Precautions when using blood fat lowering drug rosuvastatin

This is an automatically translated article.

The article was written by Pharmacist Pham Thi Kim Dung - Faculty of Pharmacy - Vinmec Times City International General Hospital
Rosuvastatin, taken with diet, is a medicine that lowers bad cholesterol (LDL), raises good cholesterol (HDL), and lowers triglycerides (a form of fat in the blood). Rosuvastatin belongs to the group of statin drugs.

1. Mechanism of action of Rosuvastatin?

Rosuvastatin competitively and selectively inhibits the enzyme HMG-CoA reductase, the enzyme that catalyzes cholesterol synthesis. The main site of action of rosuvastatin is the liver, the target organ of cholesterol lowering.
Indirectly, Rosuvastatin increases the absorption and catabolism of LDL bad fats and inhibits the synthesis of VLDL in the liver.
Rosuvastatin lowers Total Cholesterol, LDL, VLDL, Apo B, nonHDL and triglycerides and increases HDL-cholesterol (good cholesterol) in patients.

2. Cases of contraindications to the use of Rosuvastatin

Pregnancy and breast-feeding Patients with known allergy to rosuvastatin or any of its ingredients Patients with progressive liver disease, including unexplained elevated liver enzymes.

3. Note when using Rosuvastatin blood fat lowering drug?

Rosuvastatin can be taken at any time of the day and is independent of food.
Patients should be monitored for liver enzymes and creatinine kinase (CK) levels during long-term use of rosuvastatin.
It is necessary to closely monitor for adverse reactions during drug administration. Patients should be asked to report to their doctor immediately any unexplained muscle pain, stiffness, weakness, or cramps, especially if accompanied by fatigue, fever, dark urine, nausea or vomiting during drug use.

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References:
IBM Micromidex : Rosuvastatin calcium Mims.com: Crestor Drugs.com