses of the drug Arbitol 400
2.1. Indications As a drug used in the diagnosis of pituitary function, endocrine metabolism, amino acid supplementation. Arbitol 400 has the main effect of coordinating in the treatment of liver dysfunction, helping to protect liver cells from damage. Support the treatment of hepatobiliary diseases that cause liver failure due to causes. Prevention of cirrhosis and liver damage in pre-cirrhotic alcoholics. 2.2. Contraindications Arbitol 400 should not be used in patients who are allergic to any of its ingredients. The patient has a severe allergic reaction. The patient has a disorder of the urea cycle and a deficiency of the enzyme arginase. Do not use Arbitol 400 for women who are pregnant or may become pregnant. 2.3. Drug side effects Some side effects of Arbitol 400 can occur without medical attention. These unwanted effects may go away during treatment as your body adapts to the medicine. In addition, your doctor can tell you about ways to prevent or reduce some of these side effects.
Redness or discoloration of the skin Swelling of hands and face Abdominal pain Thrombocytopenia Increased cyanosis of extremities Sickle cell anemia Increased serum creatinine Blood in urine Cough Difficulty swallowing Dizziness Rapid heartbeat Rash, itchy papules Pain or redness at the injection site Pale skin at the injection site Puffiness or swelling of the eyelids Chest tightness Unusual tiredness or weakness If you have any of the following overdose symptoms seek immediate medical attention and treatment Prompt treatment:
Deep or rapid breathing with dizziness Drowsiness Muscle tremor Numbness in the feet, hands or around the lips Rapid and deep breathing Restlessness Stomach cramps Overdose in children can lead to hyperchloremia metabolic, cerebral edema or possibly death 2.4. Drug Interactions Combined with thiazide diuretics, xylitol and aminophyline may increase plasma insulin concentrations May inhibit the response of plasma glucagon with long-term use of Arginin with antidiabetic agents oral sulfonylurea. For glucose-intolerant patients who are reintroduced to glucose, arginine's response to plasma insulin is reduced due to high phenytoin derivatives concentrations. The use of arginine in the treatment of metabolic alkalosis in patients with severe hepatitis who have recently received spironolactone may cause hyperkalemia.
Người bệnh nên dùng thuốc Arbitol theo chỉ định của bác sĩ
3. How to use arbitol 400
Arbitol 400 in the form of capsules to be taken orally twice a day, 1 tablet each time. Patients should take the drug with water and drink it before main meals or when symptoms appear.
In the process of using the drug, patients need to pay attention to a few things to avoid unwanted side effects”
Caution when using for lactating women Pay attention to the sugar content of the drug when using Arbitol 400 for patients with diabetes or patients requiring abstaining from sugar. Stopping if diarrhea occurs Arginin may change the ratio between extracellular potassium and intracellular potassium. In addition, plasma potassium concentrations may also be increased with the use of arginine in patients with renal impairment. Therefore, caution should be exercised when using Arbitol 400 in patients with kidney disease or dysuria. When high doses of arginine are used to treat acute ammoniaemia, hyperchloremic metabolic acidosis may occur. Therefore, plasma chloride and bicarbonate concentrations should be monitored and the corresponding amount of bicarbonate added at the same time. Arginin contains a high concentration of metabolic nitrogen, so the transient effect of high nitrogen on the kidney should be assessed before initiating arginine therapy. Arginin is not effective in the treatment of hyperammonemia due to dysorganic acidemia, and should not be used in such disorders. The above article has provided useful information about arbitol 400. Hopefully, it will help you answer the question "What is Arbitol?" and safe use of drugs, limiting the encounter with undesirable effects.
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