What are the uses of Predsantyl?

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1. What is Predsantyl? What is Predsantyl 4mg used for?

1.1. Pharmacokinetics of Predsantyl Methylprednisolone - the main ingredient of Predsantyl 4mg drug has the general properties of the glucocorticoid prednisolone but is less soluble and more difficult to metabolize. Therefore, the drug Predsantyl has a longer-lasting effect. Methylprednisolone is a synthetic glucocorticoid and a methyl derivative of prednisolone methylprednisolone. This is a powerful anti-inflammatory agent with the ability to suppress the immune system.
Glucocorticoids work primarily by binding to, activating receptors on the inside of cells. Activated glucocorticoid receptors bind to the activating regions of DNA and activate transcription factors that induce gene inactivation through histone deacetylation in the nucleus of the cell.
Corticosteroids can affect the kidneys, water and electrolyte balance in the body, lipid, protein and carbohydrate metabolism, skeletal muscle, immune system, cardiovascular system, nervous system and the nervous system. Endocrine system.
1.2. Pharmacokinetics of Predsantyl Absorption: Methylprednisolone is rapidly absorbed and reaches peak plasma concentrations 1.5 to 2 hours after dosing in healthy adults. Distribution: Methylprednisolone has the ability to bind to plasma proteins, rapidly leaving the blood and distributed into body tissues, especially liver, kidney, skin, intestines, muscle with a volume of distribution of about 1.4 l/kg. The drug can cross the placenta and is distributed in small amounts into breast milk. Metabolism: Methylprednisolone is metabolized mainly in the liver and is also metabolised. Elimination: Methylprednisolone is excreted in the urine. The mean half-life of Methylprednisolone is longer than that of Prednisolone.

2. Indications of Predsantyl

Predsantyl 4mg medicine is indicated for use in the following cases:
Joint diseases such as rheumatism, juvenile arthritis, ankylosing spondylitis, rheumatoid arthritis. Inflammatory collagen leukemia: systemic dermatomyositis, lupus erythematosus, rheumatic heart disease, polymyositis. Skin disease: Common pemphigus. Chronic allergic rhinitis, severe seasonal atopic dermatitis, drug sensitization reactions, serum sickness, allergic contact dermatitis, bronchial asthma. Eye diseases such as sympathetic eye inflammation, keratitis, iritis, chorioretinitis, optic neuritis, allergic conjunctivitis, iridocyclitis. Respiratory pathology: sarcoidosis, disseminated tuberculosis, aspiration lung damage. Blood disorders: Autoimmune hemolytic anemia, thrombocytopenic purpura. Cancer: Malignant lymphoma, acute leukemia. Gastrointestinal diseases: Crohn's disease, inflammatory bowel disease. Meningococcal disease caused by tuberculosis. Prevention and treatment of transplant rejection.

3. Usage and dosage of Predsantyl

3.1. How to use Predsantyl Use Predsantyl with enough water, do not chew the tablet whole. The daily therapeutic dose can be taken as a single dose or divided into smaller doses.
The starting dose may vary depending on the pathology to be treated and should be maintained until a clinical effect is achieved. The average duration of treatment is from 3 to 7 days in cases of rheumatic diseases (except acute rheumatic diseases causing myocarditis), allergic diseases affecting the skin and respiratory tract, and eye diseases. If after 7 days there is still no clinical effect, the treating doctor will re-evaluate to determine the cause of the disease.
3.2. Dosage of Predsantyl The treatment dose for people with rheumatism is 16 to 24 mg per day, in case of internal organ damage, the therapeutic dose can be up to 60 mg per day. The initial dose of treatment for people with obstructive airways disease or asthma is 32 to 40 mg per day, then 8 mg every 4 days, the average duration of treatment is 3 to 4 weeks. The initial dose of treatment for people with interstitial lung disease is 32 to 40 mg per day, for a period of 1 week. The initial dose for people with pulmonary fibrosis is 24 to 32 mg per day, then gradually reduce to a maintenance dose of 4 to 8 mg per day. The initial dose of treatment for patients with sarcoidosis is 32 to 40 mg per day, which can be divided into 1 to 2 times. The initial dose to treat symptoms or signs of disease when allergic rhinitis, pollen allergy is 16mg per day, then lower 8mg every 4 days, treatment for 8 days if no good effect is seen. then continue therapy at a daily dose of 4 to 8 mg for 1 to 2 weeks. The initial dose when treating dermatological diseases is 80 to 160 mg per day depending on the condition of the disease, the dose can be reduced quickly and stopped after 2 to 4 weeks. The initial dose for the treatment of autoimmune diseases is 40 to 160 mg per day, then gradually reduce the dose when the maintenance dose is reached. The initial dose of treatment for people with autoimmune hemolytic anemia is 80 to 160 mg per day, then gradually reduce the dose to the maintenance dose. The initial dose for people treating Crohn's disease, duodenal ulcer, stomach is 40 to 60 mg per day, then gradually reduce the dose to the maintenance dose. Dosage for adrenocortical deficiency is 4 to 8 mg per day. 3.3. In case of overdose/forgotten dose of Predsantyl In case of overdose: Manifestations of an overdose of Predsantyl are similar to symptoms of side effects. Besides, you may experience liver and kidney toxicity. Patients should be closely monitored for skin, facial, blood pressure. Because the symptoms of Predsantyl poisoning are dangerous conditions that can progress very quickly. Ideally, the condition of the person using the drug Predsantyl overdose should be informed to the treating doctor for timely treatment.
In case of missed dose: avoid forgetting the dose; If you miss a dose, you need to skip the missed dose, do not overlap the dose with the next dose. You should absolutely not skip the dose more than 2 times in a row.

4. Undesirable effects of Predsantyl

Common side effects when using Predsantyl
Disruption of water and electrolyte balance, increased blood pressure, edema of the extremities, alkalosis. Increased risk of peptic ulcer disease, osteoporosis. During the course of treatment, if you notice any abnormal symptoms that are suspected to be caused by the use of Predsantyl 4mg, you need to consult your clinical pharmacist or treating doctor for possible treatment. timely and accurate.

5. Predsantyl drug interactions

When using Predsantyl with drugs such as phenytoin, primidone, rifampicin or other sedatives, it will cause an interaction that reduces the effect of corticosteroids, that is, reduces the effect of Predsantyl. When predsantyl is used with antacids and magnesium hydroxide or aluminum in people with chronic liver disease, the effect of methylprednisolone or predsantyl will be reduced, when the dose of treatment should be increased. When using Predsantyl with cardiac glycosides, Methylprednisolone will cause a potassium deficiency leading to the effect of glycosides. When Predsantyl is used together with laxatives or diuretics, it will increase potassium excretion. When using Predsantyl with Cyclosporine, there will be an interaction that causes myoclonus. You need to inform the treating doctor or pharmacist advising the health protection drugs or foods you are taking at this time to limit the occurrence of unintended drug interactions.

6. Notes when using Predsantyl

6.1. Contraindications Predsantyl Predsantyl 4mg is contraindicated in the following cases:
Hypersensitivity or local sensitivity to methylprednisolone or any of its ingredients. Systemic fungal infection. Systemic infections, except for people who have been/are being treated with specific drugs. Live virus vaccine or attenuated vaccine is being used in people who require anti-immunotherapy doses. 6.2. Predsantyl should be used with caution in patients with tuberculosis including latent or infectious tuberculosis, keratitis caused by Herpes simplex bacteria in the eye. Predsantyl should be used with caution in young children, with frequent and careful monitoring during long-term treatment. Care should be taken when using Predsantyl for pregnant women and during lactation, in cases where it is absolutely necessary to be used by a physician to weigh the benefits and risks. During treatment with Predsantyl do not stop treatment suddenly. During the use of Predsantyl, the user must strictly follow the dosage instructions of the treating doctor, avoid increasing or decreasing the therapeutic dose to speed up the treatment time. Before stopping using the drug, you need to consult your doctor. Effects on ability to drive and use machines: The effects of methylprednisolone on the ability to drive or use machines have not been systematically evaluated. The use of Predsantyl 4mg medicine may cause unwanted effects such as dizziness, lightheadedness, visual disturbances, fatigue... If you have this condition when taking the drug, you should not drive, operate machinery, working at height or other circumstances. Pregnancy: Methylprednisolone can cross the placenta. In studies, the use of corticosteroids in pregnant animals may cause fetal effects such as cleft palate, intrauterine growth retardation, and brain development. Long-term systemic use of methylprednisolone with the mother may lead to a slight decrease in infant weight. Lactation: Methylprednisolone is excreted in small amounts in breast milk by nursing women. Neonates of mothers taking high doses may have adrenal suppression, the drug should only be used in lactating women when the benefits of treatment outweigh the possible risks to the infant. . Predsantyl 4 mg has the active ingredient Methylprednisolone. Predsantyl 4 mg is available as a tablet and is taken orally. The drug is indicated in non-specific cases related to anti-inflammatory and immune. To ensure effective treatment and avoid side effects, patients need to take drugs according to prescription or consult a doctor, pharmacist for advice.
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