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Zytovyrin S drug contains the main active ingredients are Ezetimibe, Simvastatin and many other ingredients that have the effect of reducing bad cholesterol, lowering blood fat, preventing stroke and other cardiovascular diseases. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to take the drug exactly as directed by a doctor or pharmacist.1. What is Zytovyrin S?
What is Zytovyrin S? The drug has the main ingredients Ezetimibe 10mg, Simvastatin 20mg and excipients just enough for 1 tablet.
Effect of the main ingredient in the drug formula Zytovyrin S
Ezetimibe
Has the effect of inhibiting cholesterol absorption but does not affect the absorption of fatty acids, bile or fat-soluble vitamins such as: A, D, E Reduces synthesis and transport of cholesterol from the intestines to the liver. Simvastatin:
Active ingredient c. This is an enzyme that catalyzes the metabolism of cholesterol. Increases good cholesterol (HDL), reduces bad cholesterol and fats (LDL, Triglycerides).
2. Indications and contraindications to the use of Zytovyrin
2.1. Indications Zytovyrin S is used together with a diet to help lower total cholesterol, lower blood triglycerides in the following cases:
Primary hypercholesterolemia Mixed dyslipidemia. 2.2. Contraindications Zytovyrin S is contraindicated in the following cases:
Patients with hypersensitivity to any ingredient of the drug. People with a history of chronic liver disease, persistent elevation of Transaminases with no known cause. People who are taking strong inhibitors of CYP3A4. Pregnant and lactating women. Myopathy secondary to the use of other lipid-lowering drugs. Contraindicated in combination with drugs: Verapamil, Dronedaron, Diltiazem.
3. Dosage and how to use Zytovyrin
3.1.How to use Zytovyrin S Patients should pay attention, when using the drug should have a diet containing low cholesterol, and maintain throughout the treatment period. Patients should be treated with the lowest effective dose. Increase the dose of Zytovyrin S slowly according to the needs and response of each patient, each dose increase at least 4 weeks apart. Special attention should be paid to monitoring reactions, unwanted side effects of the drug. Use Zytovyrin S medicine >2 hours before or >4 hours after taking a bile acid absorber. 3.2. Dosage The usual dose of Zytovyrin S is 1 tablet / day and used in the evening. After 2 weeks, it is necessary to monitor blood lipid levels and adjust drug dosage if necessary.
If used in combination with Amiodarone or Amlodipine, the patient should pay attention not to use more than 1 tablet/day.
It should be noted: The above drug dosage is for reference only, patients need to strictly follow the dosage and instructions of the doctor, professional pharmacist.
4. How to handle when you miss a dose, overdose Zytovyrin WILL
In case of missed dose or overdose, the patient should pay attention:
Missed dose: In case of forgetting a dose, the patient should take it as soon as he remembers. However, if it is almost time for the next dose of Zytovyrin S, the patient should skip the missed dose. Never take a double dose to make up for the previous dose. Overdose: Overdose of Zytovyrin S drug usually does not cause serious side effects, patients can recover without leaving complications. Therefore, to ensure safety, patients should soon go to medical centers for examination and treatment.
5. Undesirable effects of the drug Zytovyrin WILL
Zytovyrin S is well tolerated, so the side effects when using Zytovyrin S are usually very mild and only transient.
Common effects: Headache, muscle pain, diarrhea, upper respiratory tract infection, allergies, increased liver enzymes, urticaria, facial swelling... Muscle problems: Muscle atrophy, myositis, kidney failure, hypothyroidism Liver: Jaundice, dark urine, fatigue.. The above side effects do not list all the side effects when using Zytovyrin S. Therefore, in the process of using Zytovyrin S, the patient encounters any adverse effects, please inform the doctor. qualified doctor or pharmacist for appropriate assistance.
6. Zytovyrin drug interactions
Using Zytovyrin S with other drugs can cause drug interactions. Therefore, you need to know the following drug interaction information:
Do not combine and use Zytovyrin S with strong CYP3A4 inhibitors, Dronedaron, Verapamil, Diltiazem. Using Zytovyrin S with Amiodarone: If you take more than 20mg/day Simvastatin may increase the risk of myopathy, myopathy. Fibrates used with Zytovyrin S can increase the concentration of Ezetimibe by 1.5-1.7 times. Concomitant use of Cholestyramine may decrease the bioavailability of Ezetimibe. Moderate calcium channel blockers, CYP3A4: May increase the risk of myopathy, myopathy. Fusidic Acid: Increases mild myopathy. Anticoagulants used concurrently with Zytovyrin S: Increases anticoagulant effect. High doses of colchicine, niacin, and Zytovyrin S may increase the risk of muscle damage. Because of the dangerous drug interactions, the patient should inform the doctor/pharmacist of the drugs and dietary supplements they are taking for advice on possible interactions.
7. Note when using Zytovyrin drug
During the use of Zytovyrin S, patients should pay attention to the following issues:
Pregnant women: Zytovyrin S is not used for pregnant women. Therefore, if you suspect or intend or are planning to become pregnant, discontinue Zytovyrin S immediately until it is determined that you are not pregnant. Lactation: Animal studies have shown that the drug may be excreted in breast milk. Therefore, nursing mothers should not use Zytovyrin S. People who drive and operate machinery: Zytovyrin S may cause headaches and dizziness. This affects the ability to drive and use machines. Therefore, patients need to be careful when using it on this group of subjects. Before treatment with Zytovyrin S, the patient should be tested for liver enzymes. In addition, the patient needs to monitor the Creatin Kinase index in the following cases::
The patient has impaired renal function, hypothyroidism or a history of hereditary myopathy, Statin-related myopathy, liver disease , rhabdomyolysis,... If the CK test result is > 5 times the normal limit, the patient should not use Zytovyrin S. While using Statins, you should notify your doctor immediately if you have symptoms of pain. muscle stiffness, muscle weakness... and test CK for timely treatment. Patients should stop taking the drug a few days before major surgery or clinical examination. To ensure the best drug quality, patients need to store Zytovyrin S in a cool, dry place, away from direct light. In addition, it should be kept away from the reach of children and pets. The storage temperature is below 30 degrees Celsius. Do not use Zytovyrin S when there are signs of damage, past the expiry date. In summary, Zytovyrin S drug contains the main active ingredients Ezetimibe, Simvastatin and many other ingredients that have the effect of reducing bad cholesterol, lowering blood fat, preventing stroke and other cardiovascular diseases. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to take the drug exactly as directed by a doctor or pharmacist.
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