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Predrithalon is one of the drugs containing Dexamethasone that is used quite commonly in prescription treatment today. So what is Predrithalon? What are the effects of Predrithalon and how should it be used safely and effectively for patients?
1. What is Predrithalon?
Predrithalon is a drug that belongs to a group of drugs that treat hormonal and hormonal problems. The main ingredient of Predrithalon medicine contains Dexamethasone acetate 0.5mg.
Dexamethasone acetate is a water-insoluble synthetic glucocorticoid.
The drug is well absorbed from the gastrointestinal tract and used topically. When entering the body, the drug is absorbed mainly in the liver, kidneys, and adrenal glands and then excreted in the urine in the form of unconjugated steroids.
Dexamethasone has 30 times stronger anti-inflammatory effects than Hydrocortisone, has immunosuppressive, anti-allergic, and sometimes also helps to balance electrolytes.
There are many different uses of Dexamethasone, including oral, intramuscular, inhaled, and topical forms. Depending on the purpose of treatment of each disease, there are different types of drugs.
Dexamethasone is indicated for the treatment of some diseases such as bacterial infections, cerebral edema caused by brain tumors, diseases related to joints, especially arthritis, shock due to excessive bleeding, shock due to trauma or surgery. ..
2. What are the effects of Predrithalon?
Predrithalon has anti-inflammatory effects, can suppress immunity, so it is applied in the treatment of some diseases related to immune factors such as arthritis, skin diseases ...
Predrithalon is indicated for use with the following cases:
Used in non-specific steroid therapy and the patient needs to be treated aggressively. Specifically, in severe allergic disease, treatment of asthma, laryngitis, or reactions occurring after blood transfusion. Predrithalon is indicated for use in combination with other drugs for the treatment of cerebral edema or in patients with shock of various etiologies. To promote fetal maturation, dexamethasone can be given before birth, especially during preterm labour, usually between 24 and 34 weeks of pregnancy. In addition, the drug is also used as an adjuvant therapy in the treatment of connective tissue inflammation and meningitis caused by pneumococcal disease. Contraindications to use Predrithalon in:
People with a history of allergy or hypersensitivity to any of the ingredients of the drug. The patient has a systemic fungal infection. Patients with tuberculosis, gonorrhea or viral infections that have not controlled their medical conditions as well as their symptoms. Cases with severe joint damage. Particular attention should be paid to patients with peptic ulcer disease, diabetes or hypertension.
3. How to use Predrithalon?
3.1. Dosage and administration Predrithalon is produced in the form of hard capsules, usually packaged in bottles, each bottle has 200 pills. Predrithalon is taken by mouth, should be divided into small doses throughout the day and taken at intervals between meals.
Specific drug dose:
For adults: starting dose of 0.75mg to 9mg/day divided into 2 to 4 doses a day depending on the patient's condition. For children: calculate dose according to body weight, take 0.024mg - 0.34mg/kg/day; or calculate the dose by area 0.66mg - 10mg/m2/day, the dose should be divided into 4 times/day. Note:
If using a low dose of less than 1.5 mg/day, it can be given to the patient once a day in the morning. If the patient uses a high dose of more than 1.5 mg/day, it should be divided into 2 to 4 doses/day for maximum absorption and the best therapeutic effect. 3.2. Predrithalon side effects Predrithalon is a drug with relatively many side effects, especially long-term use with high doses can cause many health risks. Some possible undesirable effects of Predrithalon include:
Digestive disorders leading to esophagitis, bloating, acute pancreatitis, peptic ulcer, severe may cause bleeding bleeding or perforation of the stomach; some people have acute pancreatitis, ulceration of the small intestine. Metabolic and endocrine disorders, commonly Cushing's syndrome, decreased glucose tolerance, atrophy of the adrenal cortex leading to the cessation of ACTH hormone secretion, increased risk of diabetes, menstrual disorders, signs and symptoms. Hirsutism, children may have a halt in body growth. Electrolyte disturbances cause salt and water retention, alkaline blood, or hypokalemia. Some other patients have musculoskeletal disorders such as muscle weakness, muscle atrophy, osteoporosis, poor musculoskeletal recovery. In addition, patients may experience skin problems such as skin atrophy, slow healing of lesions, slow healing of scars, appearance of acne, purpura... 3.3. Notes when using Predrithalon To limit the risk of side effects of the drug that affect health, when using Predrithalon medicine, it is necessary to note a few things as follows:
Use the drug exactly as directed by the doctor , do not arbitrarily change the dosage of the drug without consulting specialists and people with medical expertise. For patients requiring long-term treatment with Predrithalon, it should be maintained at the lowest possible dose that still achieves a therapeutic effect, should not be used as a main treatment drug but only as a adjunct to other treatments. Do not discontinue the drug abruptly, the dose should be gradually reduced until the function of the hypothalamic, pituitary, and adrenal axis is stabilized. For pregnant women, the drug can reduce the weight of the fetus and the weight of the placenta, on the other hand, Predrithalon also causes adrenal suppression in the newborn if the mother uses the drug for a long time during pregnancy. Therefore, the drug should not be used in pregnant women. Some studies have shown that Predrithalon may pass into breast milk and affect a nursing infant. Therefore, it is not recommended to use the drug for women who are breastfeeding. If you miss a dose, take it as soon as you remember, do not take a double dose to make up for the missed dose. In case of overdose, contact a specialist or go to the nearest medical facility for timely assistance. Store the medicine in accordance with the manufacturer's instructions, do not use the medicine after the expiration date. Predrithalon has a relatively broad treatment indication in terms of disease, so it has been used quite a lot in clinical practice. However, the drug also has many different side effects depending on the patient's condition as well as the dose used. Please consult your doctor before taking the drug to avoid health effects.
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