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Pidoespa 75mg medicine is prepared in the form of film-coated tablets with the main ingredient of 75mg Clopidogrel in the form of Clopidogrel bisulphate. So what is Pidoespa, what is the use of the drug and how to use it?1. Uses of Pidoespa 75mg
The main ingredient of Pidoespa is clopidogrel, which is a selective inhibitor of the binding of adenosine diphosphate (ADP) to its receptor located on platelets and to the ADP-mediated activation of the glycoprotein complex. GPIIb/IIIa. Therefore, this active ingredient has an inhibitory effect on platelet aggregation.Clopidogrel biometabolism is required for the induction of inhibition of platelet aggregation, however, the active metabolite of Clopidogrel has not been isolated. Clopidogrel's effects on ADP receptors on platelets are irreversible.
Pidoespa 75mg is indicated in the following cases:
Primary prevention of thromboembolic disorders such as myocardial infarction, ischemic stroke and peripheral arterial disease. Control and secondary prevention for atherosclerotic patients with recent myocardial infarction, recent stroke, or established peripheral arterial disease. Pidoespa 75mg is contraindicated in the following cases:
People with hypersensitivity to any ingredient of Pidoespa. Patients with bleeding disorders such as peptic ulcer or intracranial hemorrhage. Severe liver failure Precautions when using Pidoespa 75mg in the following cases:
Patients with bleeding due to trauma, surgery or other diseases. Patients who are about to have surgery should stop taking Pidoespa 5 days before surgery. Pidoespa should be used with caution in patients with hemorrhagic lesions (such as ulcers). Care should be taken when administering drugs that may cause bleeding lesions (such as ulcers) in patients taking Pidoespa. Patients with liver failure. Persons with changes in metabolism such as poor metabolisers due to CYP2C19. There are no adequate studies on the use of Pidoespa in pregnant women. Pregnant women should only use Pidoespa when clearly needed. There have been no studies on the excretion of clopidogrel into breast milk. Pidoespa should be used with caution in nursing women. Pidoespa does not affect the ability to drive and use machines.
2. Dosage and how to use Pidoespa 75mg
Pidoespa 75mg is used by mouth, can be taken with or without food. The dosage of Pidoespa should be according to the doctor's prescription, the reference dose in specific cases is as follows:Patients with a history of atherosclerosis: Use a dose of 1 tablet (75mg) per day. Prophylactic dose of Pidoespa to prevent thromboembolic disorders such as myocardial infarction, stroke, peripheral artery disease: Use a dose of 1 tablet (75mg)/day. Acute coronary syndromes (e.g. unstable angina, non-Q-wave myocardial infarction): Initial dose of 300 mg as a single dose, followed by a maintenance dose of 75 mg daily . No dose adjustment of Pidoespa is required in the elderly or in patients with renal impairment. An overdose of Pidoespa will lead to prolonged bleeding time and then complications of bleeding. Symptoms of acute toxicity of Pidoespa are vomiting, fatigue, dyspnea and gastrointestinal bleeding.
3. Pidoespa side effects
Pidoespa is generally easy to tolerate, but there are still some side effects when using the drug.Common side effects of Pidoespa 75mg include:
Gastrointestinal disturbances such as diarrhea, abdominal pain, indigestion and nausea. Skin allergies such as erythema, itching. Less common side effects of Pidoespa 75mg include:
Chest tightness. Epistaxis. Rare side effects of Pidoespa 75mg include:
Gastrointestinal bleeding. Stomach ulcers. Neutropenia. Severe agranulocytosis. Thrombocytopenia. Purpura due to thrombocytopenia. Aplastic anemia. Nephritis syndrome. Loss of taste. Acute arthritis. Other side effects of Pidoespa 75mg include:
Intracerebral hemorrhage. Bleeding in the eye.
4. Interaction of Pidoespa 75mg with other drugs
Use of Pidoespa with Aspirin may occur pharmacodynamic interactions leading to an increased risk of bleeding. Therefore, caution should be exercised when combining these two drugs. However, Pidoespa and Aspirin can be used in combination for up to 1 year. Concomitant use of Pidoespa with Heparin may result in a pharmacodynamic interaction leading to an increased risk of bleeding. Therefore, the simultaneous use of these two drugs should be noted. Using Pidoespa with Warfarin may increase the risk of bleeding. Concomitant use of Pidoespa with non-steroidal anti-inflammatory drugs (NSAIDs) may increase the potential for gastrointestinal bleeding. Therefore, caution should be exercised when using Pidoespa concomitantly with non-steroidal anti-inflammatory drugs. Clopidogrel in Pidoespa may cause Cytochrome P450 (2C9) inhibition affecting drugs metabolized by the cytochrome P450 system such as phenytoin, tolbutamide, warfarin, furosemide, tamoxifen, fluvastatin and many other non-steroidal anti-inflammatory agents. Concomitant administration of Pidoespa with inhibitors of CYP2C19 enzyme activity may result in decreased concentrations of the active metabolite of Clopidogrel. Therefore, caution should be exercised when Pidoespa 75 mg is co-administered with CYP2C19 inhibitors including omeprazole, esomeprazole, fluoxetine, fluvoxamine, fluconazole, moclobemide, voriconazole, ticlopidine, ciprofloxacin, carbamazepine, cimetidine, oxcarbazepine and chloramphenicol. Above is information about Pidoespa 75mg medicine. If you have any further questions about your medication, contact your doctor or pharmacist immediately.
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