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Muxol 30mg is a mucolytic agent that acts on the gel phase of mucus by severing disulfur bridges of glycoproteins and thus facilitating expectoration. On the market today, there is a lot of information about Muxol drug products, but it is still incomplete. To better understand what Muxol is, what are the uses of Muxol, let's learn more in the article below.1. What is Muxol?
Muxol has Ambroxol as the main ingredient, which is a product of the pharmaceutical company Laboratoires Leurquin Mediolanum - France.
Muxol is prepared in many different forms such as:
30 mg tablets; Oral solution, 50 ml vial, 180 ml vial, 30 mg/5 ml Rarely produced : Injection 15 mg/2 ml and Nebulizer 15 mg/2 ml Oral solution form contains: Glycerol, 70% sorbitol (possibly crystallized), methyl parahydroxybenzoate, propyl parahydroxybenzoate, banana flavor (furfuryl acetate, isoamyl acetate, isobutyl acetate, methyl-3-butenyl acetate, acetoin, amyl butyrate, delta-decalactone, eugenol piperonal, benzyl propionate, maltol, vanillin, ), citric acid monohydrate, purified water.
The drug is prescribed by doctors in the following cases:
Digestion of respiratory mucus in acute and chronic diseases accompanied by abnormal increase in bronchial mucus secretion, especially in acute exacerbations of bronchial asthma. chronic bronchitis, asthmatic bronchitis. Prophylaxis and treatment of pulmonary complications in patients after surgery or with previous respiratory-related emergencies.
2. What are the uses of Muxol?
2.1 Pharmacodynamic properties of the drug Muxol 30mg Ambroxol belongs to a group of drugs that regulate the secretion of mucus and dissolve and eliminate sputum, this active ingredient acts on the gel phase of respiratory mucus by sever the disulfur connection of glycoproteins and facilitate evacuation by the cough reflex that pushes secretions out of the bronchi.
Bromhexin is converted to Ambroxol, so Ambroxol has the same effect and mechanism of action as Bromhexin. There is insufficient evidence that Ambroxol has expectorant and mucolytic effects.
Some literature reports that ambroxol improves symptoms in the acute phase and reduces the number of consecutive acute episodes in bronchitis. Recently, there are some documents that suggest that the drug has a good effect on patients with mild and moderate obstructive pulmonary disease, but has no obvious benefit in people with severe obstructive pulmonary disease. The aerosol dosage form of ambroxol also has a relatively good effect on patients with alveolar proteinosis who cannot tolerate or do not want to do bronchoalveolar lavage.
2.2 Pharmacodynamic properties of the drug Muxol 30mg Ambroxol is well absorbed from the gastrointestinal tract and reaches maximum plasma concentrations about 2 hours after oral administration. Bioavailability of the drug is about 70%. Drugs with a high volume of distribution demonstrate significant extravascular diffusion. The half-life of the drug is about 7.5 hours. The drug is mainly excreted in the urine with 2 major metabolites in the form of glucuronic conjugates. Elimination of the active substance and metabolites takes place mainly in the kidneys.
2.3 Contraindication of Muxol 30mg Patients who are allergic or have a history of allergy to any of the ingredients in Muxol Drugs Patients with advanced gastric and duodenal ulcers The syrup form should not be used by patients without tolerate certain sugars. Note before taking Muxol In case of cough with phlegm, it is necessary to let it naturally because it is the basic factor to protect the lungs-bronchi.
It is not reasonable to combine expectorants or expectorants with cough medicine.
Caution should be exercised in patients with peptic ulcer disease.
Pregnancy and lactation Animal studies have shown that the drug is not teratogenic. Due to the lack of data in humans, caution should be exercised to avoid this drug during pregnancy.
This medicine should not be used during breastfeeding. It is best to fully inform your doctor or pharmacist about your condition such as current medical condition, medical history, allergies, pregnancy, breastfeeding....
Need to read the instructions carefully before using the drug to avoid the harmful effects of the drug.
Precautions for taking Muxol while pregnant Before taking this medicine, always consult your doctor or pharmacist to weigh the benefits and risks of taking it while pregnant.
Look up the US Food and Drug Administration (FDA) classification of drugs for use in pregnancy below:
A = No risk;
B = No risk in some studies
C = Possible risk;
D = There is evidence of risk;
X = Contraindications;
N = Still unknown.
Note taking Muxol while breastfeeding Usually doctors still advise breastfeeding mothers not to take the medicine. Therefore, the mother will have to be very careful about taking the drug while breastfeeding. Carefully read the instructions for use the leaflets that come with the medicine box. Pay attention to the sections “Contraindications” and “Use during pregnancy or lactation”.
Notes on the use of Muxol for the elderly Use caution with the elderly because the sensitivity to this drug may be greater than that of normal adults.
Notes on diet when taking Muxol
Read carefully the dietary notes on the leaflet.
Care should be taken in taking the drug. Carefully read the instructions in the container, or your doctor's instructions.
2.4. Unexpected side effects of the drug Muxol 30mg In addition to the effects that Muxol gives you, the following side effects cannot be avoided:
Digestive system disorders:
Frequency not known. : Gastrointestinal disturbances such as nausea, vomiting, stomach pain, rapidly leading to dose reduction.
Immune system disorders:
Rare: hypersensitivity reactions.
Anaphylactic reactions including anaphylaxis, angioedema and pruritus.
Skin and skin tissue disorders:
Rare: skin rash, urticaria.
Not known: serious skin reactions (including erythema multiforme, Stevens-Johnson syndrome/Lyell syndrome, and acute generalized pustular disease).
In these cases, treatment must be paused.
Nervous system disorders:
Not known: headache and dizziness
2.5. Drug interactions Taking ambroxol with antibiotics (cefuroxime, amoxycilin, doxycycline, erythromycin) will increase antibiotic concentration in lung parenchyma. However, there have been no reports of adverse interactions with other drugs in clinical practice. Do not combine Ambroxol with an expectorant (eg atropin) or an antitussive (eg Codeine) as more undesirable effects may occur. And this is also an unreasonable combination. 2.6. Special warnings Muxol tablets contain lactose monohydrate - used as an inactive ingredient, caution should be taken in patients with rare hereditary problems of lactose intolerance due to glucose-galactose malabsorption or deficiency. Intestinal lactase enzymes can lead to bloating, discomfort, abdominal pain, and diarrhea. This medicine contains “parahydroxybenzoate” and may cause allergic reactions. The drug does not cause drowsiness or distraction, so users can still study, drive, operate machinery or do tasks that require high concentration. The drug should not be used in patients with ulcers in the digestive system, because the drug causes mild irritation of the gastric mucosa. Due to the presence of sorbitol, this medicine may cause mild gastrointestinal upset (diarrhea). Cases of serious skin reactions, Stevens-Johnson syndrome (SSJ)/Lyell syndrome, and acute exanthematous pustulosis (AGEP) have been reported with the use of ambroxol hydrochloride. If a rash appears on your skin (including mucosal lesions, eg mouth, throat, nose, eyes, genitals), stop taking Muxol oral solution and contact your doctor. you immediately. Use the correct dose as prescribed by the doctor, do not arbitrarily increase the dose or reduce the dose to achieve the best results. It is necessary to consult a doctor before using the drug for a pregnant woman especially for the first trimester of pregnancy, it is better to take the lowest dose for the shortest possible time to ensure safe. There are no studies to prove that Muxol is excreted in breast milk or not, so caution should be exercised when used in lactating women.
3. How to use Muxol effectively
3.1. How to take Muxol 30mg The drug is prepared in the form of tablets, so do not crush or break the pill before taking it, but take the whole pill. The dosage form of oral solution should be taken with the standard graduated cup that comes with the product. Taking the medicine with boiled and cooled water is the best option. To achieve the best effect of Muxol, it should be taken after meals. 3.2. Dosage of the drug Muxol 30mg Recommended: * Tablets
Adults and children over 10 years old: 30mg/time, 3 times/day. Then twice a day if used for a long time. Children 5 - 10 years old: 15 mg/time, 3 times a day. Then twice a day for prolonged use
* Oral solution
1 tbsp 15ml contains 45 mg of ambroxol hydrochloride.
The average dose of ambroxol hydrochloride is 90 mg per day in 2 divided doses, i.e. 1 tablespoon 2 times a day.
* Intramuscular or intravenous injection Adults and children over 10 years old: 2 - 3 times a day 15 mg Children 5 to 10 years old: 2 to 3 times a day, 7.5 mg each time * Aerosol: Adults and Children over 10 years old: 15 mg/time, 1-2 times a day. Children 5 - 10 years: 7.5 mg/time, 2 - 3 times a day
You should talk to your doctor if you do not feel better or if you do not feel any improvement after 8 to 10 years medication day.
3.3. Overdose There have not been any cases of fatal overdose reported yet, but if any do occur, contact your doctor and initiate symptomatic treatment.
4. How should Muxol be stored?
Store in sealed packaging, at room temperature.
Each drug may have different storage methods. Therefore, carefully read the storage instructions on the packaging, or ask the pharmacist.
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