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The drug Rostat 10 has the main active ingredient Rosuvastatin and other excipients in sufficient quantities. Rostat 10 is indicated in the treatment of hypercholesterolemia. In addition, Rostat 10 is also effective for the prevention of cardiovascular events in people at high risk of a first cardiovascular event with an adjunct to the adjustment of other risk factors.
1. What is Rostat 10?
Rostat 10mg drug belongs to the group of drugs for the treatment of cardiovascular diseases. Rostat 10mg is available as a film-coated tablet. Packing is a large box of 10 pills, each box contains 1 blister, each blister contains 10 tablets. The main ingredient of the drug Rosat 10mg is the active ingredient Rosuvastatin in the form of Rosuvastatin calcium 10mg and other excipients in sufficient quantities. Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, an enzyme that catalyzes the conversion of 3-hydroxy-3-methylglutaryl coenzyme A to Mevalonate. precursors of cholesterol.
Absorption: Peak plasma concentrations of the active ingredient Rosuvastatin are reached approximately 5 hours after oral administration. The absolute bioavailability of Rostat 10mg is about 20%. Distribution: Active ingredient Rosuvastatin is widely distributed in the liver, the main site of cholesterol synthesis and clearance of LDL-C. The volume of distribution of the active substance Rosuvastatin is approximately 134 L. Approximately 90% of rosuvastatin is bound to plasma proteins, mainly to albumin. Metabolism: Rosuvastatin is rarely metabolised, only about 10% metabolized. Elimination: Approximately 90% of the therapeutic dose of the active ingredient Rosuvastatin is eliminated unchanged in the faeces, including absorbed and unabsorbed active substances. The rest is excreted in the urine.
2. What disease does Rostat 10mg treat?
Rostat 10mg drug is effective in the treatment of diseases, specifically as follows:
Treatment of primary hypercholesterolemia including heterozygous familial hypercholesterolaemia or mixed dyslipidemia. type llB). Treatment of homozygous familial hypercholesterolemia.
3. Usage and dosage of the drug Rostat 10
Initial treatment dose is 5 or 10 mg, once a day, if necessary, the dose can be adjusted every 4 weeks. The 40 mg dose should only be used when severe hypercholesterolemia is at high risk of cardiovascular disease and the therapeutic goal of 20 mg is not achieved. In addition, drug users need to be monitored regularly.
Note: For people with a history of liver disease, as with all statins, caution should be taken when used with people with predisposing factors for rhabdomyolysis such as those with renal insufficiency, hypothyroidism, personal history or family history of hereditary muscle disease, history of muscle toxicity caused by other HMG-CoA reductase inhibitors or fibrates, alcoholism, people over 70 years of age, conditions that cause elevated blood levels of the drug or used concurrently with Fibratem.
The treating doctor will advise to stop using Rostat 10mg, if CK > 5 x ULN or severe muscle symptoms. Rostat 10mg drug should not be used when there is sepsis, hypotension, people who have just undergone major surgery, people with trauma, electrolyte and endocrine disorders, severe metabolic disorders, such as convulsions. controllable.
If you have any further questions about the use of Rostat 10mg, the patient should directly discuss with the prescribing doctor for appropriate indications.
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