Uses of Ospex

This is an automatically translated article.

1. What is Ospex?

Ospex drug is a product of Synmedic Laboratories Company (India), with the main ingredient being Microcrystalline Hydroxyapatitec 600mg (compound ossein - hydroxyapatite anhydrous) = 321mg Hydroxyapatite equivalent to: Calcium 129mg and Phosphorus 58mg. In addition, the drug also includes many other excipients such as: Microcrystalline Cellulose, Sodium Croscarmellose, Sodium Starch Glycolat, Colloidal Anhydrous Silica, Magnesium Stearate, Purified Talc, Hydromellose, Titanium Dioxide, Ethylcellulose, Yellow Iron Oxide.
The drug is used in the case of both calcium and phosphorus supplementation in pregnant and lactating women, in the period of body development (children, boys, girls and adolescents), taking supplements to avoid osteoporosis in elderly, menopausal and post-menopausal women.
Ospex is available in the form of film-coated tablets. The drug is packed in 10 blisters in 1 box, 6 tablets/blister.

2. Uses of Ospex

Ospex 600 is applied effectively in the following cases:
Provide calcium for children and the elderly to develop healthy bones and tissues The drug is prescribed to treat and prevent osteoporosis. Increases bone density Helps maintain bone and teeth health. Calcium supplements for postmenopausal women. Pregnant and lactating women need calcium supplements. On the other hand, Ospex is not indicated in the following cases:
People who are sensitive to calcium or any of its ingredients. Patients with hypercalcemia, severe hypercalcemia Patients with liver and kidney failure Pharmacodynamics
Microcrystalline hydroxyapatite is a microcrystalline form of calcium and phosphorus in the exact proportions that are formed in the body.
Calcium is the most important mineral component of bones, necessary for many functions in the body. Bones contain 99% of the total calcium in the body in a crystalline form similar to the mineral hydroxyapatite.
Phosphorus is an essential component in all tissues of the body. More than 80% of the body's total phosphorus is found in bones, and about 15% in soft tissues. Phosphorus is a component of phospholipid membranes. In the body calcium and phosphorus together play a role in maintaining the development and structure of the skeleton.
On pharmacokinetics
Calcium is transported across the intestinal mucosa by a protein-specific transporter. Absorption of calcium from the intestine to the villi border is accelerated in the presence of vitamin D. Most of the calcium is found in the feces, this is probably due to the unabsorbed amount of calcium in the food and partly to the calcium from the cells. epithelial cells and digestive juices. Calcium reabsorption depends on many factors. Normal urine contains between 100 - 350mg of calcium per day, this amount varies from person to person and is often high in the summer.
Phosphate is absorbed from the intestine. In adults, about two-thirds of the oral phosphate intake is absorbed and excreted almost entirely in the urine. The plasma phosphate concentration of children is higher than that of adults.
Phosphate is present in plasma and extracellular fluid, in cell membranes and in intracellular fluid, in collagen and bone. In the extracellular fluid, phosphate exists as inorganic, the concentration of inorganic substances in plasma varies with age. Renal excretion of phosphate, more than 90% of the plasma phosphate concentration is filtered by the kidneys, of which 80% is reabsorbed.

3. Usage and dosage

Ospex 600 is to be taken orally. When taking, you should swallow the tablet whole with water, do not crush or chew the tablet. The drug is intended for use in adults and children over 15 years of age.
The dose of medicine prescribed depends on the age and purpose of the patient. Specifically:
Adults and children over 15 years old: 6 - 12 tablets/day, divided into 3 times. Children 6-14 years old: 3-9 tablets/day, divided into 3 times. Children under 6 years: Use other dosage forms as appropriate (eg Oral solution). Note: Each person will be prescribed a different medicine, so you should not share a prescription with others. The above dosage is for reference only. To get the right dosage you need to consult and consult your doctor.
Currently, there have been no cases of overdose Ospex 600. However, in case of drinking too much, you should notify your doctor for timely treatment.
Conversely, if you miss a dose of Ospex 600, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Never take twice the prescribed dose.

4. Ospex 600 . side effects

Ospex can cause some side effects, affecting the health and quality of life of the patient. Some of the side effects can include:
Digestive disorders: Diarrhea, constipation, flatulence, abdominal pain, nausea Stone formation in the urinary tract Delirium, confusion, coma Above Not all symptoms of side effects from Ospex. If the patient experiences any abnormal signs suspected of taking the drug, please notify the doctor for timely handling measures.

5. Drug interactions

Drug interactions occur that may reduce the effectiveness of the drug or increase the unwanted side effects of Ospex. Here are some drugs when used concurrently with Ospex may cause interactions:
Co-administration of Ospex 600 with Fluoroquinolone antibiotics may reduce drug absorption due to calcium content. Therefore, calcium supplements and dairy products should not be taken within 2 hours before or after taking antibiotics. Combination with Levothyroxine also reduces the absorption of Ospex Iron: High doses with calcium may decrease the absorption of iron. Zinc: High doses with calcium may decrease the absorption of zinc. Thiazide diuretics combined with Ospex will increase blood calcium. Co-administration with Atenolol reduces the maximum plasma concentration of atenolol. Iron salts: The absorption of iron in the gastrointestinal tract is reduced. Tetracycline antibiotics: Decreased absorption and serum concentrations of tetracyclines. Verapamil: Clinical efficacy and toxicity of verapamil are altered.

6. Notes when using Ospex

In order to use the drug safely, patients need to "take to heart" the following notes:
Patients with liver and/or kidney failure need to carefully consider and discuss with their doctor before prescribing Must check Investigation of urinary calcium excretion in patients with mild hypercalciuria (exceeding 300 mg 7.5mol/24 hours) Drink plenty of fluids in patients with possible urinary tract stones. The drug is safe to use for pregnant and lactating women, but consult a doctor about dosage For pediatrics, the drug is safe to be taken at the recommended dose

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