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Tanasolene drug has the main active ingredient is Alimemazine and other excipients in sufficient quantity. It is an antiallergic and is used in cases of hypersensitivity.
1. What is Tanasolene?
Drugs: Drugs belonging to the group of anti-allergic and treatment in cases of hypersensitivity. The dosage form of the drug is: Film-coated tablet form. Packing: Box of 2 blisters x 25 tablets, Box: 10 blisters x 25 tablets. Active ingredients are: Alimemazine tartrate 5mg. 1.1. Pharmacodynamics of the drug Tanasolene: Alimemazine is an H1 receptor antagonist, a sedative.
1.2. Pharmacokinetics of the drug Tanasolene Pharmacokinetics Alilmemazine is rapidly absorbed from the gastrointestinal tract. After taking the drug from 15 to 20 minutes, the drug takes effect and lasts 6-8 hours. The plasma half-life is 3.5 – 4 hours; It is about 20-30% bound to plasma proteins. Alimemazine is excreted by the kidneys as sulfoxide metabolites (70-80%, after 48 hours).
1.3. The effect of the drug Tanasolene Pharmacology Alimemazine is a derivative of Phenothiazines, has strong anti-histamine and anti-serotonin effects. In addition, the drug also has sedative, antitussive, and antiemetic effects. Drug substance Alimemazine competes with Histamine at the H1-histamine receptors, so it has an H1-antihistamine effect. The drug antagonizes most of the pharmacological effects of histamine, including urticaria and pruritus. The peripheral anticholinergic effect of the drug is relatively weak, however, it has been observed in some patients treated with the specific drug Alimemazine such as dry mouth, blurred vision, urinary retention and constipation. Alimemazine has a sedative effect caused by inhibition of the enzyme histamine N - methyltransferase and by blocking central histamine-secreting receptors concurrently with effects on other receptors, especially serotoninergic receptors. This effect is also the basis for using Alimemazine as a pre-anesthetic drug. Alimemazine has an antiemetic effect: The mechanisms of this effect are not completely known. The antiemetic effect may be due to the direct effect of the drug on the chemosensitive center of the spinal cord and blocking the dopaminergic receptors in this region.
2. What are the uses of Tanasolene?
Tanasolene medicine is used to treat the following diseases:
Treatment of symptoms of allergic manifestations: Respiratory allergies (sneezing, rhinitis, runny nose), conjunctivitis and skin inflammation (itching, urticaria). . Vomiting is frequent in children. Insomnia in children and adults. Relieves dry cough and cough caused by irritation, especially when coughing in the afternoon or at night. The state of acute delirium due to alcohol withdrawal. Adhering to the use of Tanasolene according to the indications, including the uses and functions for the subjects listed on the instruction sheet for using Tanasolene or the doctor's prescription.
3. Undesirable effects of the drug Tanasolene
During the use of Tanasolene, patients may experience some of the following side effects:
Common unwanted effects: Fatigue, drowsiness, headache, mild dizziness, dry mouth, thick phlegm or sleepy. Uncommon side effects: Constipation, urinary retention, eye accommodation disorder. Usually, the side effects or unwanted effects, unwanted effects will gradually decrease and disappear completely after stopping taking the drug. If there are rare unwanted effects that are not mentioned in the instruction sheet, you need to actively contact your treating doctor for specific and appropriate treatment.
4. Tanasolene drug interactions
The CNS depressant effect of the drug Tanasolene will be enhanced by: alcohol, barbituric sleeping pills or other sedatives. Respiratory muscle suppression has also been observed with these drugs in combination and potentiates the antihypertensive effect. Anticholinergic effects of Alimemazine are increased when co-administered with other anticholinergics leading to constipation. seasick. Alimemazine antagonizes the therapeutic effects of active ingredients Amphetamine, Levodopa, Clonidine, Guanethidine, Adrenalin Some drugs that prevent the absorption of active ingredients Alimemazine are antacids, drugs to treat Parkinson's disease, Lithium. Consider taking Tanasolene with alcohol, tobacco, alcoholic or fermented beverages. These agents can change the ingredients in the medicine. See details in the leaflet or consult your treating physician or healthcare professional for more details.
5. Some notes when using the drug Tanasolene
5.1. Contraindications of the drug Tanasolene People with sensitive or hypersensitivity to antihistamines. Do not use in people with liver or kidney dysfunction, epilepsy, Parkinson's disease, hypothyroidism, pheochromocytoma, myasthenia gravis. Do not use Tanasolene in cases of overdose due to barbituric, opiate, alcohol. Patients with a history of granulocytosis associated with phenothiazine derivatives. People at risk of urinary retention related to prostatic urethral disorders. People at risk of closed-angle glaucoma. Children under the age of 6 years. Women who are pregnant or breastfeeding. 5.2. Notes and precautions when using Tanasolene Be careful when treating the elderly with Tanasolene, especially when it is too hot or too cold (causes orthostatic hypotension, dizziness, drowsiness, constipation). Active ingredient Alimemazine can affect skin test reactions to allergens, avoid using alcohol-containing products such as alcohol or CNS depressants. Use caution when using Tanasolene for people with cardiovascular disease. Note during pregnancy: Pregnant women taking Tanasolene need to be reminded and consult a doctor or pharmacist before taking the drug. Even tested drugs still have risks when used. Note the breastfeeding period: Breastfeeding mothers need to be carefully advised by their doctor about the benefits and risks for mother and baby. Do not arbitrarily use Tanasolene without carefully reading the instructions for use and instructions of the doctor to protect the mother and baby. This is an antiallergic drug and is used in cases of hypersensitivity. To ensure effective treatment, patients need to take medicine according to prescription or consult a doctor, professional pharmacist.
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