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Taxol is widely used in the market with the scientific name Paclitaxel. Taxol belongs to a group of drugs used to treat cancer, used in combination with other drugs that have the ability to affect the body's immune system, administered as an infusion.1. What is Taxol?
Taxol (Paclitaxel) is a chemotherapy drug used to treat breast cancer, lung cancer, ovarian cancer, cervical cancer, and pancreatic cancer. The drug is given into the body by injection into a vein. Taxol has the effect of preventing the division and multiplication of cancer cells, reducing the growth and spread of these cells.
2. Uses of the drug Taxol
Doctors often prescribe Taxol to be used in the treatment of breast cancer as follows:
Primary breast cancer: Taxol is used in combination with some other drugs to treat primary breast cancer (cancer) has not fully spread to the lymph nodes under the arm).
Before surgery: Taxol is indicated before surgery to reduce the size of large tumors. The patient will be prescribed Taxol as a breast cancer drug to reduce the process of replication and metastasis to other parts of the body. After surgery: Taxol is used to reduce the risk of cancer coming back. Metastatic breast cancer: Taxol is used in combination with doxorubicin to treat breast cancer that has spread to the tissues and lymph nodes around the neck, chest, and below the collarbone or other organs of the body.
In addition, the drug is also used in the treatment of lung cancer, AIDS-related Kaposi's cancer
3. Instructions for using the drug
Use a solvent to dilute the drug, including: 5% glucose solution, 0.9% sodium chloride solution, a mixture of 0.9% sodium chloride solution and 5% glucose solution or a 5% glucose solution mixture. and ringer's solution. Prepare the infusion as above within 27 hours at room temperature about 25 degrees C and under light. Administer the infusion immediately or within 3 hours after the preparation is complete. Do not store the reconstituted infusion in the refrigerator. For the most effective effect when administering drugs, when infusion should use a filter with a vial hole not larger than 0.22 micrometers on the infusion line. The drug is mixed for intravenous infusion. However, the mixologist needs to have experience, when mixing the drug, it is necessary to wear gloves, to avoid contact with the skin and mucous membranes. If skin is in contact, wash with soap and water. If the drug comes into contact with the mucosa, it should be rinsed thoroughly. To prevent some patients from having anaphylaxis, we also need to prepare Prednisolone: 30 - 40 mg (6 - 8 tablets, 5 mg/tablet), orally 12 hours and 6 hours before Taxol infusion.
4. Some unwanted side effects of drugs
Common side effects include:
Hair loss; Muscle pain; Diarrhea; Numbness in the limbs, allergies. Besides mild side effects, users may experience other more serious symptoms such as heart problems, increased risk of lung infections and lung disease.
5. Cases in which Taxol should not be used
Do not use for people who are hypersensitive to Taxol (Paclitaxel) Do not use the drug in patients with neutrophil counts < 1500/mm3 or with motor neuron disease. Do not use the drug for pregnant or lactating women. If a pregnant woman uses Taxol, it can cause birth defects in the fetus. In fact, several scientific studies have demonstrated that Taxol has been tested and found to be embryotoxic and fetotoxic in rabbits and to reduce fertility in rats. People with heart disease need to use it with caution and consult a doctor. Not recommended for use in children under 18 years of age. Because there are currently no scientific studies to prove the effectiveness and safety of the drug. Taxol is a prescription drug, so make sure you consult your doctor before using it. Hopefully, the article has provided you with useful information about the uses, dosage and precautions when using Taxol.
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Reference source: oncolink.org
