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Posted by Pharmacist Nguyen Le Trang - Faculty of Pharmacy, Vinmec Times City International General Hospital
Loratadine is a long-acting, long-acting peripheral selective histamine H1 receptor antagonist, belonging to the 2nd generation.
1. Indications for drug use
The drug only works to relieve symptoms, not to cure the cause of some diseases such as: allergic rhinitis, allergic conjunctivitis, itching and histamine-related urticaria. The drug has no protective or supportive effect in cases of severe histamine release such as anaphylaxis.
2. Be careful when using drugs
Patients with severe hepatic impairment should be given a lower starting dose (eg 5mg or 10mg every 2 days). Loratadine should only be used in pregnant and lactating women if absolutely necessary, in low doses for a short period of time.
3. Dosage – how to use
Take orally. Available in the form of tablets, suspension, and oral syrup. Can be taken with or without meals.
Adults: 10 mg/time/day. In urticaria, if the dose of 10mg does not provide good control of symptoms, it can be increased to 10mg twice daily.
Children: Should use syrup form 2 - 12 years old (< 30 kg): 5 mg / time / day, (> 30 kg): The same dose as adults.
4. Unwanted effects and attention when using
Common : Fatigue, dizziness, headache, nausea, dry mouth.
Uncommon : Increased liver enzymes.
Rare: Hypersensitivity reactions, tachycardia, nausea, vomiting.
The drug does not pass through the blood-brain barrier, so it does not cause drowsiness like the 1st generation H1 antihistamines.
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