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Eurartesim 160/20 contains the main ingredient Piperaquine tetraphosphate (a bisquinoline) with a concentration of 160mg and Dihydroartemisinin at a concentration of 20mg. It is used to treat most forms of malaria, even those that are resistant to other antimalarial drugs. The drug is highly effective and safe to use.
1. What is Eurartesim 160/20?
Eurartesim 160/20 is a brand name combination of Piperaquine tetraphosphate and Dihyroartemisinin in the same formula, used only when prescribed by a doctor. The drug is a product of Sigma-Tau Industrie Farmaceutiche Riunite S.P.A Via Pontina Km 30, 400-00040 Pomezia (RM) Italy and is prepared in the form of film-coated tablets (box of 1 blister, 3 tablets per blister).
Each Eurartesim 160/20 tablet contains 160mg of Piperaquine tetraphosphate (as tetrahydrate) and 20mg of Dihydroartemisinin. In addition, it also contains a number of other excipients, including: Tablets (pre-gelatinized starch, dextrin, hypromellose (E464)), eroscarmellose sodium, magnesium stearate (E572) and film coating (hypromellose, titanium dioxide (E572). E171), macrogol 400).
2. What are the uses of Eurartesim 160/20?
The drug is used for the main purpose of treating malaria.
DHA can reach high concentrations in parasitized red blood cells. The peroxide bridging in the DHA molecule is required for antimalarial activity, causing free radical damage on the cell membrane of the parasite. Piperaquine has a strong inhibitory effect on chloroquine-resistant strains of Plasmodium malaria. Furthermore, it kills their spores and reduces malaria transmission.
After oral administration, DHA is rapidly absorbed, reaching peak plasma concentrations within 1 hour. The half-life of Piperaquine is about 22 days for adults and about 20 days for children.
The drug does not affect the ability to drive or use machines.
3. Instructions for using Eurartesim 160/20
Eurartesim 160/20 is indicated in the treatment of most types of malaria caused by Plasmodium falciparium, Plasmodium vivax, Plasmodium oval, Plasmodium malaria, including strains resistant to other antimalarial drugs.
The drug can be used for both adults, children and children over 6 months of age weighing 5 kg or more.
Take the medicine with water, on an empty stomach, at least 3 hours after eating and do not eat within 3 hours after taking the medicine. If it is difficult to swallow, it can be crushed and mixed with water, then drink the mixture immediately.
Treatment regimen Eurartesim 160/20 lasts 3 consecutive days, administered once daily, should try to take the drug at the same time each day.
Dosage depends on the patient's weight:
Patients from 5 to under 7kg: Half a 160mg/20mg tablet per day. The total number of tablets for the treatment regimen is 1.5 tablets. Patients 7 to 13 kg: One 160mg/20mg tablet daily. The total number of tablets for the treatment regimen is 3 tablets. For pregnant women: Eurartesim 160/20 should not be used in pregnant women if there are other drugs that can be substituted. If used, it is mandatory to terminate the pregnancy (termination of pregnancy). For breast-feeding women: Do not use the drug while breastfeeding. Before prescribing Eurartesim 160/20, tell your doctor if you or your loved one has one of the following contraindications:
Hypersensitivity to the active ingredients Piperaquin tetraphosphate, Dihydroartemisinin or to any of the ingredients in this medicine. medicine. Children under 6 months old or weighing less than 5kg. Severe malaria, which affects the brain, lungs and kidneys. Have a heart abnormality, such as an arrhythmia or other heart disease. In the family, there is a close relative who died suddenly from heart disease or had congenital heart disease. Electrolyte disturbances. Are taking drugs that affect heart rate, antidepressants, drugs for mental disorders, infections, antihistamines, drugs for cancer, HIV infection, angina, digestive disorders and blood lipids , addiction. Have been treated for malaria with another drug or have taken anti-malarial medicine within the last 1 month. These drugs include: Mefloquin, Halofantrin, Lumefantrin, Chloroquin or Quinine. In addition, caution should be exercised in patients with the following problems when using Eurartesim 160/20:
Have liver or kidney problems. Infection with other malaria parasites other than Plasmodium falciparum. Have taken or are taking any other medicines for malaria (not listed above). Women who are pregnant or breastfeeding. Women, the elderly (> 65 years old) or vomiting. Are taking other drugs that have the potential to cause interactions. If vomiting occurs after taking the drug within the first 30 minutes, repeat the entire dose as before, in case of 30 minutes, take half the original dose. If vomiting continues after taking the second dose, do not take any more doses. In this case, you should contact your treating doctor to change the treatment regimen.
A special case is that if the patient is infected with another malaria agent, the regimen of Eurartesim 160/20 can be reintroduced within one year after the consent of the physician. This regimen should not be used more than twice in a year, nor should it be used again within 2 months of its first use. If the patient is infected with malaria parasites more than 2 times in a year, the doctor should be consulted about alternative regimens.
When an overdose of the drug Eurartesim 160/20 requires hospitalization for a special monitoring regime because there will be serious toxicity on the heart. If you miss a dose, take it as soon as you remember, and take your next dose 24 hours later. Never take more than 1 dose in the same day.
Do not tear the drug packaging, store at a temperature below 30oC and in a dry place, avoid moisture as well as direct light on the product.
4. Eurartesim 160/20 drug interactions and side effects
4.1. Drug Interactions Some medications affect the mechanism of action of Eurartesim 160/20 and your doctor may decide not to take the drug or require further testing.
The list of drugs that are likely to interact when used with Eurartesim 160/20 is listed below:
Drugs to treat dyslipidemia. Medicines to treat high blood pressure and heart disease. HIV medication. Antibiotic. Sedative. Medicines to prevent or treat epilepsy. Drugs used after organ transplantation and in autoimmune diseases. Sex hormones, including birth control pills. Glucocorticoids. Medicines to treat digestive disorders. Pain reliever and anti-inflammatory. Asthma medication. Drugs to treat depression. Antiemetics. Some gases are used in anesthesia. In addition, do not take Eurartesim 160/20 with grapefruit juice because of possible drug interactions. For people who are taking iron pills to prevent congenital neural tube defects, they can still continue to take it at the same time as Eurartesim 160/20.
4.2. Side effects of Eurartesim 160/20 Eurartesim 160/20 can cause some side effects, but most are not serious and usually go away within a few days to a few weeks after treatment.
Possible side effects of Eurartesim 160/20 include:
Allergy to the drug. Heart rhythm disturbances. Cold, cough, fever. Infection. Blood cell abnormalities. Digestive disorders. Dermatitis, skin rash. Headache, dizziness, dizziness. The article has provided information on what Eurartesim 160/20 is, dosage and notes for use. To ensure safety for your health and maximize the effectiveness of your treatment, you need to take Eurartesim 160/20 exactly as directed by your doctor.
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