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Tenofovir 300mg belongs to the group of antiretroviral drugs indicated in combination with other drugs in the treatment of HIV type 1, prevention of HIV infection type 1 in patients at high risk of being infected with the virus... Let's learn about the uses. , notes when using Tenofovir 300mg through the article below.
1. Uses of Tenofovir 300mg
Tenofovir 300mg what effect? Tenofovir 300mg medicine contains the active ingredient Tenoforvir disoproxil fumarate 300mg in the form of film-coated tablets. Tenofovir 300mg is indicated in the following cases:
In combination with immunosuppressive drugs in the treatment of HIV type 1 infection in adults; Combination with other antiretroviral drugs in the prevention of HIV infection in people at high risk of viral infection; Treatment of chronic hepatitis B. Tenoforvir 300mg is contraindicated in patients with hypersensitivity to any of the ingredients.
2. Dosage of Tenofovir 300mg
Tenofovir 300mg brand name drug belongs to the group of prescription drugs. The dose of the drug is prescribed by the treating doctor based on the medical condition. Patients absolutely do not arbitrarily use Tenofovir 300mg without a doctor's prescription. Some recommendations on drug dosage are as follows:
Treatment of HIV in adults: Take 1 tablet/time x 1 time/day in combination with other antiretroviral drugs; Prevention of HIV infection after exposure to HIV virus due to occupational causes: Take 1 tablet x 1 time/day in combination with other drugs. Time to start treatment as soon as possible, the dose should be maintained for 4 weeks; Prevention of HIV infection after non-occupational exposure to HIV virus: Take 1 tablet/time x 1 time/day. Time to start treatment as soon as possible, the dose should be maintained for 28 days; Treatment of chronic hepatitis B: Take 1 tablet x 1 time/day for 48 weeks. The dose of Tenofovir 300mg in patients with renal failure should be adjusted to suit the condition of the patient.
3. Tenofovir 300mg . side effects
Tenofovir 300mg can cause some side effects as follows:
Side effects on the gastrointestinal tract: Abdominal pain, nausea, flatulence, diarrhea, loss of appetite, indigestion...; Skin side effects: Skin rash, small acne; Side effects on the liver: Increased liver enzymes; Other side effects: Hypertriglyceridemia, hyperglycemia, neutrophil deficiency; Acute renal failure, Fanconi syndrome; Lactic acidosis associated with symptoms of severe hepatomegaly, fatty liver. In case of experiencing unwanted effects, the patient should stop using Tenofovir 300mg and notify the treating doctor for timely treatment.
4. Notes when using Tenofovir 300mg
Some notes when using Tenofovir 300mg as follows:
Tenofovir 300mg in particular and antiretroviral drugs in general can change the distribution of body fat such as central obesity, mammary gland hypertrophy , anterior-posterior neck hypertrophy, drug-induced Cushing's syndrome; Effects on the skeletal system: Using a combination of Tenofovir and Lamivudin, Efavirenz in HIV-infected patients showed a decrease in mineral density in the lumbar spine, an increase in serum parathyroid hormone levels, and an increase in the concentration of 4 factors. biochemical factors in bone metabolism. Therefore, HIV-infected patients with a history of fractures and high risk of osteoporosis should be closely monitored. Although the effectiveness of vitamin D and calcium supplements in these populations has not been proven, they may be beneficial; For pregnant women: There are no studies demonstrating the safety and effectiveness of Tenofovir 300mg in pregnant women. Therefore, the use of Tenofovir is contraindicated in these subjects; Lactation: There are no studies demonstrating the excretion of Tenofovir 300mg in breast milk. Therefore, Tenofovir should not be used in lactating women.
5. Drug interactions
Tenofovir 300mg drug interacts with drugs that are excreted by the kidneys or drugs affected by the kidneys such as Cidofovir, Acyclovir, Valacyclovir, Ganciclovir, Valganciclovir... increasing the concentration of these drugs in the blood plasma, increasing the risk of interactions. unwanted use.
Tenofovir 300mg interacts synergistically or synergistically with HIV Proteaz inhibitors such as Atazanavir, Amprenavir, Ritonavir, Indinavir, Saquinavir...
Tenofovir 300mg interacts with or interacts synergistically with reverse transcriptase inhibitors such as Didanosin, Abacavir, Lamivudin, Emtricitabine, Zalcitabine, Stavudin, Zidovudine.
Oral contraceptives containing Norgestimat and Estradiol interact pharmacokinetics with Tenofovir 300mg.
Drug interactions occur reducing the therapeutic effect of Tenofovir 300mg, increasing the risk of unwanted effects. Therefore, patients need to inform the treating doctor about the drugs and functional foods being used to ensure safety and effectiveness in treatment.
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