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Drug X Plended tablet 10mg is a drug belonging to the group of drugs that lower blood lipids of the statin group. X Plused tablet 10mg is commonly used in clinical practice with a dose of 1 tablet / day. So what are the ingredients of XPlended tablet 10mg?
1. What is XPlended tablet 10mg?
Composition Each film-coated tablet XPlended tablet 10mg contains: Rosuvastatin 10 mg, as Rosuvastatin calcium. Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, a rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, a cholesterol precursor. The main site of action of Rosuvastatin is the liver, which is the target organ for lowering cholesterol. Rosuvastatin acts to increase the number of hepatic LDL receptors on the cell surface, leading to increased endocytosis and catabolism of LDL, inhibiting VLDL synthesis.Rosuvastatin reduces elevated levels of LDL-cholesterol, total cholesterol, triglycerides and increases HDL-C levels. Rosuvastatin also decreased concentrations of apoB, non-HDL-C, VLDL-C, VLDL-TG and increased apoA-I.
2. What are the uses of XPlended tablet 10mg?
Indications for use of X Plended tablet 10mg in the following medical conditions:
As an adjunct to the diet to reduce elevated levels of total cholesterol, (LDL-C), apoB, non-HDL- C and triglyceride levels and elevated HDL-C levels in patients with primary hypercholesterolemia (heterozygous with/without familial) and readily treatable mixed dyslipidemia (Fredrickson types Ia and IIb) ). Adjunct to nutrition for the treatment of patients with elevated serum triglyceride levels (Fredrickson type IV). Lowers LDL-C, total cholesterol and apoB in patients with homozygous familial hypercholesterolemia.
3. Dosage and how to use X Plended tablet 10mg
Drug XPlended tablet 10mg is formulated as a film-coated tablet that should be used orally.
Initiate Rosuvastatin 5 or 10 mg, once daily orally. If necessary, the dose of Rosuvastatin can be adjusted every 4 weeks. The dose of Rosuvastatin 40 mg should only be used when severe hypercholesterolemia at high risk of cardiovascular disease is not achieved with the dose of Rosuvastatin 20 mg, at which time the patient should be monitored regularly.
4. Contraindications of X Planted Tablet 10mg
Contraindications of X Plended tablet 10mg in the following cases:
X Plended tablet 10mg is contraindicated in patients with hypersensitivity to the components of this preparation. Rosuvastatin should not be used in patients with active liver disease or long-term elevations in serum transaminases. Rosuvastatin should only be used in women of childbearing age when it is clear that they are not pregnant and have been thoroughly informed about the potential risk of XPlended tablet 10mg. If a female patient becomes pregnant during treatment, the drug should be discontinued immediately and the patient informed of the potential risk to the fetus. Contraindicated to use X Planted tablet 10mg for women who are pregnant or will become pregnant.
5. Warning when taking X Planted tablet 10mg
Warning when taking X Plended tablet 10mg in the following cases:
It is recommended to do liver enzyme tests before starting treatment with X Plended tablet 10mg Use with caution X Plended tablet 10mg for patients taking a lot alcohol/alcoholic or previous history of liver disease; Use with caution X Plended tablet 10mg for people who have predisposing factors for muscle disease such as liver failure, kidney failure. Patients should be advised to promptly report unexplained muscle pain, muscle tension or weakness, especially when accompanied by malaise or fever. Before taking XPlended tablet 10mg, a CK test should be done in the following cases: impaired renal function, hypothyroidism, personal or family history of hereditary myopathy, statin-associated myopathy or previous fibrates, history of liver disease and/or alcohol consumption, elderly patients (>70 years) at risk for rhabdomyolysis, and certain patient populations, especially patients with hypothyroidism uncontrolled, kidney disease. In these cases, the benefit/risk balance and clinical monitoring of statin therapy should be considered. If CK test results are >5 times the upper limit of normal, statin therapy should not be initiated. During the course of treatment with X-Plended tablet 10mg, patients need to report when there are muscle symptoms such as muscle pain, muscle stiffness, muscle weakness..., when these symptoms are present, the patient needs to be tested. CK testing for appropriate interventions. It is necessary to closely monitor for adverse reactions during the use of XPlended tablet 10mg. Rosuvastatin should be discontinued when creatinine-kinase levels are too high or when myopathy is diagnosed or suspected.
6. Side effects of the drug X Planted tablet 10mg
Adverse reactions to XPlended tablet 10mg are usually mild and transient. In clinical studies, 3.7% of patients discontinued due to adverse events associated with Rosuvastatin. The most common adverse events associated with XPlended tablet 10mg were myalgia, constipation, asthenia, abdominal pain and nausea. Other possible side effects of XPlended tablet 10mg include:
Body as a whole: abdominal pain, chest pain, infection, neck pain; Cardiovascular: hypertension, angina pectoris, palpitations; Digestive system: constipation, vomiting, belching, abscess around the teeth, gastritis; Endocrine: increases the risk of diabetes; Metabolic and nutritional disorders leading to peripheral edema; Musculoskeletal system: arthritis, arthralgia. pathological fractures; Nervous system: dizziness, somnolence, hypertonia, paresthesia, depression, anxiety, dizziness, neuropathic pain; Respiratory system: bronchitis, increased cough, shortness of breath, pneumonia; Rash, itching.
7. Drug interactions of X Planted tablet 10mg
Some possible drug interactions X Plended tablet 10mg are as follows:
Cyclosporin: When Rosuvastatin was combined with cyclosporin in heart transplant recipients, the mean increase in Rosuvastatin Cmax was 11 times and the AUC increased by a mean of 7 times. compared with the combination of these two drugs in healthy volunteers. This increase in pharmacokinetics requires consideration of the dosage of Rosuvastatin for patients receiving cyclosporin; Warfarin: Co-administration with Rosuvastatin in patients on stable warfarin resulted in an increase in INR (> 4; baseline 2 - 3); For patients co-administering coumarin anticoagulants with rosuvastatin, the INIR should be determined prior to initiating rosuvastatin. Gemfibrozil: Co-administration of a single dose of rosuvastatin to healthy volunteers receiving gemfibrozil (600 mg twice daily) will affect the pharmacokinetics of rosuvastatin. XPlended tablet 10mg is a drug belonging to the group of drugs that lower blood lipids of the statin group. X Plused tablet 10mg is commonly used in clinical practice with a dose of 1 tablet per day. To ensure effective use and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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