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In the liver, copper binds to ceruloplasmin to form ceruloplasmin which then releases it into the bloodstream. Up to 95% of copper in the blood is bound to ceruloplasmin. Therefore, to diagnose Wilson's disease or evaluate copper metabolism, your doctor will order a ceruloplasmin test.
1. What is Ceruloplasmin? The principle of action of ceruloplasmin
Copper is an indispensable substance in the human body, but if the body accumulates too much of this substance, it can cause poisoning and cause serious health consequences.Ceruloplasmin is a protein which contains copper, participates in the body's copper metabolism.
In the liver, copper binds to ceruloplasmin to form ceruloplasmin which then releases it into the bloodstream. Up to 95% of copper in the blood is bound to ceruloplasmin. Therefore, to diagnose Wilson's disease or evaluate copper metabolism, the doctor will order the ceruloplasmin test.
Ceruloplasmin was quantified via turbidimetric immunoassay. The concentration of Ceruloplasmin present in the test sample is directly proportional to the turbidity produced by the antigen-antibody immune complex.
2. When to do a ceruloplasmin test?
The doctor will order a ceruloplasmin test when the patient has clinical manifestations that are suspected of being caused by copper poisoning:
The patient has symptoms of abdominal pain, nausea, vomiting; Jaundice; Anemia ; Trembling hands and feet; Difficulty walking; Muscular dystonia ; Eating is difficult.
Để chẩn đoán bệnh Wilson hay đánh giá quá trình chuyển hóa đồng, bác sĩ sẽ cho chỉ định xét nghiệm ceruloplasmin
3. Technique for making ceruloplasmin
The technician takes 3ml of blood from a vein, puts it in a tube, the blood does not burst red blood cells. After taking blood, quickly centrifuge samples, separate serum or plasma. Store specimens stable at a temperature of 2-8 degrees for 3 days. Store samples from -15 to -25 degrees Celsius for 4 weeks. To ensure the best quality, samples should be analyzed within 2 hours, ensuring they reach room temperature prior to analysis. After collection, samples are transferred to the laboratory for analysis.
4. Ceruloplasmin test results
Test result ceruloplasmin normal value: 20 - 60 mg/dl Ceruloplasmin blood increased in case: The patient is pregnant, is taking birth control pills, has hepatitis, cirrhosis, cancer (bone, stomach, lungs), severe infection. Results of blood ceruloplasmin decreased in the case of patients with Wilson's disease, Menkes disease. Copper is absorbed through food daily. However, the body can inadvertently absorb copper through utensils and tools that come into contact with the outside, gradually accumulating and affecting health. Wilson's disease can be cured if detected early, so when you see abnormal symptoms in your body, you should go to the nearest medical facility for advice and examination. Currently, Vinmec International General Hospital is one of the leading prestigious hospitals in the country, trusted by a large number of patients for medical examination and treatment. Not only the physical system, modern equipment: 6 ultrasound rooms, 4 DR X-ray rooms (1 full-axis machine, 1 light machine, 1 general machine and 1 mammography machine) , 2 DR portable X-ray machines, 2 multi-row CT scanner rooms (1 128 rows and 1 16 arrays), 2 Magnetic resonance imaging rooms (1 3 Tesla and 1 1.5 Tesla), 1 room for 2 levels of interventional angiography and 1 room to measure bone mineral density.... Vinmec is also the place to gather a team of experienced doctors and nurses who will greatly assist in diagnosis and detection. early signs of abnormality in the patient's body. In particular, with a space designed according to 5-star hotel standards, Vinmec ensures to bring the patient the most comfort, friendliness and peace of mind.
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