This is an automatically translated article.
Pancrezym belongs to the group of gastrointestinal drugs in the form of tablets. The main ingredient of Pancrezym is ursodeoxycholic acid, which is indicated in the improvement of chronic hepatitis function.
1. Mechanism of action of the drug Pancrezym
The main ingredient of Pancrezym is Ursodeoxycholic, a natural bile salt with low content in the body (it is different from other endogenous bile acids). Ursodeoxycholic is very hydrophilic and has no detergent effect. It has an effect on the enterohepatic cycle of endogenous bile acids, helps to increase bile secretion, and reduces the absorption of bile by inhibiting active intestinal reabsorption. Thereby reducing the concentration of endogenous bile acids in the blood.
Using the drug Pancrezym is one of the measures to treat gallstones of cholesterol nature by helping to reduce the concentration of this substance in bile with a combination of many different mechanisms such as: Reducing cholesterol reabsorption, increasing cholesterol. cholesterol metabolism in the liver...
2. Indications and contraindications to the use of Pancrezym
Pancrezym brand name drug is indicated in the treatment of improving liver function in people with chronic hepatitis . Pancrezym drug also helps protect and restore liver cells before and after drinking alcohol. In addition, Pancrezym drug also supports the treatment of indigestion, anorexia in case of intestinal disorders or supports the treatment of cholesterol gallstones, cholecystitis, inflammation of the biliary tract.
However, Pancrezym is contraindicated in cases of hypersensitivity to the drug's ingredients, people with bile duct obstruction, pregnant women
3. Dosage and how to use Pancrezym
Pancrezym is used after meals. The drug should be used in the evening or divided into 2 times morning and evening.
For the treatment of cholesterol gallstones: Use Pancrezym at a dose of 5 to 10mg/kg/day. The average recommended dose for this subject is about 7.5mg/kg/day for normal people. But for people with obesity, the recommended dose of Pancrezym is 10mg/kg/day.
The usual duration of treatment with Pancrezym is 6 months. But if the stone is larger than 1cm, it needs to be treated for up to 1 year. For the treatment of acute hepatobiliary disease, the dose is from 13 to 15mg/kg/day. Start with Pancrezym 200mg/day and then gradually increase to the maximum therapeutic dose. Treatment duration is about 4 to 8 weeks
For the treatment of acquired hepatobiliary diseases due to viscous mucus disease, the maximum therapeutic dose of Pancrezym is 20mg/kg/day.
Note: The recommended dosage of Pancrezym above is for reference only. Therefore, before using Pancrezym, patients need to follow the doctor's instructions.
4. Management of missed dose and overdose Pancrezym
If you miss a dose of Pancrezym, use it as soon as you remember. However, if the interval between the missed dose of Pancrezym and the next dose is too close, skip the missed dose. Patients should not double the dose of Pancrezym, because it can cause drug overdose. To overcome the situation of missing doses of Pancrezym, patients can set alarms or ask relatives to remind them.
In case of accidentally using Pancrezym drug overdose than prescribed and showing some unwanted signs, relatives need to take the patient to the emergency hospital immediately.
5. Side effects when using Pancrezym
Pancrezym medicine can cause some unwanted side effects during treatment. However, with each case, side effects of Pancrezym drug can occur in varying degrees from mild to severe.
Some common side effects caused by Pancrezym include: Nausea and vomiting, headache, diarrhea, itching... These side effects may occur at the beginning of treatment or after increasing the dose. amount of Pancrezyme. Usually, side effects from Pancrezym can be transient or subside over time.
However, in some cases Pancrezym can cause serious unwanted side effects with rare reactions. These reactions may appear after just a few minutes of using Pancrezym or longer within a few days. When serious side effects appear such as: intestinal mucosal irritation, urticaria, cholestasis, ... the patient should stop using Pancrezym and go to a medical facility for immediate medical assistance.
Some notes during the use of Pancrezym:
For pregnant and lactating women, caution should be exercised when using Pancrezym. Patients should be advised to use Pancrezym from their doctor, and carefully analyze the benefits and risks before using the drug. Pancrezym may change how it works and increase its side effects. Therefore, to avoid drug interactions with Pancrezym, the patient should provide the doctor with a list of previously used drugs, including prescription and non-prescription drugs, dietary supplements or herbs,... Caution when using Pancrezym for subjects with liver dysfunction. Above is the important information about Pancrezym drug, patients should carefully read the instructions for use and use according to the dose prescribed by the doctor to achieve the best effect.
