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Safoli is used in the treatment of certain conditions. So what is the use of Safoli medicine and how to use this medicine?
1. Uses of the drug Safoli
Safoli pills are made in the form of capsules, with the main ingredients in each tablet including:
Fe(III) 166.67mg Folic acid 0.35mg Iron (III) polymaltose hydroxide (IPC): Iron is an important ingredient. make up the hemoglobin molecule. IPC is composed of many polymaltose molecules surrounding the iron(III) hydroxide core by structural bonds similar to ferritin, so diffusion across the mucosal membrane is about 40 times less than the iron(II) salt form. When used in high doses, iron exists in an ionic state easily causing harmful side effects such as intestinal disorders, iron poisoning, tooth enamel discoloration.
The effectiveness of iron(III) hydroxide polymaltose in the prevention and treatment of iron deficiency anemia has been demonstrated in clinical trials. The hemoglobin index increased more rapidly with iron(III) hydroxide polymaltose than with common iron salts. Specifically, the hemoglobin index increased by 0.8 mg/dl per week of using this active ingredient.
Folic acid is a B vitamin. In the human body, folic acid is reduced to tetrahydrofolate, a coenzyme involved in many metabolic processes, including the synthesis of purine or pyrimidine nucleotides. So it has an effect on DNA synthesis. Folic acid is also involved in some amino acid metabolism. Folic acid is an indispensable element for normal nucleoprotein synthesis and erythropoiesis. Folic acid deficiency causes megaloblastic anemia similar to vitamin B12 deficiency anemia.
Safoli is indicated in the following cases:
Prophylaxis and treatment of iron and folic acid deficiency during pregnancy in women when dietary intake is insufficient from the 4th month of pregnancy. Safoli is only for pregnant women. Safoli is contraindicated in the following cases:
Iron overload, especially in cases of anemia such as thalassemia, myelosuppression anemia, persistent anemia. Hypersensitivity to any of the ingredients of the drug.
2. Dosage and how to use Safoli
Safoli is to be taken orally, the tablet needs to be swallowed whole. Do not smoke, chew or hold Safoli tablets in your mouth, so take the medicine with a large glass of water. Safoli tablets can be taken before meals or during meals.
Dosage of Safoli drug should be according to the prescription of a specialist. Dosage of Safoli is as follows: Use 1 tablet per day during the last 6 months of pregnancy.
Cases of iron salt overdose have been reported, especially in children, due to accidental ingestion of large amounts of the drug. Symptoms of drug overdose include:
Signs of irritation Necrosis of the digestive mucosa causing abdominal pain, vomiting, bloody diarrhea. Accompanied by shock due to acute renal failure Liver function impairment Convulsions, coma. Treatment of Safoli overdose should be initiated as soon as possible by gastric lavage with 1% sodium bicarbonate solution. Depending on blood iron levels, the use of an iron-chelating agent may be recommended, namely Deferoxamine.
If you forget a dose of Safoli, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue your Safoli dosing schedule as usual. Do not use Safoli with a double dose to make up for a missed dose.
3. Side effects of the drug Safoli
During the use of Safoli medicine, you may encounter some side effects of the drug.
Side effects of Safoli drugs related to iron:
Common side effects include: Constipation Diarrhea Stomach bloating Abdominal pain Pale stools Nausea. Less common side effects include: Laryngeal edema. Unusual reactions Indigestion Vomiting Gastritis. Itching, rash, erythema. Side effects of unknown frequency include: Hypersensitivity Urticaria. Teeth discoloration Mouth ulcers Gastrointestinal melanosis. Side effects of Safoli drug related to folic acid of unknown frequency include:
Anaphylactic reactions. Digestive disorders Angioedema Atopic dermatitis Urticaria.
4. Interaction of Safoli with other drugs
Interactions with Safoli drugs related to iron:
Co-administration of the drug is not recommended with: Parenteral iron (salts): Causes fainting or shock due to rapid release of iron from the complex and saturated transferrin . Combination should be considered with: Acetohydroxamic acid: Due to reduced absorption of both drugs when used together due to the formation of chelate complexes with iron ions. Combination should be used with caution when used with: Bisphosphonates: Decreased absorption of bisphosphonates when used with oral iron salts. You should take Safoli medicine away from the time of taking the bisphosphonates (minimum from 30 minutes to more than 2 hours, depending on the type of bisphosphonate). Calcium: Reduces absorption of iron salts taken orally. Use Safoli medicine away from meals and do not take with calcium. Cyclins (oral): Iron salts reduce the absorption of oral cyclins (due to complex formation). Take Safoli away from cyclins (more than 2 hours if possible). Entacapon: Iron salts reduce the absorption of entacapone by forming chelate complexes between these two substances. Take Safoli away from entacapon (more than 2 hours, if possible). Fluoroquinolone antibiotics, zinc, thyroid hormone, levodopa/carbidopa, penicillamine: Iron salts reduce the absorption of these drugs. Take Safoli away from these medications (more than 2 hours, if possible). Methyldopa: Iron salt reduces absorption of methyldopa (due to complex formation). Therefore, Safoli should be used at a distance from methyldopa (more than 2 hours, if possible). Salts, oxides and hydroxides of magnesium, aluminum and calcium (topical use in the gastrointestinal tract): These substances reduce the absorption of iron salts. Therefore, Safoli should be used at a distance from these drugs (more than 2 hours, if possible). Cholestyramine reduces the absorption of iron salts when used together. You should take Safoli medicine away from the time of cholestyramine (before 1-2 hours or after 4 hours). Safoli drug interactions related to folic acid:
Phenobarbital, phenytoin, primidone, fosphenytoin: Folic acid reduces plasma concentrations of anticonvulsants by increasing their metabolism by the liver. The physician will need to monitor clinically and monitor the plasma concentrations of anticonvulsants and adjust the dose of these drugs if necessary, during the period of use of Safoli and after its discontinuation. In addition to the above information, if during the course of taking the drug, the patient has any further questions, they can contact the doctor for in-depth advice.
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