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Solmiran drug with the main ingredient Amikacin is used in the treatment of sensitive infections in the respiratory tract, bone and joint system, central nervous system, sepsis,... Let's find out more details about the line. Solmiran drug through the article below.
1. What is Solmiran?
Solmiran belongs to the group of antiparasitic, anti-infective, anti-viral, anti-fungal drugs. Solmiran is prepared in the form of an infusion solution and packaged in a box of 1 vial of 100 ml.Solmiran medicine contains the main ingredient Amikacin (in the form of Amikacin sulfate) 500mg/100ml and other excipients with sufficient drug content.
2. Indications for taking Solmiran
Solmiran is indicated for short-term treatment of severe infections caused by susceptible strains: Pseudomonas sp., Enterobacter sp., Proteus sp., Serratia sp., Klebsiella sp., Escherichia coli, Acinetobacter sp., Citrobacter freundii.
Amikacin is effective in the treatment of sepsis in adults and neonates, central nervous system (including meningitis), severe infections of the respiratory tract, bones and joints, infections caused by burns , skin and soft tissue, intra-abdominal infections (peritonitis), postoperative infections.
Amikacin is also effective in severe complications and recurrent urinary tract infections caused by these bacteria.
Should be combined with antibiotics of the beta-lactam family with Solmiran for optimal effect.
3. Dosage, how to use Solmiran effectively
How to use Solmiran:
Solmiran is used intramuscularly or intravenously. Intravenous infusion for adults: Mix Amikacin 500mg into 100-200ml of normal infusion such as 5% Dextrose solution or 0.9% sodium chloride solution. The appropriate dose should be infused with Amikacin over 30-60 minutes. Intravenous infusion for children: The volume of Amikacin infusion depends on the patient's needs, but should be enough to be given in 1 - 2 hours in young children or 30 - 60 minutes in older children. Solmiran dosage:
Solmiran dose is calculated according to Amikacin and is the same when administered intramuscularly or intravenously. Amikacin dosage should be based on estimated ideal body weight. The usual dose of Amikacin for adults and older children with normal renal function is 15mg Amikacin/kg/day, divided into equal doses given every 8 or 12 hours. The daily dose of Amikacin should not exceed 15mg Amikacin/kg or 1.5g Amikacin. Neonates and premature infants: The first loading dose is 10mg Amikacin/kg, followed by 7.5mg Amikacin/kg every 12 hours. In case of patients with kidney damage, it is necessary to measure serum Amikacin levels and carefully monitor renal function to adjust the dose accordingly. In case of renal failure, the first dose is 7.5mg Amikacin/kg, subsequent doses are calculated according to the serum creatinine concentration (mg/100ml): Time between 2 doses = 9 x serum creatinine concentration serum (mg/100ml).
4. Contraindications to the use of Solmiran
Solmiran drug is not used in the following cases:
Patients with a history of hypersensitivity, allergy to Amikacin as well as to other Aminoglycosides. The patient has weakness.
5. Notes when using Solmiran for treatment
Care should be taken when using Solmiran in patients with ear and kidney disease. If it is necessary to use Solmiran, renal function and hearing should be monitored regularly. Patients with renal impairment should take Amikacin only when absolutely necessary and calculate the dose according to creatinine clearance. Repeated or prolonged use of Amikacin should be avoided, especially in the elderly. If you are pregnant, the use of Solmiran may cause harm to the unborn baby. Amikacin is excreted in breast milk, so in case of nursing women, use Solmiran with caution.
6. What drugs interact with Solmiran?
The following are some of the reported drug interactions Solmiran such as:
Drugs in the Aminoglycoside group, diuretics (Furosemide diuretics), Polymycin, Curare, Cisplatin in combination with Solmiran increase toxicity. on the kidneys and ears.
7. Side effects when taking Solmiran
During the use of Solmiran drug, patients may encounter some unwanted side effects such as:
When taking high doses of Solmiran for a long time, it may cause neurotoxicity, causing deafness, loss of balance. plain. Acute muscle paralysis, difficulty breathing. Increased serum creatinine, blood azote, blood albumin. Urine has red blood cells/white blood cells, casts and oliguria. Changes in kidney function. Skin rash, anemia and hypotension, nausea, drug fever, headache, paresthesias, myoclonus, eosinophilia, arthralgia are rare.
8. What to do in case of an overdose of Solmiran?
In the event of an overdose of Solmiran or a toxic reaction, consider hemodialysis or peritoneal dialysis to accelerate the elimination of Amikacin from the body. In case of infant overdose of Amikacin, blood transfusion can be changed. The above is important information about the uses, dosage and precautions when using Solmiran medicine. Note: Solmiran is prescribed by a doctor, do not self-medicate without a prescription from a medical professional.
