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Concor drug contains the active ingredient bisoprolol fumarate which is indicated in the treatment of hypertension, coronary artery disease, stable chronic heart failure with reduced left ventricular systolic function... Let's learn about the uses and notes When using the drug Concor through the article below.
1. Uses of the drug Concor tab
"What is Concor 5mg drug?". Concor tab contains the active ingredient bisoprolol, prepared in two strengths, Concor 2.5mg and Concor 5mg. Concor is indicated in the following cases:
Treatment of hypertension; Treatment of angina (coronary artery disease); Treatment of stable chronic heart failure associated with impaired left ventricular systolic function (in combination with diuretics, ACE inhibitors and cardiac glycosides).
2. Dosage of Concor tab
When and how much is the recommended dose of Concor? Accordingly, Concor belongs to the group of prescription cardiovascular drugs, all cases of drug use in treatment need to be prescribed by a doctor. The dosage information below is for reference only, patients absolutely do not arbitrarily use the drug in treatment. The recommended dosage in the treatment of specific conditions is as follows:
Treatment of coronary heart disease and hypertension: The dose of the drug is adjusted for each specific patient based on the clinical condition (especially heart rate and blood pressure). responsiveness of the patient). The starting dose is usually 5mg bisoprolol orally once a day. In the case of patients with mild hypertension (diastolic blood pressure less than 105 mmHg) can take a dose of 2.5mg, taken once a day. In some necessary cases, the dose can be increased to 2 tablets of Concor tab 5mg (10mg/day). The maximum recommended dose is 20mg/time/day.
Treatment of stable chronic heart failure: Drugs used in the treatment of stable chronic heart failure include angiotensin-converting enzyme (ACE) inhibitors (or angiotensin receptor blockers in the case of ACE intolerance), medications. diuretics, beta-blockers and cardiac glycosides as appropriate. Patients with heart failure before being treated with Concor tab 5mg should have a period of examination and monitoring by the treating doctor. Doctors need experience in the treatment of chronic heart failure, the standard starting regimen according to Concor is presented as follows (the regimen may vary depending on the patient's tolerance level):
Week 1: The dose of 1.25mg bisoprolol taken orally once a day, if the patient tolerates it well, the dose will be increased; Week 2: Dose of bisoprolol 2.5mg (1/2 tablet Concor tab 5mg) taken once a day, if the patient tolerates well, the dose will be increased; Week 3: The dose of 3.75mg bisoprolol orally once a day, if the patient tolerates well, the dose will be increased; Week 4 – Week 7: The dose of 5mg bisoprolol orally once a day, if the patient tolerates well, the dose will be increased; Week 8 – Week 11: Dose of 7.5mg bisoprolol orally once a day, if the patient tolerates well, the dose will be increased; Week 12 or later: Dose of 10mg bisoprolol (2 tablets of Concor tab 5mg) orally once daily. Note during the dose adjustment phase or thereafter, if transient worsening of heart failure, bradycardia or hypotension occurs, it is recommended to review the dose of concomitant drugs in the regimen. treatment, besides reducing the dose of Concor or considering discontinuing treatment when necessary.
Duration of treatment: For all indications, Concor tab 5mg is usually for long-term treatment, stopping treatment can be applied when necessary and resuming the dose when appropriate.
Treatment with Concor in patients with liver failure, kidney failure should pay attention to the following issues:
Treatment of coronary artery disease, hypertension: No dose adjustment in patients with hepatic impairment, mild to moderate renal impairment . For patients with severe renal impairment (creatinine clearance less than 20ml/min), patients with severe liver failure should not use more than 10mg/day; Treatment of stable chronic heart failure: There are no studies on the pharmacokinetics of bisoprolol in patients with heart failure with renal or hepatic impairment. Therefore, the use of drugs in these subjects should be very cautious. Elderly: No dose adjustment is required in the elderly.
Children: There are no adequate studies on the use of bisoprolol in children. Therefore, it is not recommended to use the drug in the treatment of children.
3. Concor tab drug side effects
Concor tab 5mg can cause some side effects as follows:
Common: Slow heart rate (for patients with chronic heart failure), increased level of heart failure (for patients with chronic heart failure) , headache, dizziness, vomiting, nausea, diarrhea, low blood pressure, feeling cold or numb in the limbs, asthma, fatigue; Uncommon: Bradycardia, atrioventricular conduction disturbances, increased heart failure, bronchospasm in patients with bronchial asthma or in patients with a history of tracheal obstruction, muscle weakness, cramps, erectile dysfunction; Rare: Syncope, hearing disturbances, decreased lacrimation, allergic rhinitis, hypersensitivity reactions such as erythema, pruritus, rash; hepatitis, nightmares, hallucinations; Very rare: Conjunctivitis, alopecia.
4. Notes when using the drug Concor tab
4.1. Contraindications Contraindicated to use the drug Concor tab 5mg in the following cases:
Patients with acute heart failure or decompensated stages of heart failure need intravenous infusion of drugs that cause myocardial contractility; Patients in shock due to cardiac dysfunction; Patients with severe atrioventricular conduction disturbances (second or third degree atrioventricular block) without a pacemaker; Patients with sinoatrial block, sinus node syndrome; Patients with bradycardia have physical symptoms; Patients with low blood pressure have physical symptoms; Severe bronchial asthma; Severe forms of peripheral artery disease or Raynaud's syndrome; Patients with untreated adrenal tumors; Hypersensitivity to bisoprolol or any ingredient of Concor 5mg; People with metabolic acidosis. 4.2. Note when using the drug Concor tab Be careful when using the drug Concor tab 5mg in the following cases:
Diabetic patients have abnormal blood sugar levels, obvious symptoms of hypoglycemia appear pronounced palpitations, tachycardia, hypoglycemia or sweating; The patient fasts strictly; Are being treated for an allergic condition; Patients with mild atrioventricular conduction disturbances (first degree atrioventricular block); Patients with blood flow disturbances due to vasospasm in coronary artery disease (Prinzmetal's angina); Patients with psoriasis or a history of psoriasis; People with peripheral arterial occlusive disease (pathology may increase, especially at the beginning of treatment. Some notes when using the drug:
On the respiratory system: Avoid using the drug in patients with obstruction. airways (unless there is a compelling clinical indication for use); Allergic reactions: Concor Tab 5mg in particular and beta-1 channel blockers in general may increase sensitivity to allergens , the severity of hypersensitivity reactions due to parasympathetic upregulation can be reduced under beta blockade; General anesthesia: For patients under general anesthesia, the use of beta-channel blockers helps Reduces the risk of ischemia and arrhythmias The current recommendation is to maintain beta-blocker use in the perioperative period; Pheochromocytoma: In patients with adrenal tumors, Concor tab 5mg should only be used in the treatment after alpha receptor blockade; Thyroid toxicity: In patients treated with Concor 5mg may mask symptoms g of hyperthyroidism; Pregnant women: The use of Concor in the treatment of pregnant women requires a prescription from a treating doctor (based on the relationship between benefit and risk).
5. Drug interactions Concor tab
Combination drugs not to be used:
Treatment of stable chronic heart failure: Class I antiarrhythmic drugs (disopyramide, quinidine, lidocaine, flecainide, phentoin, propafenon) may increase the inhibitory effect of Concor. cardiac contractility and atrioventricular impulse conduction; Calcium channel blockers diltiazem and verapamil can slow AV impulse conduction and decrease myocardial contractility when used concurrently with Concor 5mg. In particular, intravenous administration of verapamil in patients on beta-blocker therapy can cause atrioventricular block and severe hypotension; Central antihypertensive drugs such as methyldopa, clonidine, rilmenidin, moxonodin... can reduce cardiac output, heart rate as well as vasodilation due to decreased central sympathetic tone.; Combinations requiring caution:
Dihydropyridine calcium channel blockers (eg nifedipine) may increase the risk of hypotension when co-administered with Concor 5mg; Class III antiarrhythmic drugs such as amiodarin may increase the inhibitory effect of atrioventricular impulse conduction of Concor 5mg; Topical beta-channel blockers such as glaucoma eye drops... may have a synergistic effect on the systemic effects of Concor; Parasympathomimetic agents increase the inhibitory effect of atrioventricular impulse conduction and increase the risk of bradycardia when used with Concor 5mg; Class I antiarrhythmic drugs such as disopyramid, quinidine, phenytoin, lidocaine, propafenon... can increase the inhibitory effect of atrioventricular impulse conduction and cardiac contractility of the drug Concor 5mg; Anesthesia may increase the risk of cardiac depression of Concor 5mg leading to hypotension; Cardiac glycosides can prolong the conduction time of impulses, thus reducing the heart rate when used together with Concor tab 5mg; Non-steroidal anti-inflammatory drugs may reduce the antihypertensive effect of Concor 5mg; Beta-sensitizing drugs such as dobutamin, isoprenalin... used together with Concor 5mg can reduce the effect of both. Combinations to consider:
Mefloquine may increase the risk of bradycardia when used with Concor 5mg; MAO inhibitors may reduce the antihypertensive effect of beta-channel blockers; Rifampicin concomitant use with bisoprolol may reduce the half-life of bisoprolol; Ergotamine derivatives: Increased peripheral circulatory disorders. Concor drug contains the active ingredient bisoprolol fumarate is indicated in the treatment of hypertension, coronary heart disease, stable chronic heart failure with reduced left ventricular systolic function... To ensure the effectiveness of treatment and avoid the side effects. side effects, patients need to use the drug strictly according to the instructions of the doctor, professional pharmacist.
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