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Viacoram 3.5mg / 2.5mg content has the main active ingredients Perindopril and Amlodipine besilate. Viacoram is used to treat high blood pressure.
1. What is Viacoram?
Viacoram is a drug used to treat heart disease. About the packaging is a box of 1 vial, each bottle contains 30 tablets. The dosage form of Viacoram is a tablet. Each tablet contains active ingredient Perindopril 2,378mg corresponding to Perindopril arginine content 3.5mg, active ingredient Amlodipine besilate 3,4675mg corresponding to Amlodipine 2.5mg.
Effects of active ingredients:
Perindopril: Is an inhibitor of the enzyme converting Angiotensin I into Angiotensin II leading to vasodilating effects and lowering blood pressure. Amlodipine: Inhibits the influx of calcium ions belonging to the Dihydropyridine group. This is a class of drugs with slow channel blocking or calcium ion antagonism. Therefore, this active substance inhibits the flow of calcium ions through smooth muscle of blood vessel walls and membranes into cardiac muscle cells. Two antihypertensive agents by 2 different mechanisms enhance the antihypertensive effect.
2. What disease does Viacoram treat?
Viacoram 3.5mg/2.5mg is used in the treatment of essential hypertension in adults.
3. Usage and dosage of Viacoram
3.1. How to use the drug: Viacoram is made in the form of tablets, suitable for oral use. Take Viacoram with a glass of water equivalent to about 250-350 ml. 3.2. Therapeutic dose of the drug: Start treatment with a dose of 1 Viacoram tablet 3.5mg/2.5mg x 1 time/day. This is the first dose of treatment immediately after the discovery of arterial hypertension. After at least 4 weeks, the doctor may increase the dose to 7mg/5mg once a day if blood pressure is still not adequately controlled with Viacoram 3.5mg/2.5mg tablets. For people with kidney failure:
In average, the drug should be used every other day. If your blood pressure is not adequately controlled, your doctor will prescribe medication every day.
4. In case of over/missing dose of Viacoram
In case of Viacoram overdose:
Overdose symptoms: Severe overdose can lead to excessive peripheral vasodilation and reflex tachycardia. Systemic hypotension is quite pronounced and can persist for a long time leading to shock and even death. The management of this case is cardiovascular support including regular monitoring of heart and respiratory function, edema of the extremities and extra attention to circulating volume and urine output when blood pressure is markedly elevated. . Your doctor may prescribe gastric lavage to reduce the amount of Viacoram absorbed. In addition, doctors can also take timely emergency measures to best minimize complications from overdose. If you miss a dose of Viacoram: You should try to take it as soon as you remember that you have missed a dose. However, if the missed dose is close to the next dose, skip the missed dose and follow the dosing schedule. Note that, absolutely do not use the drug with a double dose to make up for the forgotten dose.
5. Undesirable effects of Viacoram
During the treatment of hypertension with Viacoram, you may experience some unwanted effects, including:
Appears dizziness; Coughing; Peripheral edema; Increased potassium in the blood; Increased blood sugar levels; There are other signs such as erythema multiforme, fatigue.
6. Interactions of Viacoram
Drug interactions to note when using Viacoram, including:
Aliskiren: High risk of adverse events such as hypotension, increased blood potassium and impaired kidney function. Therefore, these two drugs are not recommended to be used concurrently. Estramutine: When Viacoram is used with this drug, it increases the side effects of peripheral angioedema. Potassium-sparing diuretics such as Triamteren, Amiloride) and Potassium (salt forms): Increased potassium in the blood, severe cases can lead to death. Drugs that cause hyperkalemia: Concomitant use of this group of drugs with Viacoram increases the risk of hyperkalemia. Lithium: Reversible increase in serum lithium concentration and toxicity. Caution when used concurrently with Viacoram:
Antihypertensives such as beta-blockers and vasodilators: Increases the hypotensive effect of Viacoram, which can cause serious blood pressure damage. . Gliptins, specifically Linagliptin, Saxagliptin, Sitagliptin, Villagliptin: When used concurrently, increases the risk of angioedema. Tricyclic antidepressants, antipsychotics, anesthetics: When used together with Viacoram, there is an increased possibility of lowering blood pressure. Corticosteroids, Tetracosactide: Decreased antihypertensive effect is due to the effect of water and salt retention of Corticosteroids. Alpha blockers, such as Alfuzosin, Doxazosin, Tamsulosin, Prazosin, Terazosin: When used together with Viacoram, it increases the antihypertensive effect and increases the risk of orthostatic hypotension. Amifostin: When used together with Viacoram, the antihypertensive effect of Amlodipine is increased. Grapefruit juice: Increases bioavailability of the active ingredient Amlodipine, increases the antihypertensive effect of Viacoram. The above are not all drug interactions that can be encountered when using Viacoram. To ensure safety and effectiveness, you need to proactively inform your treating doctor about all medicines, health foods that you are using and other diseases you are having.
7. Some notes when using Viacoram
7.1. Contraindications of the drug: People with hypersensitivity or hypersensitivity to the active ingredient, angiotensin-converting enzyme inhibitors, dihydropyridine derivatives or any of the excipients. People with severe kidney disease. Patients with a history of angioedema related to previous treatment with ACE inhibitors. People with hereditary angioedema or idiopathic angioedema. Women who are pregnant during the second and third trimesters of pregnancy. People with severe hypotension. People in shock, including cardiogenic shock. People with left ventricular outflow tract obstruction, specifically severe aortic stenosis). Patients with heart failure who are hemodynamically unstable after acute myocardial infarction. Concomitant use with Aliskiren with diabetes or renal failure with glomerular filtration rate < 60 ml/min/1.73 m2. People with significant bilateral renal artery stenosis or narrowing of the artery in one kidney assumes the other function. 7.2. Precautions for use: Use with caution in people with a history of angioedema in the past.
Be careful when using Viacoram for patients with heart failure, mitral stenosis, aortic stenosis, hypotension, hypertrophic cardiomyopathy; people with diabetes. In case people suffer from collagen vascular disease, are being treated for immunosuppression, they must be very careful when taking Viacoram. Before surgery or anesthesia: Stop using the drug 1 day before the procedure. Your doctor will order to monitor potassium levels in the blood. 7.3. Using drugs with special subjects For pregnant women:
Viacoram is not recommended during the first 3 months of pregnancy. Contraindicated to use the active ingredient Perindopril (in the composition of Viacoram) in the second and third trimesters of pregnancy. The use of ACE inhibitors during the second and third trimesters of pregnancy is known to cause fetal toxicity and high toxicity to the neonate such as renal failure, hypotension,... Infants born to mothers receiving Viacoram should be closely monitored for hypotension.
For lactating women
With the active ingredient Perindopril: There is no information regarding the use of the drug during lactation. Therefore, the use of this drug is not recommended and should be replaced with another safer drug during lactation, especially for infants or premature babies.
8. How to store Viacoram?
Keep Viacoram out of reach of children and pets.
Store Viacoram in a cool, dry place. Avoid exposure to direct sunlight or store the medication in humid areas.
The best storage temperature for Viacoram is from 15-30oC.
Information about the expiration date of the drug is fully presented on the product packaging. Therefore, you need to carefully check the information and should not use it if the medicine has expired.
Hopefully with the sharing of Viacoram drug will help the process of using it effectively, bringing positive effects in the treatment of diseases.
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