This is an automatically translated article.
Neo nidal medicine has the main ingredient Aceclofenac. The drug is indicated for the short-term treatment of pain after trauma, pain after surgery. At the same time, the drug is also effective in the treatment of inflammation or swelling after dental surgery or orthopedic trauma, inflammatory and painful conditions such as rheumatoid arthritis, degenerative arthritis, primary dysmenorrhea, rheumatism. , ankylosing spondylitis.
1. What is Neo nidal drug? Neo-nidal side effects
Neo nidal drug has active ingredients including Aceclofenac and other excipients. This is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. The action of the active ingredient Aceclofenac is as follows:
Active ingredient Aceclofenac strongly inhibits the activity of cyclooxygenase, thereby reducing the formation of prostaglandins, prostacyclin and thromboxane which are mediators of the inflammatory process. The drug has an antagonistic effect on the proteolytic enzyme system and stabilizes the lysosomal membrane, thereby preventing the release of inflammatory chemical mediators. Pharmacokinetics of the drug Neo nidal:
Absorption: Active ingredient Aceclofenac is well absorbed from the gastrointestinal tract, maximum plasma concentrations appear 1 to 3 hours after oral administration. Distribution: more than 99% of Aceclofenac is bound to plasma proteins. Elimination: Approximately 2/3 of an administered dose of Neo nidal is excreted in the urine as hydroxy metabolites. The mean half-life of Neo nidal is 4 hours.
2. Indications of Neo nidal
Neo nidal drug is indicated for use in the treatment of the following diseases:
Treatment of acute and chronic inflammatory diseases such as: primary dysmenorrhea, rheumatism, rheumatoid arthritis, degenerative arthritis, ankylosing spondylitis vertebrae. Treatment of acute pain: toothache, neuralgia, menstrual pain, pain caused by kidney stones,... Anti-inflammatory treatment in trauma and post-surgery cases.
Neo nidal được chỉ định trong điều trị một số tình trạng bệnh lý chấn thương
3. Contraindications of Neo nidal
Absolutely do not use Neo nidal medicine in the following cases:
People who are sensitive or sensitive to any ingredient of the drug. People with a history of asthma, acute rhinitis, bronchospasm. People with duodenal ulcers, or recurrent peptic ulcers. Women who are pregnant in the last trimester of pregnancy. Not for use in children under 15 years of age. Patients with a history of gastrointestinal bleeding caused by the use of drugs of the NSAID class. People with medical conditions such as congestive heart failure, liver failure, severe kidney failure. People with a history of myocardial infarction, peripheral artery disease.
4. Dosage and how to use Neo nidal
4.1. How to use the drug Neo nidal Neo nidal drug is prepared in the form of tablets should be used orally. Swallow the tablet whole with cooled boiled or filtered water. Never chew or break the tablet before taking it. The time to take Neo nidal is during and after eating. While using Neo nidal, avoid using stimulants or alcohol, because of the risk of harmful effects on the body. 4.2. Dosage of Neo nidal drug Depending on different groups of subjects, the dosage is different, you can refer to the dose as follows:
Adults take 20mg/day, divided into 2 times, drink in the morning and evening. Elderly people keep the same dose. Hepatic impairment: reduce the dose for patients with liver failure. The starting dose is 100mg. Renal failure: Refer to the doctor's dosage for more depending on the severity of kidney failure. 4.3. In case of overdose and management of missed dose: In case of missed dose Neo nidal: Take the missed dose as soon as you remember. If the time interval between the missed dose is close to the next dose, skip the missed dose and absolutely do not take 2 doses at the same time. In the event of an overdose of Neo nidal: Acute poisoning with Aceclofenac may occur, manifesting mainly as aggravation of undesirable effects. Symptoms include hypotension, renal failure, seizures, respiratory failure, gastrointestinal irritation. Treatment: immediately notify the doctor and immediately go to the nearest medical facility for respiratory support measures and symptomatic treatment. General treatment is activated charcoal or gastric lavage, followed by symptomatic and supportive treatment. Specific measures that may be prescribed by the physician, such as diuretics, dialysis or blood transfusion, are unlikely to be effective in eliminating non-steroidal anti-inflammatory drugs, due to the high degree of protein binding and because of the extensive metabolism of the drug Neo nidal.
5. Undesirable effects of the drug Neo-nidal
When using Neo nidal, you may experience the following common side effects:
Digestive disorders: with signs including indigestion, nausea, vomiting, diarrhea; Increase liver enzymes. Less common side effects such as:
Abdominal bloating, indigestion, gastritis, constipation, mouth ulcers, itching, rash; Urticaria on the skin, increased blood urea, increased blood creatinine. Rare adverse effects:
Anemia, anaphylactic reactions, visual disturbances; Heart failure, shortness of breath, increased blood pressure, bone marrow failure, decreased white blood cell count, platelet count; Insomnia, mental confusion, depression, tremor, dreaminess, headache, taste disturbance; Dizziness, ringing in the ears, fast heartbeat; Vasculitis, stridor, bronchospasm; Enteritis, intestinal perforation, skin rash, Stevens-John syndrome, leg cramps; Impaired kidney function, hepatitis, jaundice, liver damage, edema, weight gain; You need to immediately notify the treating doctor if you experience any adverse side effects for timely treatment instructions.
Người bệnh nên hỏi ý kiến bác sĩ trước khi sử dụng giúp tránh các tác dụng phụ của Neo nidal
6. Neo-nidal drug interactions
Neo nidal should not be used in combination with:
Lithium, Digoxin: Aceclofenac active ingredient can increase plasma concentration of active ingredient Lithium or Digoxin. Quinolone antibiotics: Aceclofenac and other non-steroidal anti-inflammatory drugs may potentiate the undesirable effects on the central nervous system of quinolones, leading to an increased risk of convulsions. Oral Anticoagulants and Heparin: Combined with the use of Aceclofenac increases the risk of major bleeding. Methotrexate: Aceclofenac has the potential to increase toxicity to Methotrexate. Neo nidal can inhibit the diuretic activity, increase the nephrotoxicity of cyclosporin. When taking Neo nidal and diabetes medicine at the same time, it can cause blood glucose to rise or fall, but this side effect is quite rare. If Neo nidal is taken at the same time as NSAIDs or corticosteroids, there may be an increased risk of adverse events. To minimize adverse interactions affecting treatment effectiveness and ensure safety, inform your doctor about all medicines including prescription drugs, over-the-counter drugs and foods. function in use.
7. Notes when using Neo-nidal
Gastrointestinal bleeding, ulceration or perforation may occur at any time during treatment with or without pre-existing clinical signs or with or without prior history. As with other NSAIDs, allergic reactions including anaphylactic or anaphylactoid reactions may occur, although rarely. As with other NSAIDs, Neo nidal may lose signs of infection due to its pharmacological action. Ability to drive and use machines: To date, there are no specific reports on the effect of Neo nidal on the ability to drive or use machines. During pregnancy: Neo nidal should be used only when absolutely necessary. The drug should not be used during the third trimester of pregnancy, as it may increase the risk of inhibiting uterine contractions and premature closure of the ductus arteriosus. Lactation: There is no information on the excretion of Aceclofenac into breast milk. However, women who are breastfeeding should avoid use. Neo nidal drug belongs to the group of antipyretic, analgesic and anti-inflammatory drugs that have the effect of treating acute, chronic and anti-inflammatory pain. To ensure the effectiveness of use and avoid unwanted side effects, you should carefully read the instructions or strictly follow the instructions of the treating doctor.
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