Uses of Intagril 75

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1. What is Intagril 75?

What is Intagril 75? 1 Intagril 75 tablet contains Clopidogrel Bisulfate USP equivalent to 75mg Clopidogrel and other excipients. Clopidogrel is a platelet adhesion inhibitor. The drug inhibits the binding of adenosine diphosphate (ADP) to the platelet receptor, which then inhibits the activation of the glycoprotein compound GPIIb/IIIa mediated by ADP, inhibiting platelet adhesion. Clopidogrel's biological metabolite inhibits platelet adhesion (but so far has not been isolated). Clopidogrel does not inhibit the activity of the enzyme phosphodiesterase.
Indications for use of Intagril 75:
To reduce the consequences of atherosclerosis (myocardial infarction, stroke and vascular death) in patients with atherosclerosis who have an existing stroke, myocardial infarction, peripheral artery disease. Contraindications to the use of Intagril 75:
Patients are sensitive to the ingredients and active ingredients of the drug; Patients with severe liver failure; The patient is suffering from pathological bleeding such as peptic ulcer or intracranial hemorrhage.

2. Usage and dosage of Intagril 75

How to use: Orally, Intagril 75 can be taken with or without food.
Dosage:
Patients with a history of atherosclerosis: Use a dose of 75mg/time/day; Prophylaxis and prevention of thromboembolic disorders (myocardial infarction, stroke, peripheral artery disease): Use dose 75mg/time/day; Acute coronary syndromes (unstable angina, non-Q-wave myocardial infarction): Start with 300 mg as a single dose. Then maintain at a dose of 75mg/time/day; Patients with renal impairment : It is not necessary to change the dose of the drug; Elderly: It is not necessary to change the dose of the drug. Overdose: When using an overdose of Clopidogrel, patients may experience symptoms of acute poisoning such as vomiting, exhaustion, gastrointestinal bleeding, difficulty breathing. Treatment is based on the biological principle of platelet transfusion to rapidly reverse the pharmacological effects of clopidogrel.
Missed dose: When forgetting a dose of Intagril 75, the patient should not arbitrarily make up for it, but should consult a doctor to receive the most appropriate advice.

3. Side effects of Intagril 75

Clopidogrel is considered to be well tolerated and quite safe for patients. Tolerability was generally comparable to aspirin regardless of age, race, and sex. Approximately 13% of patients abandon treatment because of side effects. Some clinical side effects recorded when using Clopidogrel are:
Gastrointestinal tract: Abdominal pain, indigestion, constipation, nausea, vomiting, gastritis, diarrhea, intestinal prolapse; Skin: Skin rash, itchy skin, eczema, skin ulcers; Body as a whole: Pain, fatigue, weakness; Cardiovascular: Edema, hypertension, atrial fibrillation, heart failure; Peripheral and central nervous system: Headache, dizziness, vertigo, cramps, decreased touch, paresthesia, neuralgia; Blood: Gastrointestinal bleeding, cerebral hemorrhage, neutropenia, agranulocytosis, thrombocytopenia and coagulopathy, hematoma, thrombocytopenia, purpura, epistaxis, anemia ; Hepatobiliary: Increased liver enzymes; Nutrition and metabolism: Uremia, gout, hypercholesterolemia, non-protein nitrogen (NPN) elevation; Musculoskeletal: Back pain, joint pain, joint disease, arthritis; Respiratory: Upper respiratory tract infection, rhinitis, bronchitis, shortness of breath, cough, pneumonia, sinusitis; Urinary: Cystitis, urinary tract infection; Vision: Conjunctivitis, cataracts. Patients should inform their doctor about adverse reactions when using Intagril 75 to know the most appropriate response and management.

4. Be careful when using Intagril 75

Before and during the use of Intagril 75, patients should:
Use caution when using Clopidogrel in patients at high risk of bleeding from trauma, surgery or other medical conditions. If the patient is about to undergo an elective surgery and does not require antiplatelet therapy, clopidogrel should be discontinued 7 days prior to surgery; Clopidogrel can prolong bleeding time, easily cause gastrointestinal bleeding. Clopidogrel should be used with caution in patients with bleeding lesions (such as ulcers). These drugs (aspirin and non-steroidal anti-inflammatory drugs) should be used with caution in patients receiving clopidogrel; There is little experience with the use of Intagril 75 in patients with severe hepatic impairment who may have bleeding organs. Therefore, caution should be exercised when clopidogrel is used in this group of patients; Animal studies have shown no evidence that clopidogrel reduces fertility or causes fetal toxicity. However, there are currently no well-controlled studies in pregnant women. Therefore, only use Clopidogrel in pregnant women when it is absolutely necessary and has been approved by the doctor; Studies in rats have shown that Clopidogrel and its metabolites are excreted in milk. It is not known whether clopidogrel is excreted in human milk. Therefore, the importance of the drug to the mother should be taken into account when deciding whether to discontinue the drug or to discontinue breastfeeding on a case-by-case basis; The safety and effectiveness of clopidogrel in children have not been established. Intagril 75 can cause dizziness, lightheadedness and somnolence, so caution should be exercised when using it in people who drive, operate machinery or perform tasks requiring alertness.

5. Intagril drug interactions 75

Some drug interactions of Intagril 75 that patients need to be aware of include:
Aspirin does not change Clopidogrel's ability to inhibit AP-induced platelet aggregation. Concomitant administration of 500 mg aspirin twice daily did not significantly increase the bleeding time associated with clopidogrel. However, clopidogrel potentiates the anti-collagen-induced antiplatelet effect of aspirin; Co-administration of Heparin with Clopidogrel did not affect the platelet aggregation of Clopidogrel. However, the safety of the combination of these two drugs has not been proven, so caution should be exercised when used at the same time; In healthy subjects being treated with naproxen at the same time as clopidogrel there is an increased risk of potential gastrointestinal blood loss. Therefore, caution should be exercised when clopidogrel is used in combination with non-steroidal anti-inflammatory drugs; The safety of clopidogrel with warfarin has not yet been established. Therefore, caution should be exercised when taking these two drugs at the same time; No significant pharmacodynamic interactions have been observed when clopidogrel is co-administered with nifedipine, atenolol or both nifedipine and atenolol. The pharmacokinetics of Clopidogrel were also not significantly affected when co-administered with estrogen, cimetidine or phenobarbital; Clopidogrel is partially metabolised by the enzyme CYP2C19 to the active metabolite. The combined use of these drugs inhibits the enzyme CYP2C19, reduces plasma concentrations and reduces platelet inhibition. Therefore, the concomitant use of Clopidogrel with CYP2C19 inhibitors such as omeprazole should be avoided; Clopidogrel may interfere with the metabolism of phenytoin, tolbutamide, tamoxifen, warfarin, fluvastatin, torsemide and many other nonsteroidal anti-inflammatory drugs. However, there are no data on the importance of these drugs. Caution should be exercised when any one of these drugs is administered concurrently with clopidogrel. During the use of Intagril 75, the patient must strictly follow all the instructions of the doctor. Patients must not arbitrarily change the dose, time of taking the drug or stop using the drug without the permission of the doctor to avoid many unpredictable consequences.
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