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Axitinib is a selective inhibitor of vascular endothelial growth factor (VEGFR) receptors. It is indicated in the treatment of renal cell cancer when other alternative therapies have failed. Let's learn about the uses and notes when using Axitinib through the article below.1. What is Axitinib?
Axitinib is made in tablet form under the brand name Inlyta, which is a selective inhibitor of vascular endothelial growth factor receptor (VEGFR). Axitinib helps stop the growth of cancer cells by inhibiting angiogenesis, stopping tumor growth. Specifically, the drug selectively blocks the Tyrosine kinase receptors VEGFR-1, VEGFR-2 and VEGFR-3.
Axinitib is indicated in the treatment of end-stage renal cell cancer when other alternative therapies are unsuccessful. failure. Currently, the drug is being researched and tested in the treatment of thyroid cancer, pancreatic cancer.
2. Dosage of the drug Axitinib
Axitinib belongs to the group of prescription drugs. Therefore, the dose of the drug is prescribed by the treating doctor. The recommended dose in the treatment of adult renal cell carcinoma is as follows:
Initial dose: Take 5mg/time x 2 times/day; Maintenance dose: The maintenance dose will be adjusted by the doctor depending on the safety and tolerability of the patient, varying in the range of 2 - 10mg / time x 2 times / day. The interval between doses is at least 12 hours.
3. Axitinib side effects
Axitinib can cause some side effects as follows:
Diarrhea, vomiting, nausea, constipation; Itching, rash, redness, and peeling of the skin on the hands or feet; Tired or feeling weak, losing strength; Hypertension ; Weight loss; Hoarseness. Patients need to stop using Axitinib and notify the treating doctor in case of experiencing the following reactions:
Allergic reactions: Difficulty breathing, hives, swelling of the face, lips, tongue or throat; Severe stomach pain or a feeling of choking or vomiting when eating or drinking. Because there have been cases of patients with gastric perforation when treated with Axitinib; Chest pain, pain spreading to the jaw or shoulder with difficulty breathing; Sudden numbness or weakness, vision or speech problems; headache, confusion, thinking problems, seizures; Easy bruising, unusual bleeding, purple red spots under the skin; Menstrual bleeding more than usual, pink urine; Feeling short of breath; Signs of stomach bleeding such as coughing up blood, vomiting, tarry stools; Thyroid signs, muscle pain, unusual heat or cold, hair loss, hoarse or deepening voice.
4. Notes when using the drug Axitinib
Contraindicated to use the drug in patients allergic to Axitinib.
Inform the treating doctor if the patient experiences the following symptoms:
Stomach ulcer; Bleeding or untreated wound healing; Heart failure, heart attack, stroke or blood clot; Hypertension; Liver disease; Thyroid disorders; Pregnant women. Both men and women being treated with Axitinib need to use birth control, because the drug can harm an unborn baby if the mother or father is being treated with Axitinib. The patient should continue to use birth control for at least 1 week after the last dose of the drug. In case the patient discovers that she is pregnant during treatment with Axitinib, it is necessary to inform the treating doctor.
For women who are breastfeeding, treatment with Axitinib is not safe for nursing infants.
5. Drug interactions
Axitinib can interact with some of the following drugs:
Deferasirox, Peginterferon alfa – 2b, Luliconazole increases the serum concentration of Axitinib; Teriflunomide, Dabrafenib reduce serum concentrations of Axitinib; Nelfinavir, Indinavir, Doxycycline, Clotrimazole, Terfenadine decrease the metabolism of Axitinib. Above are the uses, doses and notes when using Axitinib. To ensure the safety of your health and maximize the effectiveness of treatment, you need to take the medicine exactly as directed by your doctor.
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Reference source: drugs.com
