Uses of Rezol 20

This is an automatically translated article.

1. What is Rezol 20?

Rezol 20 is manufactured by Hyrio Laboratories Pvt. Ltd (India). The main ingredient of Rezol is Rabeprazole 20ng, belongs to the group of gastric proton pump inhibitors, so it is used to treat peptic ulcers, gastroesophageal reflux disease (GERD) and Zollinger's syndrome. - Ellison.
Rezol 20 is prepared in the form of enteric coated tablets, each box contains 1 blister x 10 tablets, corresponding to each tablet contains 20mg Rabeprazole.

2. Indications of the drug Rezol 20

Rezol 20 products are indicated for the treatment of the following cases:
Peptic ulcer; Gastroesophageal reflux disease (GERD); Zollinger-Ellison syndrome. Rabeprazole in Rezol belongs to the group of active ingredients against gastric acid secretion through proton pump inhibitor mechanism. Rezol 20 does not exhibit antihistaminic H2 receptor antagonist or anticholinergic properties, instead the antisecretory effect is due to inhibition of the H+/K+ATPase enzyme on the surface of gastric parietal cells. This enzyme is considered an acid pump (also known as a proton pump), so Rabeprazole is classified as a gastric proton pump inhibitor.
Rezol 20 prevents the final stage of gastric secretion in the stomach. In the parietal cells of the stomach, the active substance Rabeprazole receives an additional proton, which then accumulates and is converted to the active sulfenamide.
Pharmacokinetics of Rezol 20:
Absorption: After taking 1 tablet of Rezol 20, Rabeprazole is absorbed and can be found in plasma after 1 hour. The absolute bioavailability of a 20 mg oral dose of Rabeprazole compared with intravenous administration is approximately 52%, in addition, the effect of food on the absorption of Rezol 20 has not been evaluated; Distribution: Approximately 96.3% of a dose of Rezol 20 is bound to plasma proteins; Metabolism: Rabeprazole in Rezol 20 is extensively metabolized in the body. The main metabolites are Thioether and Sulphon with no antisecretory activity. In vitro studies have shown that Rabeprazole is metabolized primarily in the liver by the cytochrome P450 enzymes CYP3A and CYP2C19; Elimination: After taking 1 tablet of Rezol 20, about 90% of the drug is excreted in the urine, the remainder recovered in the feces (as metabolites). At the same time, no active ingredient Rabeprazole was recorded in the original form, excreted in the urine or feces.

3. Dosage of the drug Rezol 20

Rezol 20 tablets are for oral use, patients need to swallow the whole tablet, do not crush, break or chew. Rezol can be taken on an empty stomach or on an empty stomach.
Specific dosage of Rabeprazole is as follows:
Gastroesophageal reflux disease (GERD): The recommended adult dose is 20mg (equivalent to 1 Rezol 20 tablet) daily for 4-8 weeks and lasts for 4 to 8 weeks. an additional 8 weeks if symptoms do not improve; Heartburn due to GERD: The recommended dose is 20mg per day (1 Rezol 20 tablet) taken for 4 weeks and can be taken for an additional 4 weeks if symptoms do not improve; Gastric - duodenal ulcer: The recommended dose is 20mg orally daily for 4 weeks; Zollinger - Ellison syndrome: The starting dose for adults is 60mg per day (corresponding to 3 pills of Rezol 20 ), then adjust according to the patient's improvement in symptoms. Alternatively, doses of 100mg daily and 60mg twice daily may be used; Helicobacter pylori eradication regimen includes Rezol 20, Clarithromycin 500mg, Amoxicillin 1000mg x 2 times/day (morning and afternoon) for 7 days. Dosage of Rezol 20 above is for reference only. Specific dosage depends on each patient with specific condition and progression. Patients should consult and follow the doctor's instructions to get the most appropriate dose.
Overdosage of Rezol 20 and its management:
Currently, there are no reports of Rabeprazole overdose; In case the patient takes too much Rezol, leading to coma or respiratory failure, contact 911 immediately. Missed dose of Rezol 20 :
Patients should add the missed dose as soon as they remember. If it is almost time for your next dose, skip the missed dose and continue with your normal dosing schedule; Note that the patient should not take Rezol 20 with a double dose to make up for the missed dose.

4. Side effects of the drug Rezol 20

There have been reports of undesirable effects in about 1% of patients treated with Rabeprazole in Rezol 20 such as:
Headache, dizziness; loose stools or constipation, abdominal pain, nausea, vomiting; Rash; A cough; Weakness, back pain; Flatulence; Fever, body aches with fatigue, malaise, abdominal distension; Angina , increased or decreased heart rate , palpitations , palpitations , increased blood pressure , peripheral edema ; Liver abnormalities, including liver failure (rare), increased ALT (SGPT), increased AST (SGOT), increased Alkaline Phosphatase, increased bilirubin (jaundice); Anorexia, colon irritation, stool discoloration; Candidiasis of the esophagus, atrophy of the mucous membrane of the tongue, dry mouth; Hypoglycemia, weight gain; Cramps, muscle pain, joint pain, leg pain; Psychological disorders including depression, impatience, hallucinations, confusion, insomnia, restlessness, tremors, lethargy, daydreaming, anxiety, abnormal dreams; Nosebleeds, sore throat; Dermatitis, rash, angioedema, urticaria, pruritus; Hair loss, dry skin, hyperhidrosis; Tinnitus, strange taste in the mouth; Urinary tract infection, purulent urine, increased frequency of clear urine; Increased serum creatinine, proteinuria, urine sugar; Gynecomastia in male patients; Agranulocytosis has been observed in male patients over 65 years of age with diabetes who have received multiple drugs with Rezol 20. The relationship between Rabeprazole and agranulocytosis is unclear; Pancytopenia, decreased platelet count, neutrophil count, hemolytic anemia. When experiencing side effects of Rezol 20, patients should stop using and notify their doctor or quickly go to the nearest medical facility for timely treatment.

5. Some notes when using Rezol 20

Before using Rezol, patients should carefully read the instructions for use and consult a doctor and pharmacist.
Rezol 20 products are contraindicated for the following cases:
People with hypersensitivity to Rabeprazole or any component of Rezol 20; Women during pregnancy; Breastfeeding mothers; Children. Some cautions when using Rezol 20:
It is necessary to exclude certain malignancies in patients with peptic ulcer before starting treatment with Rezol 20 because Rabeprazole may obscure clinical symptoms. and cause delay in the diagnosis of cancer pathology; Limit long-term treatment with Rezol 20, except in patients with Zollinger-Ellison syndrome; Rezol 20 does not affect the ability to drive and use machines.

6. Drug interactions of Rezol 20

Patients should be careful when taking Rezol 20 with the following drugs:
Digoxin: Digoxin blood levels may increase due to increased absorption of digoxin when gastric pH increases; Antacids containing aluminum hydroxide or magnesium hydroxide: There have been reports that the mean serum AUC of rabeprazole decreased by 8% after co-administration of Rezol 20 and 6% with Rezol 20 1 hour after administration of Antacids. compared with the use of Rezol 20 alone. Rezol 20 has the main ingredient of Rezol drug, which is the active ingredient Rabeprazole 20ng, belongs to the group of gastric proton pump inhibitors, so it is used to treat peptic ulcers, gastroesophageal reflux disease (GERD) and gastroesophageal reflux disease (GERD). Zollinger-Ellison syndrome. To ensure effective treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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