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Rovamycine drug with the main ingredient Spiramycin is made in the form of film-coated tablets. The drug is indicated in the treatment of infections of the upper and lower respiratory tract, ENT, bronchial or in the prevention of relapse of acute rheumatic fever... However, Rovamycine may bring some side effects. unexpected. Therefore, before using Novomycin, patients should carefully study the information and follow the doctor's instructions.
1. Mechanism of action of the drug Novomycin
What is Novomycin? Novomycin contains Spianmyccin belonging to the group of macrolide antibiotics that are active against bacteria that are dividing cells. Mechanism of action of the drug on the 50S subunit of the bacterial ribosome and prevents the bacteria from synthesizing proteins. When the drug Novomycin reaches the average concentration in the serum, it will have the main effect of inhibiting the bacteria, but when reaching the high concentration, the drug Novomycin can kill the bacteria slowly for much sensitive bacteria.
Furthermore, resistance to macrolides is often related to a process that alters the drug's target site. Mechanism of resistance may be chromosomal or plasmid mediated. Then resistant bacteria can produce adenin methylation enzyme in ribosomal RNA, inhibiting the binding of Novomycin to the ribosome.
The drug has no effect on gram-negative intestinal bacteria, and cross-resistance among compounds spiramycin, erythromycin, oleandomycin.
Novomycin is incompletely absorbed from the gastrointestinal tract and may be reduced when taken with food. Therefore, serum drug concentrations when taken with a meal will be about 2 hours slower than without a meal.
2. Indications for the use of Novomycine
Novomycin is indicated in the treatment of infections or infections of the respiratory tract, skin and genitals with agents caused by bacteria sensitive to spiramycin. Or prevent meningococcal meningitis when rifampicin is contraindicated. However, the drug Novomycin is also contraindicated in cases of hypersensitivity to the components of the drug or to the group of macrolide antibiotics.
3. Dosage and usage of Novomycin
Novomycin is used at least two hours before meals or at least 3 hours after meals. The patient should swallow the tablet whole with a full glass of water. The recommended adult dose of 6 million to 9 million IU/day is equivalent to 2 to 3 Novomycin tablets and is divided into 2 to 3 doses per day. Duration of treatment can be 10 days
Novomycin is used to prevent meningococcal meningitis with a recommended dose of 3 million IU/12 hours and used for 5 days
Note: The recommended therapeutic dose above for the drug Novomycin is for reference only. Therefore, before using Novomycin, patients need to be prescribed by a doctor.
If you have missed a dose of Novomycin, take the missed dose as soon as you remember. However, if the interval between the missed dose of Novomycin and the next dose is too close, skip the missed dose. Patients should not double the dose of Novomycin, because it can cause an overdose. To overcome the situation of missing doses of Novomycin, patients can set an alarm or ask family members to remind them.
In case of accidentally using Novomycin drug in excess of the prescribed dose and showing some unwanted signs such as abdominal pain, nausea and vomiting, diarrhea, fatigue, dizziness, low blood pressure , shortness of breath, drowsiness, itching... need to take the patient to see a doctor right away
4. Unwanted side effects when using Novomycin
Rovamycine medicine may cause some unwanted side effects during treatment. However, with each case, Novomycin can occur in varying degrees from mild to severe.
Some common side effects caused by Vancomycin include: nausea and vomiting, diarrhea, indigestion, dizziness, headache, fatigue, nosebleeds, sweating, acute colitis... These side effects may occur at the beginning of treatment or after increasing the dose of the drug used. And often these reactions can be transient or subside over time.
However, in some cases Novomycin can cause serious unwanted side effects with rare reactions. These reactions may appear after just a few minutes of using Novomycin or longer within a few days. When serious side effects appear such as: superinfection due to long-term drug use, skin rash, urticaria... the patient should stop using Novomycin and need immediate medical assistance.
Although this is not a complete list of unwanted side effects of Novomycin, if the patient feels unusual signs during treatment, they should immediately notify the doctor or medical staff.
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