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Koact 1.2 is a drug belonging to the group of antibiotics against infections, with a broad antibacterial spectrum. Koact 1.2 is used to treat many different infections. Uses, doses and how to use Koact 1.2 will be in the article below.
1. What is Koact 1.2?
Koact 1.2 is an antibiotic used in the treatment of infections of the upper and lower respiratory tract, skin, soft tissue, urinary tract, and genitals. The drug is used in the form of injection / intravenous infusion with the main active ingredient being Amoxicillin Sodium at a dose of up to 1000mg and Clavulanic Acid with a concentration of 200mg.
The drug is manufactured and packaged in a vial of powder for injection.
2. Uses of Koact 1.2
Amoxicillin in Koact 1.2 is a broad-spectrum Penicillin group of antibiotics, used to treat some infections caused by bacteria. The advantage of Koact 1.2 comes from the fact that Amoxicillin is very stable in the stomach environment in the presence of gastric acid. Absorption of the drug is not affected by food, milk, on the contrary, it occurs quickly and safely.
Koact 1.2 distributes rapidly into body fluids, with the exception of brain tissue and cerebrospinal fluid. Regarding elimination, approximately 60% of an oral dose of amoxicillin is excreted in the urine within 6-8 hours. The half-life of the drug Koact 1.2 is 1 hour, this time is longer in neonates and the elderly, with renal failure, the half-life of the drug can be up to 20 hours.
3. Indications for taking Koact 1.2
The following medical conditions are indicated to use Koact 1.2
Upper respiratory tract infections: tonsillitis, sinusitis, acute otitis media. Lower respiratory tract infections: Chronic bronchitis, lobar pneumonia Urinary tract infections:: Pyelonephritis, gonorrhea, obstetric infections. Prophylaxis of endocarditis, prevention of infection in gastric surgery, head and neck surgery
4. Contraindications to Koact 1.2
Some cases where the use of Koact is not indicated:
Patients have previously had hypersensitivity reactions to beta-lactam antibiotics (penicillins, cephalosporins). Patients with severe liver and kidney failure. Patients with peptic ulcer disease. Patients with liver failure due to taking penicillin. The patient is in mononucleosis.
5. Dosage and how to use Koact 1.2
Koact 1.2 is a drug used by injection or intravenous infusion, absolutely do not drink.
Dosage for adults and children over 12 years old: 1.2g / time / 8 hours, if severe condition can be used every 6 hours. The maximum daily dose is 7.2g, maximum 1.2g per day (1 vial of Koact 1.2 powder for injection). Children 3 months to 12 years old: 30mg / kg / time / 8 hours, if severe can use Koact 1.2 every 6 hours / time. Children 7 days to 3 months: 30mg/kg/time/ 8 hours. Children 0-7 days: 30mg/kg/time/12 hours. Prophylaxis in surgery 1.2g under anesthesia, if surgery is prolonged, use 1.2g/dose, use 3-4 doses within 24 hours Koact 1.2 dose for patients with renal failure: ClCr index = 10 - 30mL/ min: 1.2g initially, then 600mg/time/12 hours; if ClCr < 10mL/min: start at 1.2g, then 600mg/time/24 hours.
6. Koact 1.2 side effects
As a drug with a fairly high concentration of Amoxicillin antibiotic with clavulanic acid, Koact 1.2 also comes with many side effects that have been recorded in patients. Side effects include:
Hypersensitivity reactions: Pruritus, skin rash, urticaria, Stevens Johnson syndrome. Hepatic effects: hepatitis, jaundice, cholestasis (rare). Effects on circulation masuL: Decrease in white blood cells/platelets, prolong bleeding time and prothrombin. Effects on the central nervous system: Hyperactivity, convulsions (rare), usually only at high doses.
7. Notes when using Koact 1.2
Use caution when using Koact 1.2 in patients with liver dysfunction. Pay attention to sodium levels in patients on sodium restriction, especially when taking Koact 1.2 as an IV infusion. Long-term use of Koact 1.2 may lead to superinfection with non-susceptible microorganisms. Koact 1.2 is an antibiotic with ingredients Amoxicillin and clavulanic acid, a broad-spectrum antibacterial drug, and is used in the prevention and treatment of mild to severe infections. The drug is administered by injection and intravenous infusion, so patients need to strictly follow the doctor's prescription to achieve the best effect.
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