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Predmesol medicine with the main ingredient is Methylprednisolone 4mg. This drug is often indicated in the treatment of abnormal adrenal cortex function, allergic airway inflammation, atopic dermatitis, rheumatoid arthritis, .... Let's find out more specifically about the drug's use. Predmesol and how to use, dose in the following article.
1. What is Predmesol 4mg?
Predmesol is manufactured by Ha Tay Pharmaceutical Joint Stock Company - Vietnam. This drug belongs to the group of drugs for pain relievers, antipyretics, non-steroidal anti-inflammatory drugs, drugs for the treatment of gout and osteoarthritis. With the main ingredient is Methylprednisolone 4mg, Predmesol drug is indicated in the treatment of renal cortical dysfunction, rheumatoid arthritis, arthritis, rheumatism, allergic airway inflammation, atopic dermatitis, lupus erythematosus ,....
Predmesol drug is prepared in the form of tablets with 2 concentrations of Predmesol 4mg and Predmesol 16mg, packed in a box of 5 blisters, 10 blisters x 10 tablets.
2. Uses of the drug Predmesol
The Methylprednisolone acetate component in Predmesol has the general properties of the glucocorticoid prednisolone but is less soluble and more difficult to metabolize. Therefore, the drug has a longer-lasting anti-inflammatory and immunosuppressive effect.
2.1. Indications Predmesol is usually used to indicate treatment in the following cases:
Abnormal, unstable adrenal cortex function. Allergic airway inflammation, atopic dermatitis, lupus erythematosus. Arthritis, Rheumatoid Arthritis and Rheumatoid Arthritis. Blood diseases, hemolysis, anemia, granulocytopenia Bronchial asthma, severe allergic diseases including anaphylaxis, ulcerative colitis. In the treatment of cancer: lymphoma, acute leukemia, prostate cancer, breast cancer. Primary kidney failure. 2.2.Contraindications Predmesol is contraindicated for the following cases:
People with fungal infections. The patient has an infection but has not received anti-infective therapy. Hypersensitivity to the components of the drug. Administer live or live attenuated vaccines while receiving immunosuppressive doses of corticosteroids.
3. Usage – Dosage of Predmesol
Uses of Predmesol to help anti-inflammatory and immunosuppressive effectively if used correctly, in the right dosage as follows:
3.1 How to use Predmesol is made in the form of tablets, so it should be taken orally. Patients should take the drug after meals or with food, with milk to help reduce the side effects of the drug on the gastrointestinal tract.
3.2.Dose Depending on the disease, the progression of the disease, the subjects used, the dose is different, and the dose is adjusted accordingly. Below is a reference dose for each patient and disease as follows:
Adults:
Starting dose is from 4 - 48mg/day, use single dose or divided dose depending on each disease:
Multiple sclerosis Oral waste 160mg/day and 1 week, followed by 64mg at a dose of 2 days/1 time, taken within 1 month. Rheumatoid Arthritis: The starting dose is 4-6mg/day. Acute episodes take 16-32 mg/day, then rapidly decrease. Severe rheumatic diseases: Take 0.8mg/kg/day divided into small doses, then take a single dose daily. Acute asthma attack: Take 32-48mg/day for 5 days. Once the attack is over, the dose is gradually reduced. Chronic ulcerative colitis: For mild disease, it is 80mg, in severe cases, 8-24mg/day. Primary nephrotic syndrome: Start dose 0.8-1.6mg/kg for 6 weeks, then reduce dose for 6-8 weeks. Immune hemolytic anemia: Take 64mg/day for 3 days, then reduce the dose and must be treated for at least 6-8 weeks. Sarcoid disease: Oral administration of 0.8mg/kg/day reduces the disease. Low maintenance dose 8mg/day. Children:
Adrenal insufficiency 0.117mg/kg in 3 divided doses. For other indications, take 0.417 - 1.67mg/kg divided 3-4 times. Note: The above dosage is for reference only, to have a suitable dose, please consult your doctor, pharmacist or medical professional.
4.Predmesol side effects
Side effects most often occur when taking high doses and long-term Predmesol.
Common side effects: Nervousness excitability, insomnia, indigestion, increased appetite, hirsutism, joint pain, diabetes mellitus, cataracts, nosebleeds. Uncommon side effects: Dizziness, headache, psychosis, convulsions, brain pseudotumor, delirium, hallucinations, mood swings, euphoria, edema, hypertension, skin atrophy, bruising skin, acne, skin pigmentation, Cushing's syndrome, growth retardation, glucose intolerance, alkalosis, hypokalemia, amenorrhea, hyperglycemia, peptic ulcer, abdominal distention, nausea, vomiting, esophagitis, pancreatitis, muscle weakness, osteoporosis, bone fractures,...
5. Predmesol drug interactions
Methylprednisolone is an inducer of the cytochrome P450 enzyme and a substrate of the P450 3A enzyme. Therefore, the drug affects the metabolism of erythromycin, cyclosporin, phenytoin, phenobarbital, ketoconazole, carbamazepine and rifampicin. Phenobarbital, phenytoin, rifampicin and hypokalemic diuretics may decrease the effectiveness of Predmesol. Methylprednisolone can increase blood sugar so higher insulin doses are needed. In order to avoid drug interactions that affect the effectiveness of Predmesol and the effectiveness of treatment, patients should list and immediately notify the doctor about the medicines they have been taking recently (including prescription drugs). , over-the-counter medicines, herbs and dietary supplements).
6. Precautions when taking Predmesol
Predmesol should be used with caution in patients with osteoporosis, new vascular connections, mental disorders, duodenal ulcers, peptic ulcers, hypertension, diabetes, heart failure, liver failure, and liver failure. kidney, glaucoma, thyroid disease, cataracts. Because of the risk of side effects, the drug should be used with caution in the elderly. High doses of the drug can affect the effectiveness of the vaccine. The drug can cause nervous stimulation, dizziness, headache, and hallucinations. Therefore, the drug should not be used while driving or operating machinery. Prolonged use of Predmesol may affect the weight of the fetus and the drug can pass into breast milk. Therefore, for women who are pregnant or breastfeeding, they should be cautious, carefully weigh the benefits and harms of the drug.
7. Handling missed dose, overdose
If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next scheduled dose. Do not overlap or double the prescribed dose to avoid affecting health.
In case of overdose and unusual symptoms, call 911 or go to the nearest medical facility for timely examination and treatment.
To ensure that the use of Predmesol is not degraded, lost or damaged, you should store the medicine in a dry place with a temperature below 30 degrees. Do not store the medicine in a place with direct sunlight and high humidity. Medicines should be kept out of the reach and reach of children to prevent children from playing and taking the wrong medicine.
Hope this article has helped people know the uses of Predmesol, as well as how to use it, and the appropriate dosage to be effective in treating the disease.
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