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Amohexine is commonly used in the treatment of diseases related to the upper and lower respiratory tract. When taking Amohexine, the effects and risks go hand in hand. To achieve the most optimal treatment effect, patients should carefully consult the recommendations of the specialist before taking Amohexine.
1. What is Amohexine?
Amohexine belongs to the group of drugs that act on the respiratory tract, is a pharmaceutical that helps bring effective treatment to diseases related to the respiratory tract caused by bacteria.
Amohexine is a hard capsule, packed in a box of 10 blisters x 10 tablets. In each Amohexine capsule contains the following main ingredients:
Active ingredient Amoxicillin (exist in the form of Trihydrate) with a content of 500mg. Bromhexine HCl is 8mg. Other excipients are sufficient. Amohexine is stored at room temperature (< 30 degrees Celsius), avoiding exposure to direct sunlight to ensure the quality of the drug. In addition, Amohexine should also be stored in a dry place, out of the reach of children.
2. Indications and contraindications for the use of Amohexine
2.1 Indications for the use of Amohexine What disease does Amohexine treat? Currently, Amohexine is often prescribed by doctors for the following cases:
Treatment of infections in the upper respiratory tract such as sinusitis, tonsillitis or otitis media. Treatment of lower respiratory tract infections such as lobar pneumonia, exacerbation of chronic bronchitis, bronchial pneumonia. Treat gastrointestinal infections such as typhoid fever. Treatment of urinary tract infections such as gonorrhea, pyelonephritis. Treatment of obstetric infections or septic abortions. Treatment of other infections such as endocarditis, bacteremia, meningitis caused by susceptible bacteria (can be initiated with high-dose amohexine or in combination with another antibiotic). Prophylaxis of endocarditis, preventing bacteremia from developing endocarditis. Treatment of persistent cough with profuse phlegm. Treatment of chronic cough. Treatment of chronic obstructive pulmonary conditions. Treatment of chronic respiratory infections. Treatment of bronchiectasis or lung dust. 2.2 Contraindications to using Amohexine Do not use Amohexine for the following cases:
People who are allergic or have hypersensitivity reactions to active ingredients such as Amocicillin, Bromhexin HCl or some other excipients contained in the drug. People who are suffering from kidney and liver related diseases, such as impaired liver / kidney function, kidney failure, liver failure,... Relatively contraindicated for pregnant or nursing women by breast milk.
3. Effects of ingredients in the drug Amohexine
Amoxicillin Amoxicillin component in the drug Amohexine is an Aminopenicillin, which is stable in acidic media and offers a broader spectrum of action than Benzylpenicillin. Typical is the ability to fight Gram (-) bacilli. Like other penicillins. Amoxicillin is bactericidal by blocking the biosynthesis of mucopeptides in the bacterial cell wall.
According to research, the Amoxicillin component in Amohexine is active against most Gram-positive and Gram-negative bacteria, including non-penicillinase-producing staphylococcus, streptococcus, Diplococcus pneumoniae, H. influenzaem, N.gonorrhoeae, Proteus mirabilis and E.coli . However, Amoxicillin is not active against penicillinase-producing bacteria, especially Methicillin-resistant staphylococci, Pseudomonas, Enterobacter and Klebsiella strains.
Bromhexin hydrochloride Bromhexin hydrochloride in Amohexine is a substance that helps regulate and clear mucus in the respiratory tract. Thanks to the mechanism of activating the synthesis of sialomucin, and at the same time breaking down the mucopolysaccharid acid fibers, Bromhexin HCL can loosen the sputum in the respiratory tract more easily and with less consistency, thereby helping the sputum from the bronchi to escape. effectively outside.
4. Dosage and usage of Amohexine
4.1 Dosage of Amohexine The dose of Amohexine to be used will be determined based on the patient's age, specifically:
Children from 2 to 6 years old: Take half a tablet / time, 2 times / day. Children from 6 to 12 years old: Take half a tablet / time, 3 times / day. Adults and children 12 years and older: Take 1 tablet 3 times a day. 4.2 How to use Amohexine Because Amohexine is made in the form of hard capsules, it should be taken orally with cooled boiled water. Patients should take the medicine with a full glass of water to make it easier for the medicine to enter the stomach.
4.3 Management of Amohexine Overdose When taking more than the recommended dose of Amohexine, patients may experience symptoms such as nausea, vomiting or persistent diarrhea, even severe convulsions. When any of the above signs appear after taking more than the recommended dose of Amohexine, the patient should be taken to a medical facility for examination and early treatment.
Some methods to help overcome current drug overdose, including gastric lavage, vomiting, activated charcoal,... During the treatment, the doctor will check the blood pressure indicators, breathing rate, ... of the patient. Symptomatic measures of overdose are also used to prevent their progression.
5. Some side effects of the drug Amohexine
Unintended side effects of Amohexine are rare, most of which are mild and temporary, and do not have long-term effects on the patient's health. Some of the side effects that patients may experience during treatment with Amohexine:
Drug hypersensitivity reactions such as itching, skin rash, urticaria, erythema multiforme, skin necrosis toxicosis, Stevens-Johnson syndrome, bullous dermatitis... Gastrointestinal side effects such as nausea, vomiting, intestinal candidiasis, diarrhea, colitis. Hepatic reactions such as cholestatic jaundice, hepatitis. Renal reactions such as crystalluria. Effects on hematology such as transient thrombocytopenia, transient leukopenia, hemolytic anemia, persistent bleeding, prolongation of prothrombin time. CNS effects such as dizziness, hyperactivity or convulsions. Amohexine side effects are not a complete list. During treatment with Amohexine, patients may experience other side effects that have not been studied. If any side effects are noticed after taking Amohexine, the patient should immediately inform the pharmacist/specialist for appropriate remedial measures.
6. Things to note when using Amohexine
6.1 What precautions should be taken during treatment with Amohexine? Before and during the use of Amohexine, patients need to be cautious of the following to avoid adverse reactions, including:
Patients with a history of peptic ulcer disease should consult their doctor. doctor before taking Amohexine. Kidney and liver function should be checked before taking Amohexine. Pregnant women and women who are breastfeeding should consider before being treated with Amohexine to ensure the health of both mother and baby. People who operate machines or vehicles need to be careful because the drug can cause headaches as a side effect. Always closely monitor the body's manifestations during the time you take Amohexine. Use with caution in asthmatics because the Bromhexin component in the drug can cause bronchospasm in susceptible subjects. Patients with debility, weakness and inability to expectorate sputum should be used with caution. Fully inform the doctor about your current health condition, including medical history, allergies,... Elderly people need to be careful when taking drugs, because this object tends to be sensitive. with drugs than in the general population. Read the instructions carefully before using Amohexine to avoid unnecessary harm. 6.2 What other drugs does Amohexine interact with? When 2 or more drugs are used together, the risk of drug interactions may increase, leading to synergism or antagonism. In expert judgment, drug interactions can increase the severity of side effects or alter the ability of medications to work. On the other hand, the use of interacting drugs is considered a factor leading to many different outcomes for the patient's health, which can be bad or good. Therefore, patients need to consult their doctor or pharmacist very carefully before using drugs together.
The following are some drugs that can interact with Amohexine, including:
Co-administration with Probenecid can reduce the excretion of the active substance Amoxycillin in the renal tubules, while increasing and prolonging the concentration of the drug Probenecid. of Amoxycillin in the blood. Food in the stomach does not affect the absorption of Amoxycillin, so patients can take the drug before / after meals. Taking Amohexine with Nifedipine may increase the absorption of Amoxycillin in the body. Taking Amohexine with Allopurinol may increase the risk of Amoxycillin rash. Antagonism occurs between bactericidal Amoxycillin when co-administered with bacteriostatic agents such as Tetracycline and Chloramphenicol. Some other drugs can interact with Amohexine, including Atropin, antibiotics,... In addition, the use of Amohexine with foods, beer, tobacco or alcohol can lead to phenomenon. synergistic or antagonistic, because in those substances and foods contain different active ingredients. Ideally, patients should tell their doctor about all medications they are currently taking, including over-the-counter drugs, minerals, vitamins, or herbal products.
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