What are the uses of Micardis 40mg?

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The drug Micardis 40mg has the generic name telmisartan. This drug belongs to the group of drugs used to treat high blood pressure. At the same time, it is also a drug used in people over 55 years old with the aim to prevent cardiovascular problems such as heart attack, stroke, stroke...

1. Micardis 40mg drug belongs to which group?

Micardis 40mg belongs to the group of drugs for the treatment of essential hypertension, prevention of cardiovascular morbidity and mortality in patients 55 years of age and older at high risk of cardiovascular diseases. The drug has the main ingredient Telmisartan and many other excipients.

2. Effects of the drug Micardis 40mg

This is a drug with good effects when taken orally, specifically antagonizing the AT1 receptor of angiotensin II. Telmisartan is the main ingredient of Micardis 40mg that replaces angiotensin II, due to its high affinity for its binding site at the AT1 type receptor. This is the site of the proven effects of angiotensin II. Telmisartan binds selectively and persistently to the AT1 receptor.
The active ingredient Telmisartan does not act synergistically with the partial AT1 receptor. Telmisartan has no affinity for other receptors, including the AT2 receptor and other less atypical AT receptors. Telmisartan is effective in reducing plasma aldosterone concentrations. Telmisartan does not inhibit human plasma renin activity or block ion channels. Telmisartan is not an angiotensin-converting enzyme inhibitor. This is the enzyme that degrades bradykinin (kininase II). Therefore, Micardis 40mg is unlikely to cause bradykinin-mediated undesirable effects.
In the human body, two doses of Micardis 40mg have almost completely inhibited angiotensin II-induced hypertension. This inhibitory effect is maintained for 24 hours and has the potential for effects for up to 48 hours.

Micardis 40mg is indicated for use in the following cases:
Drugs used in the treatment of idiopathic hypertension. Prevention of cardiovascular disease and mortality in people 55 years of age and older at high risk of cardiovascular disease.

3. Dosage of Micardis 40mg

3.1. Dosage for adults Drugs used in the treatment of essential hypertension The recommended dose is 1 tablet of Micardis 40mg x 1 time / day. May be effective at a lower dose of 20 mg/day in some people. The drug can be increased to a maximum of 2 Micardis 40mg tablets ie 80mg once a day to achieve the target blood pressure.
When taking Micardis 40mg, the specialist may prescribe a combination with thiazide diuretics such as hydrochlorothiazide. This combination has shown that hydrochlorothiazide has a synergistic antihypertensive effect with the drug telmisartan. When a dose increase is required, it should be borne in mind that the maximum antihypertensive effect is usually achieved 4–8 weeks after initiation of therapy.
For those suffering from grade 3 hypertension, treat Micardis 40mg in doses up to 160mg alone; Co-administration with hydrochlorothiazide 12.5–25 mg/day responds to treatment.
Prevention of cardiovascular disease and death The recommended dose of 2 Micardis tablets 40mg once daily is effective in preventing cardiovascular morbidity and mortality.
It is recommended that you self-monitor your blood pressure when starting treatment with Micardis 40mg to prevent cardiovascular morbidity and mortality and, if necessary, adjust the dose to achieve hypotension.
Renal impairment No dosage adjustment is required in patients with renal impairment including those on hemodialysis. The activity of Telmisartan is not removed from the body by dialysis.
Hepatic impairment Do not take more than 1 tablet of Micardis 40mg once a day in people with mild and moderate hepatic impairment.
For the elderly group, no dose adjustment is required.
3.2. Dosage in Children and Adolescents At present, the safety and effectiveness of Micardis have not been established for use in children under 18 years of age.
Note when using: The above dosage is for reference only. The specific dosage depends on the individual condition and the progression of the disease. To get the right dose, you need to consult a Cardiologist or medical professional.

4. What to do in case of an overdose of Micardis 40mg

The most obvious signs of an overdose of Micardis 40mg are hypotension and tachycardia and bradycardia may also occur.
You should receive supportive treatment if there are symptoms of hypotension. Telmisartan is not eliminated from the body during hemodialysis or cyclic dialysis.

5. Notes when using Micardis 40mg

5.1. Cases needing attention when using the drug People with hypersensitivity to the active ingredient Telmisartan or to any of the excipients of Micardis 40mg Women who are pregnant in the second and third months of pregnancy. Women are breastfeeding. People who are suffering from obstructive diseases of the bile ducts. Severe liver failure. Concomitant use of Micardis 40 mg with aliskiren is contraindicated in patients with diabetes mellitus or on treatment for renal failure (with GFR < 60 mL/min/1.73 m2). Contraindicated for use in people with rare hereditary conditions that may not be compatible with an excipient of the drug. Are taking other medications (including prescription and over-the-counter drugs, herbs and supplements); 5.2. Pregnancy and breast-feeding For women planning pregnancy, it is advisable to switch to alternative antihypertensive therapies for which safety data is established during pregnancy. Unless otherwise indicated, continued use of the angiotensin II receptor antagonist Micardis 40 mg is deemed absolutely necessary.
Once a woman has been diagnosed as pregnant, immediately stop treatment with angiotensin II receptor antagonists including Micardis 40mg and if necessary initiate an alternative course of treatment.
Knowing the information about the drug Micardis 40mg will help the process of use be more effective and reduce the risk of side effects.

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