Uses of Zlatko 100

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Zlatko 100 is a new antidiabetic drug that lowers blood sugar by a different mechanism than previous antidiabetic drugs. For more information about the drug, please refer to the article below.

1. Uses of Zlatko 100


The main ingredient of Zlatko 100 is Sitagliptin 100mg, which is prepared in the form of film-coated tablets. Sitagliptin is a medicine in a class of drugs that treat high blood sugar, called dipeptidyl peptidase 4 (DPP-4) inhibitors. The drug works to lower blood sugar in patients with type 2 diabetes by increasing levels of the hormone incretin.
Incretin hormones including glugacon-like peptide-1 (glugacon-like peptide-1: GLD-1) and glucose-dependent insulinotropic polypeptide: GID, are released from the intestinal tract throughout the day and are especially elevated after meal. These incretin hormones are components of the endogenous system involved in the physiological regulation of glucose homeostasis by increasing insulin levels and decreasing blood glucagon concentrations. However, after the creation of the hormone incretin is rapidly hydrolyzed by the DPP-4s.
Sitagliptin drug prevents DPP-4 from hydrolyzing the hormones incretin, thereby increasing the concentration of the active forms of the two hormones GLP-1 and GIP in the blood plasma. Due to increased levels of active incretin, sitagliptin increases insulin release and decreases glucagon levels in a glucose-dependent manner.
For patients with type 2 diabetes with hyperglycemia, this change in insulin and glucagon levels leads to a decrease in hemoglobin A1c (HbA1c) and a decrease in fasting or postprandial glucose. This glucose-dependent mechanism of sitagliptin is distinct from that of hypoglycaemic sulphonamides, since hypoglycaemic sulphonamides increase insulin secretion even at low glucose concentrations and the potential for hypoglycemia in patients with type 2 diabetes. In a study in healthy subjects, Sitagliptin did not lower blood sugar and did not cause hypoglycaemia. After oral administration, the drug Zlatko is rapidly absorbed from the gastrointestinal tract and food does not affect the absorption and effects of the drug.

Thuốc Zlatko 100 có thành phần chính là Sitagliptin 100mg
Thuốc Zlatko 100 có thành phần chính là Sitagliptin 100mg

2. Indications and contraindications of the drug Zlatko 100


Zlatko 100mg is indicated for use in the following cases:
Single treatment for the control of type 2 diabetes mellitus (non-insulin dependent diabetes mellitus) in combination with diet and exercise. In combination with other oral antidiabetic agents for the control of type 2 diabetes in patients whose blood glucose levels are not controlled on monotherapy or for dual therapy oral antidiabetic effect. Combination with insulin: When using insulin, blood glucose cannot be controlled. Contraindicated to use Zlatko drug in the following cases:
Hypersensitivity to the active ingredient sitagliptin or hypersensitivity to any component of the drug. Type 1 diabetes or insulin dependent diabetes. Like other antidiabetic drugs, Zlatko is not indicated for use in type 1 diabetes. People with diabetes have ketoacidosis.

3. Dosage and usage of the drug Zlatko 100mg


How to use: The drug is taken orally and can be taken before or after meals. Patients should drink at a time to increase effectiveness.
Dosage:
The recommended dose is Zlatko 100 mg/day when used as monotherapy or in combination with other antidiabetic agents. When sitagliptin is used in combination with a sulphonamide, a lower dose of a sulphonamide may be considered to reduce the risk of hypoglycaemia due to a hypoglycaemic sulphonamide. Patients with renal impairment:
Mild renal impairment (creatinine clearance ≥ 50mL/min): No dose adjustment is required. Moderate renal impairment (30 ≤ creatinine clearance < 50 mL/min): 50 mg/day/time. Severe renal impairment (creatinine clearance < 30 mL/min), or end-stage renal disease requiring hemodialysis or peritoneal dialysis: 25 mg once daily. Sitagliptin can be used at any time, regardless of the timing of hemodialysis. Patients with hepatic impairment: No dose adjustment is required.
Elderly people adjust dosage according to renal function. Because dose adjustment is based on renal function, renal function should be assessed prior to initiation of therapy and periodically thereafter.
Children: Not for use by people under 18 years of age because safety and effectiveness have not been tested.
Overdose: In clinical trials in healthy subjects, single doses of sitagliptin up to 800 mg were well tolerated. In the 800 mg sitagliptin dose study, there was little increase in QT interval and no clinical effect. At present, there is no experience with doses higher than 800 mg in adults. Therefore, if the patient overdoses, it is advisable to apply supportive measures such as induction of vomiting, gastric lavage, clinical monitoring (including electrocardiogram) and supportive treatment, if necessary.

4. Side effects of the drug Zlatko 100


When taking Zlatko 100 may cause some side effects including:
Common undesirable effects: Headache, diarrhea, abdominal pain, slow digestion, nausea and vomiting, upper respiratory tract infection , nasopharyngitis, angioedema, fungal dermatitis, hypoglycemia. Severe, potentially fatal side effects such as: anaphylaxis, severe skin reactions such as Stevens-Johnson syndrome. Tell your doctor right away if you experience any unwanted effects while using this medicine.

Sử dụng Zlatko 100mg giúp hạ đường huyết trong điều trị đái tháo đường
Sử dụng Zlatko 100mg giúp hạ đường huyết trong điều trị đái tháo đường

5. Notes when using Zlatko 100


This is a drug prescribed by a doctor, so do not self-medicate. Patients should use as directed and need to inform the doctor if you are allergic to any of the ingredients in the medicine. Hypoglycaemia when Zlatko is used in combination with a sulfonamide hypoglycaemic: The reported incidence of sulphonamide-induced hypoglycaemia was higher in the sitagliptin plus sulphonamide (SU) group. Therefore, to reduce the risk of hypoglycemia due to SU, a reduction in the dose of SU may be considered. Hypersensitivity Reactions: There have been reports of serious hypersensitivity reactions in patients receiving sitagliptin. These hypersensitivity reactions include anaphylaxis, angioedema, exfoliative skin diseases including Stevens-Johnson syndrome. These reactions usually begin to appear during the first 3 months after starting treatment with sitagliptin, with some reports occurring after the first dose. If you suspect a hypersensitivity reaction, seek medical attention immediately. During treatment, do not arbitrarily adjust the dose or quit the drug. You need to combine with a scientific and moderate diet, reduce sugar, reduce starch and increase regular exercise to control blood sugar levels well. Pregnancy: As with other antidiabetic drugs, this drug is not indicated for use during pregnancy. Breastfeeding women should also not use it, because its effectiveness and safety are unknown. Drug Interactions: Drug interactions can occur that may alter the effects of therapeutic drugs, increase toxicity or increase the risk of side effects. Some drugs that can cause side effects include:
Alcohol, anabolic steroids, MAO inhibitors (MAOIs), testosterone can increase the degree of hypoglycemia of sitagliptin, the risk of hypoglycemia when taking the drug. . Sitagliptin increases the plasma concentration of digoxin, increasing the risk of digoxin toxicity. When used with beta-adrenergic blockers there is a risk of masking the hypoglycaemic markers of antidiabetic agents. . Drugs such as Ketoconazole, Itraconazole, Ritonavir, Clarithromycin may alter the effect of Sitagliptin in patients with severe renal impairment or end-stage renal failure requiring hemodialysis/peritoneal dialysis. However, the actual effectiveness in clinical practice has yet to be evaluated. Store the medicine in a cool, dry place and out of the reach of children. Do not use the medicine if it has expired or shows signs of deterioration.
Above is some information about the drug Zlatko 100. This is a new antidiabetic drug, with a new mechanism of action, so it can limit some of the side effects of the old drug. However, if you intend to change or use this medicine, you should consult with your doctor.
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