This is an automatically translated article.
Protevir 300mg medicine has the main ingredient is Tenofovir disoproxil fumarate. The drug is used to treat chronic hepatitis B in adults, in combination with antiretroviral drugs in the treatment of HIV.
1. Uses of the drug Protevir
What is Protevir? This is a drug made in the form of film-coated tablets, the composition includes Tenofovir Disoproxil Fumarate 300mg and excipients just enough. Oral drug, indicated for the following cases:
Treatment of chronic hepatitis B in adults with compensated liver disease, evidence of viral replication, histological evidence of inflammation or fibrosis; Combination with other antiretroviral drugs in the treatment of HIV patients: In combination with other antiretroviral drugs in the treatment of HIV - type 1 in adults; In combination with other antiretroviral agents for the prevention of post-exposure HIV infection in individuals at risk of viral infection. Protevir 300mg drug should not be used in case the patient is sensitive to tenofovir or other ingredients in the drug.
Thuốc Protevir được sử dụng để điều trị viêm gan B mạn tính
2. How to use and dose Protevir
2.1. How to use Protevir drug need to drink whole tablet with a sufficient amount of water; Do not break, chew, or crush the tablet. The drug should be taken after a full meal.
2.2. Dosage Dosage for chronic hepatitis B, depending on specific subjects:
People aged 18 years and over, with normal kidney function: 300mg/time/day; Patients with hepatic impairment : No dose adjustment is required; Renal Impairment: Tenofovir is eliminated by renal excretion. Therefore, tenofovir concentrations are increased in patients with renal impairment. Therefore, it is necessary to adjust the dose for patients with creatinine clearance < 50ml/min as follows: ClCr ≥ 50ml/min: 300mg/24 hours; ClCr 30 - 49ml/min: 300mg/48 hours; ClCt 10 - 29ml/min: 300mg/72 - 96 hours; People on hemodialysis: 300mg/7 days or after the total hemodialysis time is nearly 12 hours; Dosage for HIV patients, depending on specific subjects:
HIV infection: Use a dose of 300mg/time/day, in combination with other antiretroviral drugs; Prophylaxis of HIV infection after occupational exposure: 300mg/time/day in combination with other antiretroviral drugs. Ideally, the drug should be administered within a few hours of exposure, continuing for the next 4 weeks if tolerated; Prophylaxis of non-occupational HIV infection: 300mg once daily in combination with at least 2 other antiretroviral agents. Ideally, the drug should be taken within 72 hours of exposure, continued for 28 days. Dosage is for reference only. The specific dose will be prescribed by the doctor depending on the condition and the progress of the disease.
2.3. Overdose When overdosing, the patient should be treated symptomatically and supportively. Possible symptoms include: Nausea, vomiting, allergic reaction, hypophosphataemia, lactic acidosis, acute renal failure, etc. The patient may need hemodialysis to remove tenofovir. Patients who overdose should call an ambulance or go to the nearest hospital for early examination and treatment.
2.4. Missed dose If a dose of Protevir is missed, the patient should take it as soon as possible. If it is almost time for your next dose, skip the missed dose, take your next dose at the scheduled time, do not take a double dose.
3. Side effects of the drug Protevir
When using Protevir, patients may experience some side effects such as:
Nausea, vomiting, diarrhea, loss of appetite, bloating, indigestion, low blood phosphate levels; Skin rash; Increased liver enzymes, liver disease, hypertriglyceridemia, neutropenia, hyperglycemia, nephritis, renal failure, acute renal failure, Fanconi syndrome,...; Liver lactic acid poisoning, fatty liver, cirrhosis; Peripheral neuropathy, dizziness, headache, somnolence, depression, asthma, dyspnea, muscle pain, profuse sweating. When experiencing side effects of Protevir, patients should stop taking the drug, notify the doctor immediately or immediately go to the nearest hospital for early support.
Thuốc Protevir 300mg có thể khiến người bệnh gặp tình trạng buồn nôn
4. Be careful when using Protevir
Before using Protevir, you should note:
Do not combine the drug with emtricitabine or adefovir dipivoxil; There is a risk of lactic acidosis, severe fatty liver. Although taking this drug has little risk, the patient needs to know about this side effect for timely detection and treatment; Stopping Protevir can make liver disease worse; The efficacy and safety of the drug in patients under 18 years of age have not been established. The drug can cause side effects such as headache, dizziness, somnolence, ... so caution should be exercised when using the drug for people who often drive or operate machinery; Use caution when using Protevir for patients 65 years of age and older; The effect of Protevir on pregnant and lactating women has not been determined, so it is best for these subjects not to use the drug.
5. Protevir drug interactions
Some Protevir drug interactions include:
Do not combine Protevir with other drugs containing tenofovir disoproxil fumarate, didanosine or adefovir dipivoxil; Avoid combining Protevir with drugs that can cause nephrotoxicity; When combining drugs with darunavir/ritonavir, atazanavir/ritonavir, lopinavir/ritonavir: No dose adjustment is required but regular assessment and monitoring of renal function is required; Protevir should be taken on a full stomach because food will increase the bioavailability of tenofovir. Protevir 300mg is a prescription medicine prescribed by a doctor. Patients should pay attention to using the medicine according to the instructions, do not use the expired medicine, show discoloration or wetness. If you experience side effects, you should stop taking the medicine and tell your doctor right away.
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