This is an automatically translated article.
Xiaflex medicine has the main active ingredient is the enzyme Collagenase extracted from the bacterium Clostridium Histolyticum. So what does Xiaflex do?
1. What are the effects of Xiaflex?
Xiaflex has the main active ingredient Collagenase clostridium histolyticum. This active ingredient is essentially an enzyme (called collagenase) extracted from the bacterium Clostridium histolyticum. The enzyme Collagenase breaks down the collagen that makes up connective tissue and scar tissue.
Xiaflex is indicated for the treatment of the following conditions:
Peyronie's disease; Dupuytren's spasticity. Xiaflex medicine is manufactured in powder form in a single-use vial. The treating doctor uses powder to create Xiaflex solution for injection. For Dupuytren spasticity, Xiaflex is injected into the fibrous band in the palm of the hand while for Peyronie's patients, Xiaflex is injected into the plaque on the penis.
2. Some warnings before taking Xiaflex
Before being treated with Xiaflex, please tell your treating doctor if you have bleeding or clotting disorders.
Xiaflex may damage nerves, tendons or ligaments in the hand where the medicine is injected. After the Xiaflex injection site has reduced swelling, the patient should contact their doctor if hand numbness, tingling, increased pain, difficulty flexing the finger toward the wrist, or new or severe abnormal movements appear. than in the hand. Xiaflex can also damage the tissues responsible for penile erection in men, sometimes requiring surgery to correct. Therefore, patients should contact their doctor immediately if the penis is bruised and swollen, pain when urinating, blood in the urine, sudden erection problems.
Patients should not use Xiaflex if there is a background or history of allergy to Collagenase clostridium histolyticum. Also Xiaflex should not be used to treat Peyronie's disease affecting the urethra.
To ensure the safety of treatment with Xiaflex, patients should inform their doctor if they have the following problems:
Bleeding disorders or blood clotting disorders; Are taking blood thinners such as Warfarin. FDA classifies Xiaflex pregnancy effects as Category B. Although unlikely to cause harm to an unborn baby, patients should tell their doctor if they are pregnant or plan to become pregnant during treatment with Xiaflex. Xiaflex .
It is not known whether Collagenase clostridium histolyticum is excreted in human milk or, if so, whether it will harm a nursing infant. Therefore, tell your doctor if you are breast-feeding while using Xiaflex.
3. Instructions for using Xiaflex
For Dupuytren's spasticity:
The doctor will inject Xiaflex directly into the fibrous band on the hand, causing the patient's finger to curl inward. The recommended dose for 1 injection is 0.58mg of Xiaflex; Patients can receive up to 2 injections in the same treatment. If there is a fibrous band causing 2 joints in the same finger to bend, the doctor may inject 2 Xiaflex injections at different places on the fibrous band or if 2 fibrous bands affect 2 separate fingers. curvature, the doctor may inject 1 injection into each fibrous band. Typically, patients see their doctor 1 to 3 days after their Xiaflex injections. If the fibrous band has not broken, the doctor can slowly straighten the finger to assist in breaking the fibrous band. This is usually done after the patient has been injected with a local anesthetic; If the patient's finger still cannot straighten, the doctor can inject Xiaflex again after 4 weeks, after 1 to 3 days the doctor will try to straighten the patient's finger again. Each fibrous band can be treated up to 3 times over a 4-week period. For Peyronie's disease:
The doctor will inject Xiaflex directly into the plaque (fibrous scar tissue) on the penis that causes it to warp. Patients may receive up to 4 cycles of treatment approximately 6 weeks apart; For each treatment cycle, patients will receive 2 injections of Xiaflex 1 to 3 days apart. The recommended dose for each injection is 0.58mg of Xiaflex. After 1 to 3 days from the 2nd injection, the patient will have a follow-up visit so that the doctor can try to stretch the plaque manually and help straighten the penis; If the angle of the penile curve drops below 15 degrees after any treatment cycle, the patient will not need any more treatment cycles; Besides Xiaflex injection, the patient should perform gentle exercises to lengthen and straighten the penis at home daily for a period of 6 weeks; Note that the patient should not have any sexual activity for at least 2 weeks after the second injection of Xiaflex if the first injection causes pain or swelling in the penis. Things to avoid before and after Xiaflex injection :
After Xiaflex injection to treat Dupuytren spasticity, the patient should not flex or extend the fingers of the treated hand until their next doctor visit head. Extending the finger can cause the medicine to spread beyond the treatment area and reduce its effectiveness. Avoid strenuous activities that require the use of the injected hand until authorized by your doctor; Avoid sexual activity during treatment for Peyronie's disease. The doctor will let the patient know when it is safe to have sex.
4. Side effects of Xiaflex
Patients should seek emergency treatment if there are any signs of an allergic reaction to Xiaflex such as rash, chest pain, difficulty breathing, feeling of impending fainting, swelling of the face, lips, tongue or throat.
Xiaflex may damage nerves, tendons or ligaments in the injected hand. After the Xiaflex injection site has reduced swelling, the patient should call the doctor if the following signs are present:
Numbness, tingling; Increased pain; Difficulty bending fingers toward the wrist; New or worsening abnormal movement in the injection hand. Xiaflex can damage the tissues responsible for penile erection and sometimes requires surgery to correct. Patients should contact the treating doctor immediately if the following symptoms occur:
Penile bruising and swelling; Pain when urinating, bloody urine; Sudden penile erection; Contact the treating doctor immediately if the patient has the following side effects of Xiaflex:
Manifestations of infection such as fever, chills, rash or swelling; severe pain, itching, or irritation; Feeling about to faint (even while lying down). Some other common side effects of Xiaflex include:
Swelling, bruising, bleeding or pain at the Xiaflex injection site; Swollen lymph nodes in the elbow or armpit; itchy, red, or hot skin; Stretch; Pain under the arm; Pain in the treated hand; Bruising of the penis or scrotum, erection problems; Penis skin discoloration, bruising or blistering where Xiaflex was injected.
5. Xiaflex drug interactions
Before treatment with Xiaflex, patients should talk to their doctor and pharmacist about a list of all prescription, nonprescription and other medications they are taking (including vitamins, herbs and supplements) supplement).
Drugs that may interact with Xiaflex include anticoagulants or blood thinners. This interaction increases the risk of bleeding and bruising when Xiaflex is injected. Such drugs include:
Apixaban (Eliquis); Dabigatran (Pradaxa); Dalteparin (Fragmin); Edoxaban (Savaysa); Enoxaparin (Lovenox); Fondaparinux (Arixtra); Rivaroxaban (Xarelto); Warfarin (Jantoven). Above is important information about Xiaflex medicine. Before using, patients should carefully read the instructions for use and consult a professional doctor to get the best treatment results.
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