This is an automatically translated article.
The drug Pfertzel is made in the form of tablets, the main ingredients are clopidogrel and aspirin. The drug is indicated in the treatment of certain diseases related to the heart. To ensure effective use, avoid side effects, users need to strictly follow the instructions of the doctor or pharmacist.
1. Uses of the drug Pfertzel
Pfertzel 75mg tablet contains clopidogrel and aspirin ingredients. Clopidogrel is a prodrug, which is metabolized by CYP450 to an active substance that inhibits platelet aggregation. Aspirin (acetylsalicylic acid) irreversibly inhibits platelet aggregation until new platelets form. The combined use of clopidogrel and aspirin increases the therapeutic effect on collagen platelet aggregation compared with either drug alone. However, due to the increased bleeding side effects if the two drugs are used together, users need to be careful.
Indications of Pfertzel:
Primary prevention of thromboembolic disorders: stroke, myocardial infarction, peripheral artery disease; Control, secondary prevention in atherosclerotic patients with recent stroke, myocardial infarction, or established peripheral arterial disease. Contraindications of Pfertzel:
Patients with hypersensitivity to clopidogrel, aspirin or other ingredients in the drug; Pregnant women, nursing mothers; People with medical conditions such as bleeding/ulcer of the stomach - duodenum, endoscopic bleeding, retinal bleeding; Patients with severe liver failure; Patients with severe renal failure; Patients with moderate and severe heart failure; People with thrombocytopenia; In relation to aspirin: Do not use aspirin for people with symptoms of asthma, rhinitis, urticaria when taking aspirin or non-steroidal anti-inflammatory drugs in the past.
2. How to use and dose Pfertzel
How to use: Patients need to take the drug orally.
Reference dosage:
Prophylaxis of ischemia due to coronary artery disease, cerebrovascular accident, myocardial infarction: Take 1 tablet/time/day; Acute coronary syndrome: Attack dose of 4 tablets/day, maintenance dose of 1 tablet/day. Overdose: Taking an overdose of Pfertzel can lead to prolonged bleeding time, bleeding complications. Appropriate treatment is required if bleeding is observed. There is currently no specific antidote for clopidogrel. Diuresis can be caused by alkalization of the urine to increase the elimination of salicylates. However, oral bicarbonate should not be used (because it increases salicylate absorption). If acetazolamide is used, consider the increased risk of severe metabolic acidosis and salicylate toxicity (due to increased penetration of salicylates into the brain because of metabolic acidosis). In case of serious overdose, blood transfusion, hemodialysis, and peritoneal dialysis can be performed if necessary. Simultaneously, monitor for pulmonary edema, convulsions, and administer appropriate therapy if necessary. If necessary, blood transfusion or vitamin K can be used to treat bleeding.
Missed dose: If a dose of Pfertzel is missed, the patient should take it as soon as possible. If it is almost time for your next dose, you can skip the missed dose and take your next dose as scheduled.
3. Side effects of the drug Pfertzel
When using Pfertzel, patients may experience side effects such as: bleeding, increased bleeding time, gastritis, abdominal pain, digestive disorders, rash and other skin disorders, ... In addition, patients may also have leukopenia, thrombocytopenia, insomnia, fatigue, irritability, restlessness, anaphylaxis, which causes impaired liver and kidney function, shortness of breath, bronchospasm, etc. ..
When experiencing side effects of the drug Pfertzel, the patient should stop taking the drug and immediately notify the doctor for timely treatment advice.
4. Be careful when using Pfertzel
Some notes before, during and after using Pfertzel, patients need to remember:
Pfertzel increases the risk of bleeding due to surgery, trauma or other diseases. Therefore, the drug should be discontinued 7 days before surgery; Limit and be cautious when using Pfertzel for people with severe liver disease; Pfertzel should be used with caution concurrently with anticoagulants or when there is a risk of other bleeding; Do not combine Pfertzel with non-steroidal anti-inflammatory drugs and glucocorticoids; When using Pfertzel to treat patients with mild heart failure, liver disease, kidney disease, especially when used concurrently with diuretics, the risk of fluid retention and decreased renal function should be considered; In some children, when taking aspirin, they have had Reye's syndrome, so it is necessary to limit the use of the drug for children; Elderly people taking Pfertzel may experience aspirin toxicity (due to decreased kidney function) so a lower dose than the usual dose is required.
5. Pfertzel drug interactions
Some drug interactions of Pfertzel include:
Related to clopidogrel:
Co-administration of clopidogrel with NSAIDs increases the risk of stomach ulcers and intestinal bleeding; Co-administration of clopidogrel with coumarin, dasatinib, agatroban, heparin, ginkgo biloba and iloprost increases the risk of bleeding; Increased risk of bleeding if clopidogrel and drotrecogin alfa are taken within 7 days of each other; The use of clopidogrel may increase bupropion levels and side effects such as dizziness and gastrointestinal upset. In relation to aspirin:
Concomitant use of aspirin with indomethacin, naproxen and fenoprofen reduces the concentration of these drugs; The interaction of aspirin with warfarin increases the risk of bleeding; The drugs methotrexate, hypoglycemic agents sulphonylurea, valproic acid, phenytoin will increase the concentration of this drug in the serum and increase toxicity; Other aspirin interactions include: antagonism of urinary sodium by spironolactone, blockade of active transport of penicillin from the cerebrospinal fluid into the blood. Aspirin reduces the effect of uric acid drugs such as probenecid and sulphinpyrazole. Potentially Fatal Interactions: Use of clopidogrel and aspirin increases the risk of bleeding if taken with dabigatran.
During the course of using Pfertzel, the patient should follow all the instructions of the doctor. In case of any adverse side effects, the patient should immediately notify the doctor for advice and timely treatment.
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