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Tomethrol is a non-steroidal anti-inflammatory drug whose main ingredient is methylprednisolone. Tomethrol is effective in the treatment of adrenocortical abnormalities with allergic disorders, diseases of the skin, gastrointestinal tract, respiratory tract, hematology,...1. What does Tomethrol do:
The main ingredient methylprednisolone in Tomethrol has the general properties of the glucocorticoid prednisolone but is less soluble and more difficult to metabolize and therefore has a longer duration of action. Glucocorticoids penetrate cell membranes and bind to specific plasma cell receptors. These complexes then enter the cell nucleus, bind to DNA (chromosomes) and stimulate the transport of messenger RNA and protein synthesis by various enzymes thought to be primarily responsible for many properties after systemic use.
Tomethrol is usually indicated in the following pathological cases:
Abnormal function of the adrenal cortex Atopic dermatitis, respiratory inflammation, arthritis, rheumatism Rheumatoid arthritis Lupus erythematosus, bronchial asthma, ulcerative colitis Hemolytic anemia, granulocytopenia Severe allergies including anaphylaxis Cancer treatment: acute leukemia, lymphoma, breast cancer, prostate cancer Primary nephrotic syndrome Contraindications Tomethrol's indications:
Severe infections (except septic shock and meningitis) Patients with hypersensitivity to methylprednisolone Viral, fungal or tuberculosis skin lesions Patients receiving live viral vaccines
2. Dosage of Tomethrol
Depending on the subjects and treatment goals, the dose of Tomethrol will be different, specifically as follows:
For adults:
The starting dose is 4-48 mg/day in a single dose or in divided doses. Multiple Sclerosis 160 mg/day x 1 week, followed by 64 mg every 2 days x 1 month Rheumatoid arthritis: initial dose 4-6 mg/day, acute episodes may increase dose up to 16 -32 mg/day then rapidly tapered off Severe rheumatism: 0.8 mg/kg/day in divided doses, then single dose Acute asthma attack: 32-48 mg/day, for 5 days . Upon resolution of an acute attack, methylprednisolone is rapidly tapered off. 1.6 mg/kg for 6 weeks, then reduce dose for 6-8 weeks Immune hemolytic anemia: 64 mg/day orally for 3 days, must be treated for at least 6-8 weeks Sarcoidosis: use dose of 0.8 mg/kg/day helps in remission, low maintenance dose of 8 mg/day For children:
Adrenal insufficiency, dose 0.117 mg/kg divided in 3 divided doses Other indications can be dose of 0.417 - 1.67 mg/kg divided into 3 or 4 times
3. Tomethrol side effects:
In some patients, long-term use of Tomethrol may experience side effects such as:
Insomnia, excitability Dizziness, mental confusion, convulsions, delirium, hallucinations Indigestion Indigestion Hirsutism Diabetes mellitus Arthralgias Cataracts, glaucoma Nosebleeds Angioedema, hypertension Acne, skin atrophy, bruising, tissue hyperpigmentation Cushing's syndrome, pituitary-adrenal suppression, growth retardation, intolerance Glucose loading, hypokalemia Gastric ulcer, nausea, vomiting, abdominal distention, esophageal ulceration, pancreatitis Muscle weakness, osteoporosis, fracture Hypersensitivity reactions
4. Be careful when using Tomethrol
Some general notes when using Tomethrol include:
Caution when using Tomethrol in patients with osteoporosis, new vascular connections, mental disorders, peptic ulcers, diabetes, Hypertension, heart failure and growing children With caution when using systemic corticosteroids in the elderly, the lowest dose and shortest duration should be used. Long-term treatment or under stress When taking high doses of Tomethrol may interfere with the vaccination vaccine Phenytoin, phenobarbital, rifampicin and hypokalemic diuretics may reduce the effectiveness of methylprednisolone Methylprednisolone may increase blood glucose due to Therefore, it is necessary to use a higher dose of insulin. Tomethro is only used when prescribed by a doctor, avoiding arbitrary drug use that will adversely affect health. When experiencing any unusual symptoms suspected to be caused by Tomethro, it is necessary to notify the doctor.
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