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Nikoramyl 5mg is commonly prescribed by doctors for the long-term control of coronary heart disease as well as the effective treatment of stable angina. During the course of using Nikoramyl 5mg, patients need to strictly follow the treatment plan prescribed by the doctor to minimize the risk of experiencing side effects.
1. What is Nikoramyl 5mg?
Nikoramyl 5mg drug belongs to the group of cardiovascular drugs, often prescribed by doctors for people with coronary artery disease. Nikoramyl 5mg is a product of Ha Tay Pharmaceutical Joint Stock Company, made in the form of hard capsules (white - purple) with packaging of 3 blisters x 10 tablets. Each capsule of Nikoramyl 5mg contains the main active ingredient, Nicorandil, with a concentration of 5mg and other excipients just enough. The active ingredient Nicorandil belongs to the Nitrate derivative of Nicotinamide, has a vasodilator effect and acts on the arterioles as well as the large coronary arteries through the mechanism of calcium channel opening. Moreover, Nicorandil also has the ability to stimulate Guanylate cyclase, thereby dilating veins. It is thanks to this use that Nikoramyl 5mg can reduce both pre and afterload, support increased blood flow to the coronary arteries and effectively relieve angina.
2. Indications and contraindications for the use of Nikoramyl 5mg
2.1 Indications to use Nikoramyl 5mg drug Nikoramyl 5mg is usually prescribed by doctors for the following cases:
Helps prevent and effectively treat stable angina. Used to reduce acute coronary syndromes in high-risk subjects. Indicated for the long-term control of patients with coronary artery disease. 2.2 Contraindications to the use of Nikoramyl 5mg Do not use Nikoramyl 5mg in the following cases:
Patients with allergies or hypersensitivity to Nicorandil ingredients or any other active ingredients in the drug. Nicorandil is contraindicated in patients with cardiogenic shock, left heart failure or severe hypotension. Do not use Nikoramyl 5mg for people with hypovolemia, hyperkalemia or acute pulmonary edema. Contraindicated in patients with ocular mucosal ulceration, G6PD reduction, or gastrointestinal ulceration.
3. Dosage and how to use Nikoramyl 5mg
3.1 Dosage of the drug Nikoramyl 5mg Dosage of the drug Nikoramyl 5mg as recommended by the doctor that the patient can refer to apply, including:
Starting dose: Take 2 tablets / time, 2 times / day or 1 tablets twice a day for patients prone to headaches. In case of necessity, the dose can be increased up to 30mg / time, taken 2 times / day. Maintenance dose: Take 10-20mg / time, use 2 times / day. 3.2 Instructions for proper use of Nikoramyl 5mg drug Nikoramyl is used orally due to its preparation in the form of hard capsules. Patients should take the drug with a glass of water about 200-250ml.
Before taking Nikoramyl, you should read the instructions for use carefully and make sure to follow the medication plan recommended by your doctor. Absolutely do not arbitrarily use drugs, increase / decrease the dose without the approval of the doctor.
3.3 How to deal with Nikoramyl 5mg overdose An overdose of Nikoramyl 5mg can cause noticeable symptoms in the patient such as peripheral vasodilation, decreased blood pressure and reflex increase in heart rate. In this situation, the best thing that the patient needs to do is to stop taking the drug and go to the medical facility for early treatment. The treatment of drug overdose Nikoramyl 5mg usually includes measures such as gastric lavage, prompting vomiting, using activated charcoal, ...
4. Possible side effects when taking Nikoramyl 5mg
Nikoramyl 5mg drug can cause the following side effects during use, including:
Transient headache in the early stages of treatment, nausea, vomiting, blushing, lower vasodilation skin, dizziness or fatigue. Rarely, side effects such as muscle pain, mouth ulcers, and red skin rashes have been reported. For symptoms of mouth ulcers, aphthous symptoms often appear late and are often encountered when patients take high doses of Nikoramyl 5mg. Very rarely, symptoms of angioedema and liver dysfunction appear. However, if the drug is used in high doses, patients may experience symptoms of a decrease in blood pressure and an increase in heart rate. If aphthous or anal ulcer persists, the patient should discontinue treatment with Nikoramyl 5mg. For headaches, patients should consider gradually increasing the dose to reduce pain symptoms. Meanwhile, the symptoms of tachycardia and hypotension can be overcome by reducing the dose of the drug.
5. Things to keep in mind when using Nikoramyl 5mg
5.1 What precautions should be taken while using Nikoramyl 5mg? When treated with Nikoramyl 5mg, patients need to be cautious of the following:
Use caution in patients with atrioventricular conduction disturbances, myocardial infarction, severe liver disease, cerebral hemorrhage, hypotension. pressure or recent traumatic brain injury. Patients with valvular heart disease, hemodynamic abnormalities or taking other nitrate derivatives should consult their doctor before taking Nikoramyl 5mg. Nikoramyl 5mg should be used with caution in patients undergoing cardiopulmonary surgery due to the potential risk of severe peripheral vasodilatation. Nikoramyl 5mg should be used with caution in patients with hypovolemia, acute pulmonary edema, low systolic blood pressure, low filling pressure, or left ventricular failure. Pregnant women or nursing mothers should only take Nikoramyl 5mg when absolutely necessary and must follow the doctor's prescription. Nikoramyl 5mg has a risk of causing low blood pressure leading to symptoms such as dizziness or fatigue. Therefore, patients who often drive or operate machinery should be cautious when using the drug. 5.2 Interactions of Nikoramyl 5mg with other drugs Nikoramyl 5mg may have an interaction reaction when used at the same time as the following drugs:
5-Phosphodiesterase inhibitors, including Vardenafil, Tadalfil, Sildenafil. Guanylate cyclase stimulators, eg Riociguat. Medicines to treat high blood pressure or to lower blood pressure such as vasodilators, tricyclic antidepressants, or alcohol. Corticosteroids can cause gastrointestinal perforation when combined with Nikoramyl 5mg. Dapoxetine can lower orthostatic blood pressure when used with Nikoramyl 5mg. NSAIDs when used in combination with Nikoramyl may increase the risk of some serious complications such as ulceration, perforation or gastrointestinal bleeding. Drugs to increase blood potassium.
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