This is an automatically translated article.
Savi Tenofovir 300 belongs to the group of drugs to treat parasites, anti-infectives, antivirals and fungi. Complying with the indications, the dose of Savi Tenofovir 300 will help patients improve treatment efficiency and avoid unwanted side effects.
1. What is Savi Tenofovir 300?
Savi Tenofovir 300 contains the active ingredient Tenofovir disoproxil fumarate 300mg, is prepared in the form of film-coated tablets, packaged in the form of: Box containing 3 blisters, 1 blister of 10 tablets.
2. Uses of Savi Tenofovir 300
2.1. Savi Tenofovir 300 Structure of the active ingredient Tenofovir Disoproxil Fumarate contained in the drug Savi Tenofovir 300 is a cyclic diester nucleotide, the fumarate salt form of the prodrug Tenofovir Disoproxil. The drug hydrolyzes to tenofovir after absorption, which inhibits the hepatitis B virus (HBV) DNA Polymerase enzyme, which is Tenofovir diphosphate and HIV reverse transcriptase. Tenofovir diphosphate breaks the DNA strand after entering viral DNA, this effect is due to Tenofovir diphosphate competing with deoxyribonucleotides. Tenofovir diphosphate weakly inhibits vertebrate gamma DNA polymerase and mammalian alpha and beta-DNA polymerases.
2.2. Indications of the drug Savi Tenofovir 300 Savi Tenofovir 300 is indicated for the treatment of the following cases:
HIV-1 infection in children ≥ 12 years old and adults: When treating, it is necessary to combine Savi Tenofovir 300 with other drugs. other antiretrovirals. Use of Savi Tenofovir 300 for the treatment of chronic hepatitis B in adults. For chronic hepatitis B in children ≥ 12 years of age with evidence of active viral replication, compensated liver function, active hepatitis, prolonged elevation of ALT (Alanine Amino Transferase) enzyme is indicated. Treatment with Savi Tenofovir 300. In addition, Savi Tenofovir 300 is also used to prevent health workers at risk of HIV-1 infection when they have to come into contact with specimens (blood, body fluids, etc.) . When used, it is necessary to combine with other antiretroviral drugs. 2.3. Contraindications of the drug Savi Tenofovir 300 Savi Tenofovir 300 is contraindicated for use in the following subjects:
Patients with hypersensitivity to any component of the drug including the active ingredient and excipients contained in Savi Tenofovir 300. Savi Tenofovir 300 should not be used in patients with severe renal impairment (creatine clearance < 30 ml/min), in patients with abnormal neutrophil counts or in abnormal hemoglobin levels. Do not use Savi Tenofovir 300 concurrently with other drugs containing Tenofovir alafenamide, Tenofovir disoproxil fumarate, Adefovir dipivoxil.
3. Usage and dosage of Savi Tenofovir 300
3.1. How to take Savi Tenofovir 300 Savi Tenofovir 300 is better absorbed when taken with high-fat foods, so it should be used during or immediately after eating. In cases when the patient has difficulty swallowing, Savi Tenofovir 300 tablets can be dissolved with at least 100ml of boiled water or juice to make it easier to swallow.
3.2. Dosage of Savi Tenofovir 300 For adults, the specific dose indicated in each case is as follows:
Using Savi Tenofovir 300 in the treatment of HIV-1 infection: Take 1 tablet once a day. Prevention of occupational HIV infection: Take 1 tablet a day and combine with other anti-HIV drugs according to a 2-drug regimen. Non-occupational HIV prevention: Take 1 tablet once a day, in combination with at least 1 other anti-HIV drug. Used for the treatment of hepatitis B: 2 tablets per day. For patients with hepatic impairment: No dose adjustment is required in this patient. In patients with renal impairment, the dose should be adjusted to suit each level. Patients with renal failure should strictly adhere to the dosage prescribed by the doctor.
4. Drug interactions
Do not use Savi Tenofovir 300 concurrently with other drugs with the active ingredient Adefovir dipivoxil or Tenofovir. Drugs with nephrotoxicity such as: Fosscanet, Amphotericin B, NSAIDs should not be used together with Savi Tenofovir 300. It is necessary to closely monitor the use of Didanosine with Savi Tenofovir 300. The combination of Ritonavir + Lopinavir or Atazanavir when used with Savi Tenofovir 300 may cause interactions causing unwanted effects.
5. Undesirable effects
When patients use Savi Tenofovir 300 for treatment, they may experience the following undesirable effects:
Common side effects such as: Headache, muscle fatigue, bloating, diarrhea, loss of appetite eating, abdominal pain, nausea, vomiting, dyspepsia, hypophosphatemia, neutropenia, increased results of urine glucose tests, AST, ALT. Less common side effects such as: liver, kidney poisoning, abdominal pain.
Rare side effects include: lactic acidosis, loss of appetite, abdominal pain, diarrhea, general discomfort, tachypnea, weakness, muscle pain, drowsiness, nausea, cramps), liver toxicity, protein urinary retention, acute renal failure, tubular necrosis, Fanconi syndrome, pancreatitis.
When experiencing any side effects when using Savi Tenofovir 300, you must stop the drug immediately and notify the doctor for a reasonable treatment.
6. Pay attention to the use of Savi Tenofovir 300
Do not use Savi Tenofovir 300 on pregnant and lactating women.
When using the drug Savi Tenofovir 300 can cause symptoms of headache, dizziness, so it should be used with caution when driving, operating machinery or doing jobs that require high concentration
The above is information about Uses, dosages and precautions when using Savi Tenofovir 300. To ensure safety for health and maximize the effectiveness of treatment, patients need to take Savi Tenofovir 300 exactly as directed by their doctor. Do not arbitrarily increase or decrease the dose or give prescriptions to others to use.
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