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Primolut-n is a progestogen containing norethisterone used in the treatment of dysfunctional bleeding, primary or secondary amenorrhea, menstrual regulation, endometriosis, etc. So what are the uses of primolut-n?1. What is primolut-n?
Primolut-N contains norethisterone, which is a potent progestogen. The progestogenic effects of norethisterone in the endometrium help in the treatment of dysmenorrhea, primary and secondary amenorrhea, and endometriosis. Based on those stabilizing effects, Primolut-N may also alter the timing of menstruation.
Norethisteron can inhibit gonadotropin hormone secretion and inhibit ovulation at a dose of 0.5 mg/day. A positive effect in the treatment of premenstrual symptoms can be seen in the suppression of ovarian function. Like progesterone, norethisteron can produce heat and change body temperature.
2. Indications and contraindications
2.1 Indications for the use of primolut-n The use cases of primolut-n include:
Bleeding due to dysfunction (cervical bleeding not due to physical damage) and prevention of recurrence due to disorder dysfunction. Primary and secondary amenorrhea. Before starting treatment, pregnancy and the presence of a prolactin-secreting pituitary tumor should be excluded. The possibility of an increase in the size of macroscopic adenomas cannot be excluded with prolonged high-dose estrogen administration. Premenstrual syndrome, cyclical breast disease. Can alleviate premenstrual symptoms such as headache, water retention, breast engorgement... Menstruation: Can delay monthly menstrual bleeding with Primolut-N. However, use only for people who are not at risk of pregnancy during treatment. Endometriosis disease. In addition to the above uses, primolut-n may also be used to treat some other conditions that are not listed above. Therefore, before taking the drug, consult your doctor for advice and effective use of the drug.
2.2 Contraindications to the use of primolut-n The cases of contraindications to the use of primolut-n include:
Pregnant or suspected pregnant women and lactating women. Progressive venous thromboembolism. High risk of arterial or venous thrombosis. History or current of: Arterial or cardiovascular disease (eg, myocardial infarction, cerebrovascular accident, myocardial ischemia). Prognostic signs of thrombosis (eg, transient ischemic attack, angina). Thrombotic events, arterial or venous thromboembolism (eg, deep vein thrombosis, pulmonary embolism, myocardial infarction) or cerebrovascular accident. Severe liver disease or liver function parameters have not returned to normal. Liver tumors (benign or malignant). History of migraine with focal neurological signs. Diabetes is associated with cardiovascular diseases. Presence or suspicion of sex hormone-dependent tumors. Hypersensitivity to any of the ingredients of the drug.
3. Usage and dosage of primolut-n
Primolut-n is made in tablet form so it can be taken on an empty stomach or on an empty stomach. You should take the medicine with a full glass of water to avoid stomach irritation. The dose of primolut-n drug will depend on the disease status and age of the patient such as:
Hemorrhage due to dysfunction: 1 tablet/time x 3 times/day, for 10 days. Prevention of relapse due to dysfunction: Take prophylaxis 1 tablet/time, 1-2 times/day, from day 16 to day 25 of the cycle. Primary and secondary amenorrhea: Estrogen supplementation (14 days) is required prior to initiating treatment with Primolut-N. Then take 1 tablet / time, 1-2 times / day, for 10 days. Once endogenous estrogen is produced, stop estrogen to induce menstrual bleeding by taking 1 Primolut-N tablet twice a day from day 16 to day 25 of the cycle. Premenstrual syndrome, breast disease: Take 1 capsule/time, 1-3 times a day. Menstrual cycle: Take 1 capsule/time, 2-3 times/day, no more than 10-14 days, starting 3 days before expected period. Endometriosis: Start treatment on day 1 to day 5 of the cycle, 1 tablet / time, 2 times / day, if there is little bleeding, increase 2 tablets / time, 2 times / day and can Return to initial dose when bleeding stops. Treatment for at least 4-6 months. During the treatment period, there is no ovulation and no menstruation. Use primolut-n regularly to get the most benefit from it. To take your medicine safely, take primolut-n exactly as directed by your doctor, and do not use it more often, less often, or for longer than prescribed. Absolutely do not abuse the drug for too long for a long time or arbitrarily increase the dose of the drug. Because this not only makes the condition worse, but also increases the risk of unwanted effects.
4. Undesirable effects when using primolut-n
Some unwanted effects that may occur when using primolut-n include:
Reproductive system and mammary gland disorders: Abnormal uterine/vaginal bleeding including spotting, lack of menstruation , amenorrhea (in endometriosis indications). Skin: Rash, rash Nervous: headache, migraine Eyes: visual disturbances Respiratory: difficulty breathing Digestion: nausea Before prescribing a drug, the doctor always considers the benefits and effectiveness of the drug. primolut-n carries a greater risk of side effects. However, in some cases, when taking primolut-n, unwanted effects may still occur. Therefore, when there are unusual signs after taking the drug, especially when a severe allergic reaction occurs with accompanying signs such as difficulty breathing, severe dizziness, swelling, rash or itching of the face, throat, tongue,... In this case, the patient should immediately notify the medical staff for immediate intervention.
5. Some notes when using primolut-n
Some precautions when using primolut-n include:
Tell your doctor about any history of allergy to primolut-n or any other allergies. Primolut-n may contain ingredients that are inactive and could cause allergic reactions or other serious problems. Report any medications you are taking including prescription and nonprescription drugs, herbs and supplements, foods, dyes or preservatives. Light bleeding during the dosing period after the end of the first bleeding cycle. Do not take a break or stop taking the medicine. About 2 - 4 days after the end of treatment, bleeding due to drug discontinuation will occur, similar to normal menstruation, in extent and duration. Prolonged, severe bleeding: If the medication continues to be taken regularly without stopping bleeding, it may be due to physical damage or exogenous factors (such as polyps, carcinoma in the high position of the cervix). or endometriosis, fibroids, placental abruption, ectopic pregnancy, or coagulopathy). Other measures are needed. The same is true for the case where the first bleeding has stopped, and a rather heavy bleeding occurs while taking the drug. Primolut-n should be used with caution in patients with risk factors for venous thromboembolic events (personal or family history, age, obesity, prolonged immobilization, major surgery or surgery). trauma), the risk increases during childbearing years. Tumor: Monitor for benign (very rare malignant) liver tumors. Notify immediately if you have severe upper abdominal pain, enlarged liver or signs of bleeding in the abdomen. If you forget to take a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue taking the medicine as scheduled. Do not arbitrarily use the drug twice the dose more than the treatment regimen. Using an overdose of primolut-n can cause serious symptoms such as nausea, vomiting, abdominal pain, weakness,...
6. Drug interactions
Drug interactions may reduce the effect of primolut-n, or increase the effect of unwanted effects. Tell your doctor about all other medicines you are taking including vitamins, over-the-counter medicines, prescription drugs, and herbal products. Do not stop, start, or change the dose of any medicine without your doctor's consent without your doctor's consent.
Some drugs that can interact with primolut-n include:
Long-term treatment with drugs that affect liver enzymes (phenytoin, barbiturates, primidone, carbamazepine, rifampicin, oxcarbazepine, rifabutin,...) increased clearance of Primolut-N, reducing the therapeutic effect. Interactions with metabolites of certain other drugs (eg, Cyclosporin). Primolut-N may affect the results of laboratory tests such as: biochemical indices of the liver, thyroid, adrenal gland and kidney function, the concentration of proteins in the plasma such as corticosteroids-binding globulin, Lipid/Lipoprotein , carbohydrate metabolism index, coagulation/bleeding index. These changes are usually within allowable limits.
7. How to store primolut-n
Store primolut-n at room temperature, away from light and away from moisture. Do not store primolut-n in a humid place or in the freezer. Different medicines will have different storage methods, so read the primolut-n storage instructions on the package carefully, or ask your pharmacist. Keep primolut-n out of the reach of children and household pets. When the medicine has been damaged and cannot be used anymore or has expired, dispose of the medicine according to the correct procedure. Do not dispose of primolut-n into an environment such as a water pipe or toilet unless requested to do so. Consult your waste disposal company or pharmacist for more information on how to safely dispose of primolut-n to help protect the environment.
In summary, primolut-n is a progestogen containing norethisterone used in the treatment of dysfunctional bleeding, primary or secondary amenorrhea, menstrual regulation, and endometriosis. ,... However, primolut n can cause some unwanted effects and drug interactions, so tell your doctor what medicines you are taking to reduce your risk of side effects and co-administration. while increasing the effectiveness of the treatment.
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