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Trimalact drug used in the treatment of malaria, with the main ingredients being Artesunate 100mg and Amodiaquine 300mg. The drug is prepared in the form of three-layer long tablets. For more detailed information about Trimalact, users can refer to the article below.
1. Uses and mechanism of Trimalact
Active ingredient Amodiaquine is a derivative of 4-aminoquinolein, which kills schizophrenia in erythrocytes of all 4 strains of Plasmodium falciparum, and also works against chloroquine-sensitive Plasmodium falciparum strains and some other strains. chloroquine resistance.
The mechanism of antimalarial action of amodiaquine is unknown but may be due to amodiaquine concentration, in the lysosomes of the malaria parasite, and loss of lysosome function. The drug Trimalact affects the digestion of hemoglobin and reduces the energy supply to the parasite.
Active ingredient Artesunate has the main effect of killing schizophrenia of P. falciparum in the blood, Trimalact against malaria is mainly due to the presence of endoperoxide bridge in the structural formula. This active substance adheres tightly to the red blood cell membrane containing the malaria parasite and reacts with the hematin in the parasite. At the same time, Artesunate also inhibits the production of oxidizing enzymes in erythrocytes or inhibits the activity of these enzymes that degrade the red blood cell membrane due to highly active oxidant radicals.
Trimalact is rapidly absorbed from the gastrointestinal tract, metabolized in the liver.
2. Indications to use Trimalact
Trimalact is indicated for use in:
Malaria caused by all types of Plasmodium Severe malaria Cerebral malaria Where the patient is resistant to other antimalarial drugs.
3. Contraindications to the use of Trimalact
The patient is allergic to amodiaquine, artesunate, or artemisinin derivatives contained in Trimalact or other excipients. Patient has liver disease. Women in the first trimester of pregnancy.
4. Notes when using Trimalact
Because Trimalact contains the active ingredient amodiaquine, it should not be used to prevent malaria caused by Plasmodium falciparum, which may cause some side effects on liver, or hematology: agranulocytosis.
When the patient takes a dose of trimalact greater than the recommended dose, it may cause neurological disorders such as unconsciousness, spasms, convulsions, movement disorders. Therefore, it is necessary to strictly follow the instructions of the specialist, avoid overdose or arbitrarily change the dose of medicine without examination.
In addition, the Amodiaquine component can cause blood disorders: hemolytic anemia, liver, peripheral nervous system. With prolonged dosing, regular eye examinations are necessary.
5. Trimalact drug interactions
Other antimalarial drugs when combined with Trimalact will increase the rate of agranulocytosis.
Chloroquine concurrent use of Trimalact may cause movement disorders.
Magnesium trisilicate and kaolin may reduce the absorption of Trimalact from the gastrointestinal tract when used in combination.
6. Notes when using Trimalact
There are currently insufficient data to support the safety of Trimalact during pregnancy. Therefore, it is necessary to consider before using Trimalact combination for pregnant women, especially note that Trimalact should not be used for pregnant women in the first 3 months.
For women who are breast-feeding, because studies in this sensitive population have not been adequate, breast-feeding should be discontinued during treatment with trimalact.
7. Dosage and how to use Trimalact
Children from 1 to 6 years old: Take 1/2 tablet/time/day, dose for 3 days. Children from 7 to 13 years old: Take 1 tablet/time/day, dose for 3 days. Children over 13 years old and adults: 02 tablets/time/day, dose for 3 days.
8. Trimalact side effects
The drug trimalact can cause some side effects such as:
Hematologic disorders Liver function disorders Peripheral neuropathy Digestive disorders: nausea, vomiting, diarrhea Skin: rash , allergies Headache, dizziness, dizziness Visual disturbances The above side effects may not have been listed, so if you experience any unusual signs during the use of trimalact, please notify us immediately. doctor.
9. Trimalact drug overdose
When using an overdose of Trimalact you may experience signs: unconsciousness, drowsiness, spasticity, convulsions, loss of coordination, headache, dizziness, nausea. More severe manifestations: cardiovascular disorders, convulsions, coma, hypotension, shortness of breath, cardiac arrest, hypokalemia, especially visual disturbances, vision loss can lead to blindness.
When there are symptoms of an overdose of Trimalact, it is necessary to induce vomiting immediately or wash the stomach as soon as possible, before taking to the hospital.
Activated charcoal can be used as soon as possible to limit drug absorption, the amount of activated charcoal needed is 5 times the amount of amodiaquine used. At the same time, take the patient to the nearest medical facility for examination.
Patients need to be closely monitored for at least 6 hours even after the crisis is over.
In short, Trimalact drug is a drug to treat malaria, which should be consulted, examined and prescribed by a doctor. Avoid self-medicating without being examined to limit side effects and adverse interactions.
