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Rofba is a primary antihypertensive agent used in patients uncontrolled by monotherapy. Rofba is taken orally as a film-coated tablet. Dosage & usage as well as necessary information of Rofba drug will be in the article below.1. What is Rofba?
Rofba is a drug for the treatment of primary hypertension in patients who cannot be treated and controlled with monotherapy.Prepared in the form of film-coated tablets, Rofba is packaged in 10 tablets of 1 blister, 1 box of Rofba includes 3 blisters.
About the active ingredients in 1 Rofba tablet as follows
Perindopril tertbutylamine 4mg Indapamide 1.25mg
2. Uses of the drug Rofba
The antihypertensive effect of Rofba is due to 2 main active ingredients, Perindopril and Indapamide. Perindopril belongs to the class of angiotensin converting enzyme inhibitors I to II. With the failure to metabolize Angiotensin I → Angiotensin II, the patient will not have vasoconstriction and will not be stimulated to secrete Aldosterone in the adrenal cortex. With Perindopril in Rofba can lower blood pressure without causing salt and water retention, reflex increase in heart rate if used for a long time. In the situation of abrupt discontinuation of Rofba, the patient's blood pressure remains stable and does not relapse or spike again.In patients treated with Rofba, the effectiveness of the drug was shown when a decrease in systolic and diastolic blood pressure was observed in the lying and standing positions.
The active ingredient Indapamide in Rofba has an indole-based diuretic effect and is not in the thiazide group. The diuretic effect of Indapamide by increasing the excretion of NaCl and water, inhibiting the reabsorption of sodium ions in the distal tubule of the renal cortex, so that the patient's body does not fall into a state of salt retention.
Regarding the antihypertensive effect of Indapamide, based on the extrarenal mechanism. Specifically, indapamide has the effect of increasing the response of blood vessels to vasoconstrictor amines to normal, thereby reducing peripheral arterial resistance.
3. Indications for taking Rofba
Rofba is used in the case of patients with primary hypertension and uncontrolled with monotherapy.
4. Contraindications to taking Rofba
Some contraindications to using Rofba drug should be noted as follows
Patients with hypersensitivity, hypersensitivity to any ingredient of Rofba drug Patients with a history of Quincke edema Patients with untreated decompensated heart failure Patients Severe kidney failure, liver failure Patients with hypokalemia Women during pregnancy & lactation. If you are using Lithium, do not use in combination with Rofba
5. Dosage & how to use Rofba
Standard dosage for people with primary hypertension: 1 Rofba tablet/day, taken in the morning before breakfast.
In other cases, use the drug according to the doctor's prescription.
6. Side effects of the drug Rofba
Side effects when using drugs are possible with all drugs. With Rofba drug, the following side effects that patients may experience when using
Effects on the nervous system: asthenia, headache, dizziness, dizziness, drowsiness, sleep disturbance Effects on the digestive system Chemical: Nausea, loss of appetite, dry mouth Effects on cardiovascular system (rare): Orthostatic hypotension, tachycardia Whole body: Fatigue, lethargy, cramps, hypotension stand.
7. Notes when using Rofba
Especially when used concurrently with potassium salts, potassium-sparing diuretics, other antihypertensive drugs. When a dose of Rofba is forgotten, take the next dose as soon as possible and skip the previous dose. Do not take a double dose of Rofba . Rofba drug side effects affect the nervous system, so it is not recommended for people to operate vehicles and machines. During the course of taking Rofba, if blood pressure spikes, the drug should be stopped and reported to a specialist. Rofba is a drug used to treat primary hypertension with 2 main active ingredients: Perindopril tertbutylamine and Indapamide. The drug is prepared in the form of film-coated tablets and used as prescribed by the doctor.
