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Pimatussin is a drug used to relieve symptoms of respiratory infections such as colds, allergic rhinitis, flu... So what is Pimatussin and how does it work? Find out through the article below.
1. What is Pimatussin?
Pimatussin medicine has main ingredients including Guaifenesin, Codeine phosphate and Loratadin to help relieve symptoms of colds, coughs due to allergies, expectorant expectorant, relieve symptoms of flu such as sneezing, runny nose, rhinitis . Prepared in capsule form. Guaifenesin has an expectorant effect by irritating the mucous membranes and stimulating the secretion of secretions in the respiratory tract, increasing the volume and reducing the viscosity of secretions in the trachea and bronchi. As a result, the drug increases the effectiveness of the cough reflex, making it easier for the body to expel sputum. This mechanism is different from that of antitussive drugs because it has no effect on relieving cough. The drug is indicated for the symptomatic treatment of cough with thick sputum that is difficult to expectorate and is often combined with bronchodilators, decongestants, antihistamines or opiate antitussives. Codeine: A pain reliever and cough suppressant. Codeine is a methylmorphine that replaces the position of hydrogen in the hydroxyl group associated with the aromatic nucleus in the morphine molecule, so codeine has the effect of helping to relieve pain and relieve cough. Codeine has a cough suppressant effect because it acts directly on the cough center in the medulla oblongata, codeine dries up respiratory secretions and increases the consistency of bronchial secretions. Codeine is a cough suppressant in cases of dry cough that disrupts sleep. Loratadine: Loratadin is an H1-antihistamine, which relieves cough, reduces secretions, and reduces the inflammatory response caused by allergies.2. Uses of Pimatussin
The drug is often indicated to relieve symptoms in the following pathologies:
Relieves symptoms of cough, sneezing, runny nose caused by colds, allergies. Cough with phlegm due to respiratory infections because it has an expectorant effect. Relieves symptoms of seasonal flu such as sneezing, runny nose, rhinitis.
3.How to use and dose Pimatussin
How to use: Pimatussin is prepared in the form of soft capsules for oral use.
Dosage:
Usual dose for adults: Take 1 tablet / day and 2 times a day. Do not use more than 7 days.
Note on Overdosage:
Codeine Overdose: Symptoms of Codeine overdose include respiratory depression, lethargy, lethargy or coma, muscle tenderness, cold and moist skin, sometimes slow and low pulse blood pressure. In severe cases: May cause respiratory arrest, collapse. Management requires respiratory rehabilitation by providing oxygen and controlled respiratory support. Administer naloxone intravenously immediately in severe cases.
Loratadine overdose: Loratadine overdose symptoms include drowsiness, tachycardia, headache. Management requires symptomatic and supportive treatment. In case of acute poisoning can cause vomiting, gastric lavage...
4. Possible side effects when taking Pimatussin
When taking the drug you may experience some side effects including:
Common: Headache, dizziness, thirst and unusual feeling; Nausea, vomiting, constipation; Urinary retention, little urine; Tachycardia, slow pulse, palpitations, weakness, orthostatic hypotension. Uncommon: Allergic reactions such as pruritus, urticaria, respiratory depression, sedation, euphoria, restlessness; Stomach pain, bile duct spasm causing bile obstruction. Rare: Anaphylactic reactions; hallucinations, disorientation, visual disturbances, seizures; circulatory dysfunction; Dry mouth; Red face, sweating, fatigue. Addiction is also a rare reaction: Long-term use of codeine at doses ranging from 240 to 540 mg/day can cause addiction. Common symptoms when medication is not provided are restlessness, muscle tremors, muscle twitching, sweating, and runny nose. Inform your doctor about any unwanted effects you experience while using the drug.
5. Contraindications to taking Pimatussin
Do not use the drug in case:
Patients are sensitive to codeine, Guaifenesin, loratadin or hypersensitivity to any ingredient of the drug. Children under 18 years of age who have just had tonsillectomy or curettage V.A. Patients with liver disease, respiratory failure. It is contraindicated in children under 12 years of age for the treatment of cough due to the high risk of serious and life-threatening adverse reactions. Pregnant women, lactating women. Patients carrying genes that metabolise drugs via CYP2D6 superfast.
6. Notes when using Pimatussin
A few things to keep in mind when taking the drug include:
Before taking the drug, it is necessary to inform the doctor about the history of drug allergy, medical history such as liver and kidney disease, respiratory failure, asthma, emphysema, addiction. drugs and medications being used. Codeine in the drug has a risk of causing respiratory depression, so it should only be used for a short time and should be aware of this side effect. Using loratadine has a risk of causing dry mouth, so it is important to take care of your teeth to avoid tooth decay. This is a symptomatic treatment, so it is necessary to combine drugs to treat the cause, if any. Do not use it for a long time and if symptoms do not reduce, re-examination should be done soon. Do not use the drug in case of coughing up purulent sputum, burning pus in the lungs. Pregnant and lactating women: Because of the risk of effects of ingredients, especially codeine, in the drug, it should not be used. Possible drug interactions when taking concomitant drugs: When used together, this drug may increase the effectiveness of opiate agonists, anesthetics; analgesics, sedatives, tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs), alcohol and other CNS depressants; The analgesic effect of codeine is increased when combined with aspirin and paracetamol, but is reduced or lost by quinidine; Codeine reduces the metabolism of cyclosporin by inhibiting cytochrome P450 enzymes. Store the medicine in a cool, dry place and out of the reach of children. Pimatussin is a combination drug, you need to read the instructions carefully before taking the drug. If you have any questions, consult your doctor or pharmacist.
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