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The drug Alorax has the main ingredient Loratadin, manufactured by Pymepharco Joint Stock Company. Alorax is used as an anti-allergic drug, indicated for the treatment of certain diseases such as rhinitis or atopic dermatitis,...
1. The effect of the drug Alorax 10mg
Alorax is indicated in the following cases:
Chronic rhinitis, allergic rhinitis sneezing, itchy nose, runny nose, seasonal allergic rhinitis; Allergic conjunctivitis : Itching and burning eyes; Atopic dermatitis, chronic urticaria and allergic skin disorders. Pharmacodynamics:
Loratadin is a tricyclic antihistamine, it has long-acting selective antagonism on peripheral H1 receptors; Anti-itch and urticaria related to histamine, fast acting, but especially no sedative effect. It is the drug of first choice for the treatment of allergic rhinitis or allergic urticaria; Relief of symptoms of rhinitis and allergic conjunctivitis due to the release of histamine. Loratadine can be combined with Pseudoephedrine hydrochloride for the purpose of alleviating symptoms of nasal congestion in the treatment of allergic rhinitis with nasal congestion.
Pharmacokinetics:
Loratadine is rapidly absorbed after oral administration, mean peak plasma concentrations of Loratadine and its active metabolite (Descarboethoxyloratadine) are 1.5 and 3.7 hours, respectively. Up to 97% of Loratadine is bound to plasma proteins; Loratadine clearance is 57 - 142 ml/min/kg. The volume of distribution of Loratadine is 80 - 120 liters/kg; Approximately 80% of the total dose of Loratadine is excreted equally in the urine and faeces as metabolites within 10 days; Thanks to the cytochrome P450 microsomal enzyme system, Loratadine will be extensively metabolized by the liver. Loratadine will mainly be metabolized to Descarboethoxyloratadine. This is a pharmacologically active metabolite; The antihistamine effect of the drug appears within 1-4 hours after taking Loratadine. Reaches maximum after 8 - 12 hours and lasts more than 24 hours. By approximately day 5 of dosing, concentrations of loratadine and descarboethoxyloratadine should reach steady state in the majority of patients. Side effects of the drug Alorax 10mg:
The drug Alorax 10mg contains Loratadin which does not cause drowsiness at a daily dose of 10mg. Some rare side effects such as nausea, gastritis, fatigue, headache, dry mouth, digestive upset, and allergic symptoms such as rash. When experiencing these symptoms after taking the drug, you should notify your doctor/pharmacist for timely handling.
2. Dosage of the drug Alorax 10mg
How to use Alorax 10mg:
Alorax 10mg Pymepharco long tablets for oral use. Dosage of Alorax 10mg:
For adults and children over 6 years old: 1 tablet x 1 time/day; For children 2 - 5 years old: 2 tablets x 1 time/day; For patients with liver failure: 2 tablets x 1 time / day, or 1 tablet every 2 days. In case of overdose:
Adults, when taking an overdose of Loratadin tablets (40 - 180 mg), there are some manifestations such as: Drowsiness, tachycardia, headache; Children: Extrapyramidal manifestations and palpitations may be observed after an overdose of syrup (in excess of 10 mg). So how to deal with an overdose?
Alorax is usually a drug for symptomatic and supportive treatment. In case of acute Alorax overdose, treat with emesis with syrup of ipeca to empty the stomach immediately. Administration of activated charcoal after induction of vomiting may be helpful to prevent absorption of loratadine.
If inducing measures are ineffective or contraindicated (eg, the patient has fainting, convulsions or lack of vomiting reflex), then gastric lavage with 0.9% NaCl solution can be performed. And combined with endotracheal intubation to prevent aspiration of gastric juice.
In case of missed dose:
If you miss a dose, the best way to handle it is to take it as soon as possible. In case the missed dose is close to your next dose, skip the missed dose and take your next dose at the scheduled time. Never take twice the prescribed dose.
3. Notes of the drug Alorax 10mg
To use the drug safely, you need to carefully read the instructions for use before using and refer to some of the information below.
Alorax 10mg is contraindicated in some of the following cases:
People who are sensitive to the ingredients of the drug; Children under 2 years old. Use with caution in pregnancy and lactation:
During pregnancy: There have not been any adequate and well-controlled studies of the use of Loratadine during pregnancy. Therefore, you should only take Loratadin during pregnancy when absolutely necessary, in low doses and for a short time. Lactation: Loratadine and its metabolite Descarboethoxyloratadine are excreted in human milk. If Loratadine is to be used in a nursing woman, Loratadine should only be used in low doses and for short periods of time. Caution should be exercised when administering Alorax to patients with hepatic impairment.
Concentration:
In clinical trials, there was no impairment in driving ability in patients receiving Loratadine. However, it is still very important for patients to be informed that it is very rare that drowsiness may affect the ability to concentrate during certain activities such as driving or operating machinery. Drug Interactions:
When Loratadine is used concomitantly with Ketoconazole, Erythromycin or Cimetidine, the plasma concentration of Loratadine will be increased. But there were no clinically or biochemically significant changes (including electrocardiogram). In summary, Alorax is an anti-allergic drug, used in some cases such as allergic rhinitis, contact dermatitis, conjunctivitis, chronic urticaria, ... However, to use the drug most effectively And to avoid unwanted side effects, you should consult your doctor/pharmacist before taking.
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