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Rifampicin 300mg is a semi-synthetic antibiotic of the Rifamycin family, with bactericidal activity against strains of Mycobacterium and gram-positive bacteria. In addition, Rifampicin is also active against gram-negative bacteria at higher doses.
1. What is Rifampicin 300mg?
Rifampicin 300mg drug belongs to the group of drugs to treat parasites, anti-infectives, antivirals and fungi. The drug is prepared in the form of capsules, manufactured by the Mekophar Pharmaceutical Joint Stock Company - Vietnam.
2. What are the uses of Rifampicin 300mg?
The mechanism of action of the active ingredient Rifampicin in the drug is to prevent the biosynthesis of bacterial nucleic acids by inhibiting RNA polymerase through the formation of a stable drug–enzyme complex.
The drug is rapidly absorbed from the gastrointestinal tract, with the influence of food on drug metabolism.
Rifampicin 300mg is distributed into tissues and body fluids, metabolised in the liver and eliminated via bile, feces and urine.
Rifampicin 300mg is indicated in the following cases:
Treatment of tuberculosis, leprosy and severe infections caused by susceptible gram-positive and gram-negative bacteria. Support for the prophylaxis of meningitis caused by Haemophilus influenzae, Neisseria meningitidis. Treatment of Brucella disease.
3. Dosage and how to use Rifampicin 300mg
Dosage and way of taking Rifampicin 300mg depends on each disease and different subjects. Specifically:
With tuberculosis: Adults take 8-12 mg/kg, once a day, away from meals. Children take 10mg/kg, once a day. Drink away from meals. Note: When used in combination with other anti-tuberculosis drugs, follow the doctor's instructions. For infections caused by Gram-positive and Gram-negative bacteria: Newborns: 15-20mg/kg/day, divided into 2 times. Adults: 20 - 30mg/kg/day, divided into 2 times. Drink away from meals. With Brucella: Use a combination of Rifampicin 300mg/day, take 1 time in the morning on an empty stomach and Doxycycline 200mg/day, take it once in the evening. If the disease is acute, the course of treatment is 45 days. Prophylaxis of meningococcal meningitis : Adults take a dose of 600mg / time, 12 hours apart. Children 1 month - 12 months old dose 10mg/kg, 12 hours apart. Children under 1 month old dose 5mg/kg every 12 hours orally. Drink away from meals. With leprosy: Take 600mg/time/month. Use in combination with other anti-leprosy drugs and as directed by your doctor. Note: The dose of Rifampicin 300mg above is for reference only. The specific dose depends on the patient's condition, subject, and disease progression. To ensure safe, accurate and appropriate dosing, you should consult your doctor or healthcare professional.
4. Contraindicated drug Rifampicin 300mg.
The drug Rifampicin 300mg should not be used in the following cases:
Patients who are sensitive to Rifamycin group antibiotics or any of the ingredients in the drug. Patients with porphyria metabolic disorders. Severe impairment of liver function.
5. Drug interactions Rifampicin 300mg.
During the use of Rifampicin 300mg you may encounter the following interactions:
Calcium blockers, antifungals: Cyclosporin, Tacrolimus, Corticoids, Estrogen... Isoniazid (INH) and Pyrazinamide ingredients will increase toxicity with liver. Interacts with Enzyme cytochrome P450, increases metabolism of drugs: Oral contraceptives, anticoagulants, Digoxin, Letoconazole, Erythromycin, Clarithromycin, Diazepam, beta blockers,... Antacids, Bentonite, Clofazimine,. .. Some of these drugs when taken together will reduce the absorption of Rifampicin. Therefore, they need to be taken separately, should be taken 8-12 hours apart.
6. Rifampicin 300mg side effects.
Common side effects:
Urine, stools and tears are orange red; Mild digestive disorders; Hypersensitivity: Itching, rash. Less common side effects:
Fatigue; Headache; Jaundice; Increase liver enzymes.
7. What to do when overdosing or forgetting a dose of Rifampicin 300mg
If an overdose of Rifampicin 300mg occurs, the patient should immediately go to the nearest medical facility so that the medical professional can have a timely treatment plan. If you accidentally forget a dose, take it as soon as possible. However, if the missed dose is close to the next dose, skip the missed dose and take your next dose at the scheduled time. You should not take twice the prescribed dose.
8. Notes in the process of taking Rifampicin 300mg
Need to read the instructions for use carefully before taking the drug and strictly follow the doctor's dosage instructions. During treatment with Rifampicin 300mg, it is necessary to conduct periodic blood tests and liver function tests. Rifampicin 300mg should not be used in pregnant women in the last 3 months of pregnancy, because of possible bleeding due to decreased prothrombin. Because of this, Rifampicin should only be used when the benefits are weighed against the possible risks to the fetus. Rifampicin is excreted in breast milk and poses no risk to the infant. Above is useful information about the drug Rifampicin 300mg. During the course of taking the medicine, if you have any questions, please immediately contact your doctor or pharmacist, medical professional for answers.
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