Uses of Tandorex

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1. What is Tandorex?

Tandorex contains the main ingredient Cyclosporin - a strong immunosuppressant, with specific effects on lymphocytes, mainly T lymphocytes. Cyclosporine's mechanism of action is to form complexes with protein receptors. cyclophilin. This complex binds calcineurin (which is important in the production of lymphokines, including interleukin-2) and inhibits its activity; thereby inhibiting the cell-mediated immune response.
Tandorex has little effect on bone marrow but is highly nephrotoxic; Used to prevent the body's natural immunity to remove foreign grafts after organ transplant surgery.
Tandorex is well absorbed from the gastrointestinal tract and reaches peak blood concentrations in 2 to 6 hours. After entering the systemic circulation, the drug binds to plasma proteins about more than 90%, most of which are lipoproteins; Widely distributed throughout body tissues and fluids, crosses the placenta and breast milk. The drug is metabolised in the liver and finally eliminated in the faeces, with urinary concentrations of about 6%.

2. What are the effects of Tandorex?

Tandorex drug is indicated in the following pathological cases
Patients after organ transplant surgery, bone marrow transplant. Endogenous uveitis. Autoimmune diseases of the body: Psoriasis, Atopic Dermatitis, Rheumatoid Arthritis, Nephrotic Syndrome,... Do not use Tandorex in cases
Patients are allergic to Cyclosporin or any other disease. any other ingredient of the drug. Patients with moderate to severe renal impairment are not indicated for the use of Tandorex. Patients with uncontrolled hypertension. Severe infectious diseases have not controlled the cause. Patients with a history of or current malignancies in addition to malignancies of the skin.

3. Note when using Tandorex medicine

Tandorex is a drug that is prescribed by a specialist doctor and the treatment process must be monitored and supervised by medical staff at a medical facility equipped with adequate emergency resuscitation facilities. Tandorex should only be combined with corticosteroids, not with other immunosuppressive agents because of the increased risk of infection and the risk of lymphoma tumorigenesis. For organ transplant patients, especially liver transplant patients, blood levels of the drug should be monitored and dose adjusted accordingly to avoid toxicity if drug levels are high or to avoid graft rejection if drug levels are low. Tandorex suppresses the body's immune response, so patients taking the drug will have an increased risk of bacterial, viral, fungal,... and opportunistic infections. Monitor skin manifestations, avoid exposure to strong ultraviolet light when taking Tandorex because of the risk of lymphoma or skin malignancies. Check liver function, kidney function, blood pressure, uric acid, concentration of K+, Mg++ ions before and during drug treatment. The drug can cross the placenta, breast milk and affect the development of the fetus and nursing infant. Therefore, pregnant and lactating women should not use Tandorex.

4. Tandorex drug interactions

Combination with drugs phenobarbital, phenytoin, carbamazepine, rifampicin, isoniazid can reduce the concentration of Tandorex in the blood. Co-administration with clarithromycin, diltiazem, verapamil erythromycin, azithromycin, fluconazole, itraconazole, nicardipine, ketoconazole, acyclovir,... increases the concentration of Tandorex in the blood, increasing nephrotoxicity. Concomitant use with cholesterol-lowering drugs (lovastatin) may increase muscle side effects such as myalgia, myositis, rhabdomyolysis, acute renal failure. Immunosuppressive agents other than corticosteroids increase the risk of lymphoma tumorigenesis and infection. Potassium-containing foods, drugs containing potassium and potassium-sparing diuretics should not be used with Tandorex because of the risk of increased plasma potassium.

5. Dosage and usage

5.1. How to use Tandorex is made in the form of soft capsules, content of 100mg. Swallow the tablet whole with water, avoid crushing or breaking the tablet. The drug can be taken during or after a meal, do not take it with grapefruit or grapefruit juice. 5.2. Dosage: Organ transplant patients:
Starting dose: 10-15 mg/kg x 2 times 12 hours before surgery. Postoperative dose: 10-15mg/kg/time x 2 times/day for 14 days after surgery. Maintenance dose: 1-3 mg/kg/time x 2 times/day (depending on blood concentration). Bone marrow transplant patients:
Starting dose: 12.5-15 mg/kg/ at least 12 hours before transplantation. Maintenance dose: 12.5 mg/kg/day continuously for 3 to 6 months. Reduce dose gradually and discontinue after at least 12 months. Endogenous uveitis:
Starting dose: 2.5mg/kg/time x 2 times/day. Use until improvement of ocular symptoms. If symptoms do not improve or severe illness persists: 3.5mg/kg/time x 2 times/day. Use for a short time then reduce the dose. Psoriasis:
Starting dose: 2.5 mg/kg/day divided into 2 oral doses. Increase dose from 0.5-1mg/kg after 4 weeks of treatment. Maximum dose: 5mg/kg/day divided into 2 oral doses. Atopic dermatitis:
Dosage in adults and children over 16 years old: 2.5-5mg/kg/day divided into 2 oral doses. Use the drug for up to 8 weeks continuously. Rheumatoid arthritis:
Starting dose: 1.5mg/kg/time x 2 times/day. Use this dose for the first 6 weeks then gradually increase the dose. Maximum dose: 5mg/kg/day for 12 consecutive weeks. Nephrotic syndrome:
Dosage in adults: 5mg/kg/day in 2 divided doses. Dosage in children: 6mg/kg/day, divided into 2 oral doses.

6. Tandorex side effects

Some unwanted effects may be encountered when using Tandorex medicine
Fatigue, headache, feeling of paresthesia in the skin. Anaphylactic reaction. Decreased kidney function. Increased and uncontrolled blood pressure. Essential tremors. Digestive dysfunction. Hypertrophy, inflammation of the gum area. Bacterial, viral, fungal or other opportunistic infections. In summary, Tandorex is an immunosuppressive drug indicated in autoimmune diseases of the body or used after organ transplant surgery, bone marrow transplant. Medicines must be prescribed by a mandatory prescription and supervised by a specialist in medical facilities that are fully equipped with emergency support facilities.

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