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Savi day medicine is made in the form of tablets, with the main ingredients including Paracetamol, Dextromethorphan hydrobromide and Loratadin. The drug is used to treat the symptoms of colds and flu.
1. Uses of cold medicine Savi Day
What is Savi Day? Savi Day medicine has the main ingredients including Paracetamol 500mg, Dextromethorphan hydrobromide 15mg and Loratadin 5mg. In particular, the uses of each ingredient are as follows:
Paracetamol : Is an active metabolite of phenacetin, a drug with effective analgesic - antipyretic effects. Paracetamol helps reduce body temperature in people with fever by acting on the hypothalamus causing hypothermia, heat loss due to vasodilation, and increased peripheral blood flow; Dextromethorphan hydrobromide is a cough suppressant that acts on the cough center in the medulla oblongata. Dextromethorphan is used for the temporary relief of coughs caused by mild throat and bronchial irritations such as colds or inhalation of irritants. Dextromethorphan is most effective in the treatment of chronic, non-sputum cough. This drug is often used in combination with many other drugs in the symptomatic treatment of diseases of the upper respiratory tract; Loratadine: A tricyclic antihistamine with long-acting selective peripheral H1-receptor antagonism with no CNS depressant effects. Loratadine relieves symptoms of rhinitis and allergic conjunctivitis by releasing histamine. In addition, Loratadine is also effective against itching and urticaria related to histamine. Indications to use Savi Day:
Treatment of flu symptoms: Cough, fever, headache, bone and joint pain, muscle pain, nasal congestion, runny nose, rash, watery eyes; Reduce pain, reduce fever in cases of body aches, colds, runny nose, cough, chills. Contraindications to using Savi Day:
Patients with respiratory failure; Children under 12 years old; People who are sensitive to ingredients/excipients in the drug; The patient is taking or has used an MAO inhibitor in the last 2 weeks; People with severe liver disease or hepatocellular insufficiency; Patients with G6PD deficiency; The patient is often anemic, has liver, lung, heart or kidney disease.
2. How to use and dose Savi Day
Usage: Orally.
Dosage:
People over 12 years old: Take 1 tablet/time. If necessary, you can take 1 more tablet in the afternoon and 1 tablet in the afternoon. Each pill should be taken at least 4 hours apart; Elderly people (over 65 years old): Take medicine as directed by your doctor; Patients with severe renal impairment (creatinine clearance less than 10ml/min): The interval between doses should be more than 8 hours. Overdose: When using Savi Day in an overdose, after 2-3 hours of taking a toxic dose of the drug, the patient has symptoms of nausea, vomiting, blurred vision, drowsiness, nystagmus, numbness, and hallucinations. , urinary retention, ataxia, convulsions, respiratory failure, tachycardia, headache, extrapyramidal manifestations, palpitations, abdominal pain,... In severe poisoning, patients may have Central nervous system preference, delirium and agitation. Then there is CNS depression, hypothermia, stupor, fatigue, rapid and shallow breathing, weak and rapid or irregular pulse, low blood pressure, circulatory failure,...
If vasodilation is severe , the patient may go into shock, convulsions, suffocation, fatal coma,... After 2-4 days of taking toxic doses, clinical signs of liver damage may appear. In addition, the patient also has an increase in plasma aminotransferase, increased concentration of bilirubin in the blood plasma. When liver damage is extensive, prothrombin time is prolonged. Some patients may develop acute renal failure.
Management includes symptomatic and supportive treatment. It is necessary to immediately induce vomiting, wash the stomach - intestines, use the antidote N-acetylcysteine orally or injected at the right time to prevent hepatotoxicity, combined with appropriate monitoring. Because activated charcoal can interfere with the absorption of oral N-acetylcysteine, when using activated charcoal, use the intravenous form of N-acetylcysteine to achieve detoxification effect. If induction of vomiting is unsuccessful or contraindicated (due to fainting, convulsions, lack of vomiting reflex), gastric lavage with 0.9% sodium chloride solution and endotracheal intubation can be used to prevent risk of aspiration of gastric juice.
3. Savi Day drug side effects
When using Savi Day, patients may experience some side effects such as:
Side effects of Paracetamol include: Skin rash, nausea, vomiting, pancreatitis, hematopoietic disorders,... Symptoms Symptoms are usually quite mild. In addition, the patient also has thrombocytopenia, neutropenia, pancytopenia, agranulocytosis,... The patient may experience hypersensitivity reactions such as dyspnea, urticaria, hypotension. blood pressure,...; Side effects of Dextromethorphan include: Fatigue, dizziness, nausea, skin flushing, tachycardia. At very high doses, patients may experience central nervous system depression and mental confusion, respiratory depression; Side effects of Loratadine include: Fatigue, dry mouth, headache, gastrointestinal disturbances (nausea, gastritis), allergic symptoms (rash). The elderly and children are more sensitive to the systemic effects of Savi Day. When experiencing side effects of the drug, the patient should immediately notify the doctor to receive advice and appropriate treatment.
4. Be careful when using Savi Day medicine
Some notes patients need to remember before and while using Savi Day medicine are:
Do not use Savi Day medicine to treat fever alone; Do not use Savi Day for more than 5 days to treat pain. If symptoms do not improve or when the patient coughs for more than 1 week with fever, develops high fever, skin rash, persistent headache, cough with sore throat, consult a doctor; Do not use Savi Day at the same time as any other medicine containing Paracetamol because an overdose can be dangerous to the patient; Patients with severe kidney failure or liver cell insufficiency should consult a doctor before taking Savi Day; Caution should be exercised when using Savi Day in patients with pre-existing anemia, as cyanosis may not be evident. At the same time, drinking a lot of alcohol can increase the toxicity of Paracetamol to the liver, so avoid or limit drinking alcohol while taking the drug; Doctors should warn patients about symptoms of toxic skin necrosis syndrome, Stevens-Johnson syndrome, acute exanthematous pustulosis syndrome when taking Savi Day; When using Savi Day, patients have an increased risk of dry mouth and tooth decay (especially the elderly), so they need to keep their teeth clean during the course of using the drug; Use caution when using Savi Day in patients with asthma, respiratory failure; Elderly people, pregnant or lactating women should consult their doctor before taking Savi Day; Savi Day medicine can cause dizziness, drowsiness, so be careful with machine operators, drivers, ...
5. Savi Day drug interactions
Some drug interactions of Savi Day include:
In patients who are taking anticoagulants, regular use of Paracetamol can slightly increase prothrombin time; Phenobarbital increases the activity of microscopic enzymes in the liver, produces toxic metabolites, increases the hepatotoxicity of Paracetamol if Phenobarbital is used concurrently during an overdose of Paracetamol (easy to cause liver necrosis); Using Paracetamol can distort blood uric acid quantitative tests and blood glucose quantitative tests; Dextromethorphan interacts with central nervous system depressants, neuroleptics, antidepressants, phenothiazines,... if used concurrently; Avoid concomitant use of Savi Day with MAO inhibitors. Antihistamines should be discontinued at least 48 hours before skin tests are performed because they can cause erroneous results. Patients need to strictly follow the doctor's instructions when using Savi Day to ensure the effectiveness of the drug and significantly reduce the risk of dangerous side effects.
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