This is an automatically translated article.
Smabelol medicine contains the ingredient Nebivolol 5mg which is made in tablet form. The drug belongs to the group of cardiovascular drugs and is used to treat idiopathic hypertension, stable heart failure.... However, Smabelol can cause some unwanted side effects such as headache, flowers eyes, paresthesia... Therefore, before using the drug, the patient needs to learn carefully the information and follow the doctor's instructions.
1. Mechanism of action of the drug Smabelol
Smabelol 5mg contains the active ingredient Nebivolol which belongs to a racemic mixture of two isomers and has a combination of both pharmacological actions: a selective beta-receptor blocker and mild vasodilating properties due to interaction with L-arginine on the way of the drug when entering the body.Both isomers of Smabelol can be rapidly absorbed after oral administration. This absorption is not affected by food, so the drug can be used regardless of the meal.
After taking Smabelol for one week, about 38% of the dose is excreted in the urine and 48% in the feces.
2. Indications and contraindications to the use of Smabelol
Smabelol is indicated in the treatment of hypertension or primary hypertension. In addition, Smabelol is also indicated for the treatment of chronic heart failure.
However, Smabelol may be contraindicated to use Smabelol in the following cases:
Liver failure and impaired liver function Acute heart failure, cardiogenic shock, or episodes of heart failure decompensated and requiring intravenous inotropic heart muscle squeeze. The patient has a syndrome of conduction disturbances in the sinus node including atrial fibrillation. People with a history of bronchospasm or bronchial asthma
3. Dosage and how to use Smabelol
Smabelol drug is used for the following subjects:
For adults, use Smabelol at a dose of 5mg/day and should be taken at the same time of day. The drug works to lower blood pressure after 1 to 2 weeks of treatment. Sometimes, in some cases, the optimal effect can only be achieved after 4 weeks of use. Smabelol is combined with other antihypertensive drugs such as beta blockers to increase the effectiveness of blood pressure treatment. For patients with impaired renal function, the starting dose of Smabelol should be 2.5 mg. And if needed later, the dose can be increased to 5m/day. For patients with impaired liver function, currently, there are limited data on the use of Smabelol, so Smabelol should not be used to treat these cases. For the elderly and especially those over 65 years of age, the starting dose may be 2.5 mg/day and if necessary increase the dose to 5 mg/day. However, with limited experience in using the drug in patients over 75 years old, special attention should be paid to monitoring these subjects if Smabelol is indicated. For chronic heart failure, treatment can be initiated at 1 to 2 weeks at a dose of 1.25 mg and increased to 2.5 mg at a frequency of once daily and then increased to 5 mg once daily and finally 10mg/time/day. For patients with impaired renal function, no dose adjustment is required when the condition is mild to moderate. It should be noted: The above recommended therapeutic doses for Smabelol are for reference only. Therefore, before using Smabelol, patients need to be prescribed by a doctor.
If the patient has missed a dose of Smabelol, the missed dose can be used as soon as he remembers. However, if the interval between the missed dose of Smabelol and the next dose is close, the patient can skip the missed dose and take the next dose. Patients should also note that it is not recommended to use twice the dose of Smabelol, because it may cause an overdose of the drug and unwanted side effects that affect the patient's current health.
In case the patient accidentally takes an overdose of Smabelol than prescribed and has some signs of unwanted side effects, it is necessary to take the patient to the nearest medical facility to receive emergency treatment. timely medical support, helping patients overcome dangerous situations.
4. Unwanted side effects and some notes when using Smabelol
Smabelol can cause some unwanted side effects and has been reported separately from cases of high blood pressure and chronic heart failure. Because with both diseases, there are comorbidities.
For high blood pressure: may experience side effects of Smabelol such as:
Headache, dizziness, paresthesias Shortness of breath Constipation, nausea, diarrhea Fatigue, edema Nightmares, depression Decrease vision Arrhythmia with heart failure, bradycardia. slow atrioventricular conduction Slow bronchospasm Psoriasis may progress to more severe chronic heart failure may experience side effects when using Smabelol:
Slow heart rate, dizziness Low blood pressure stand Drug intolerance Lower extremity edema... Some notes on drug interactions:
For pharmacodynamic interactions of Smabelol: Smabelol should not be combined with beta-blockers such as: antiarrhythmic drugs Group 1, calcium channel blockers, antihypertensive drugs... For the pharmacokinetic interaction of Smabelol: because the metabolic mechanism of Smabelol involves isoenzyme CYP2D6, it should be used concurrently with inhibitors of the enzyme may increase plasma concentrations associated with an increased risk of excessive bradycardia and adverse systemic effects. Hopefully, the above sharing will help the process of using Smabelol to be highly effective and safe for the treatment process. If you have any questions, you should talk to your doctor for appropriate indications.
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