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Azasan contains the active ingredient Azathioprine, which has immunosuppressive effects. The drug is indicated in the prevention of rejection in patients undergoing kidney transplant surgery. Let's learn about the uses, dosage and notes when using Azasan through the article below.1. Uses of the drug Azasan
Azasan brand-name drug contains the active ingredient Azathioprine - belongs to the group of immunosuppressive drugs. Azathiprine works by weakening the body's immune system, causing the body to accept the transplanted organ as part of the body (in the case of organ transplant surgery) or prevent joint damage in rheumatoid arthritis.
Clinically, Azasan is indicated in the prevention of organ rejection in kidney transplant patients. Azasan is often used in combination with other drugs to help the patient's kidney transplant surgery go smoothly. For patients with rheumatoid arthritis, Azasan is used to prevent joint damage caused by the body's immune system attack.
2. Dosage of Azasan
Azasan belongs to the group of prescription drugs, so the dose of Azasan is prescribed by the treating doctor. The drug is taken orally, the recommended dose is 1-2 times a day.
Patients should take Azasan after meals to limit side effects on the gastrointestinal tract. The dose of the drug used depends on the patient's medical condition, age, and response. Patients absolutely should not increase the dose of the drug or use it for a longer time than prescribed by the doctor because the risk of side effects can increase significantly.
Azasan used in the treatment of rheumatoid arthritis can last 1-2 months to achieve a therapeutic effect. Patients should notify their doctor in case their condition does not improve after 3 months of taking the drug.
3. Side effects of the drug Azasan
Azasan anti-rejection drug can cause some side effects as follows:
Common: Vomiting, nausea (limit this side effect by taking the drug after meals), hair loss; Uncommon: Joint pain, diarrhea, muscle pain, stomach pain, abdominal pain, jaundice, yellow eyes, dark urine; The drug increases the risk of brain infections (progressive multifocal encephalopathy), which, although rare, are very dangerous. Patients may experience the following symptoms: Loss of balance, weakness, difficulty concentrating, sudden changes in thinking, seizures, changes in vision.
4. Notes when using Azasan
Before treatment with Azasan, the patient should inform the treating doctor if there is a history of liver disease, kidney disease, enzyme disorder (NUDT15 deficiency, TPMT deficiency), cancer, history of drug allergy. Azathioprine, mercaptopurine, or allergies to any other medications or foods.
Azasan can increase the risk of stomach cancer, so during treatment with Azasan patients should limit sun exposure, wear protective clothing and use sunscreen when leaving the house. . In addition, the risk of infection is also increased when patients are treated with Azasan. Patients should limit themselves with infectious agents, especially those who are suffering from infectious diseases such as measles, chickenpox, influenza... Do not vaccinate unless prescribed by a doctor.
Azasan has the ability to be absorbed through the lungs, through the skin into the fetus and cause harm to the fetus. Therefore, women who are pregnant or planning to become pregnant should not be treated with Azasan.
Lactating women: Azathioprine has the potential to be excreted in breast milk and cause harm to a nursing infant. The use of Azasan is contraindicated in lactating women.
In the case of Azasan treatment in organ transplant patients, the patient should be able to attend educational training classes on the topic of transplantation. Learn about signs of organ rejection such as high fever, pain in the transplant area, and signs of organ failure.
5. Azasan drug interactions
Azasan can cause some interactions as follows:
Azasan may interact with some of the following drugs: Febuxostat, cancer drugs (Melphalan, Cyclophosphomid), drugs that weaken the immune system ( Tofacitinib, Rituximab); Azathioprine is similar to mercaptopurinen, so patients should not use the two drugs at the same time because of interactions and increased risk of side effects. Above is important information about the drug Azasan. Using the right medicine in the right amount and in the right amount not only helps the treatment process to be highly effective but also safe for the patient's health.
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